In recent years,there has been a growing global demand for carbon neutrality and energy efficiency,which are expected to become long-term trends.In the field of architecture,an effective approach to achieve this is to...In recent years,there has been a growing global demand for carbon neutrality and energy efficiency,which are expected to become long-term trends.In the field of architecture,an effective approach to achieve this is to reduce heat loss in buildings.Vacuum insulation panels(VIPs),a type of high-performance insulation material,have been increasingly utilised in the construction industry and have played an increa-singly important role as their performance and manufacturing processes continue to improve.This paper provides a review of the factors affecting the thermal conductivity of VIPs and presents a detailed overview of the research progress on core materials,barrier films,and getters.The current research status of VIPs is summarised,including their thermal conductivity,service life,and thermal bridging effects,as well as their applications in the field of architecture.This review aims to provide a comprehensive understanding for relevant practitioners on the factors influencing the thermal conductivity of VIPs,and based on which,measures can be taken to produce VIPs with lower thermal conductivity and longer service life.展开更多
This article examines the influence of annealing temperature on fracture toughness and forming limit curves of dissimilar aluminum/silver sheets.In the cold roll bonding process,after brushing and acid washing,the pre...This article examines the influence of annealing temperature on fracture toughness and forming limit curves of dissimilar aluminum/silver sheets.In the cold roll bonding process,after brushing and acid washing,the prepared surfaces are placed on top of each other and by rolling with reduction more than 50%,the bonding between layers is established.In this research,the roll bonding process was done at room temperature,without the use of lubricants and with a 70%thickness reduction.Then,the final thickness of the Ag/Al bilayer sheet reached 350μm by several stages of cold rolling.Before cold rolling,it should be noted that to decrease the hardness created due to plastic deformation,the roll-bonded samples were subjected to annealing heat treatment at 400℃for 90 min.Thus,the final samples were annealed at 200,300 and 400℃for 90 min and cooled in a furnace to examine the annealing temperature effects.The uniaxial tensile and microhardness tests measured mechanical properties.Also,to investigate the fracture mechanism,the fractography of the cross-section was examined by scanning electron microscope(SEM).To evaluate the formability of Ag/Al bilayer sheets,forming limit curves were obtained experimentally through the Nakazima test.The resistance of composites to failure due to cracking was also investigated by fracture toughness.The results showed that annealing increases the elongation and formability of the Ag/Al bilayer sheet while reduces the ultimate tensile strength and fracture toughness.However,the changing trend is not the same at different temperatures,and according to the results,the most significant effect is obtained at 300℃and aluminum layers.It was also determined that by increasing annealing temperature,the fracture mechanism from shear ductile with small and shallow dimples becomes ductile with deep cavities.展开更多
Thrombospondin 4(THBS4;TSP4),a crucial component of the extracellular matrix(ECM),serves as an important regulator of tissue homeostasis and various pathophysiological processes.As a member of the evolutionarily conse...Thrombospondin 4(THBS4;TSP4),a crucial component of the extracellular matrix(ECM),serves as an important regulator of tissue homeostasis and various pathophysiological processes.As a member of the evolutionarily conserved thrombospondin family,THBS4 is a multidomain adhesive glycoprotein characterized by six distinct structural domains that mediate its diverse biological functions.Through dynamic interactions with various ECM components,THBS4 plays pivotal roles in cell adhesion,proliferation,inflammation regulation,and tissue remodeling,establishing it as a key modulator of microenvironmental organization.The transcription and translation of THBS4 gene,as well as the activity of the THBS4 protein,are tightly regulated by multiple signaling pathways and extracellular cues.Positive regulators of THBS4 include transforming growth factorβ(TGF-β),interferonγ(IFNγ),granulocyte-macrophage colony-stimulating factor(GM-CSF),bone morphogenetic proteins(BMP12/13),and other regulatory factors(such as B4GALNT1,ITGA2/ITGB1,PDGFRβ,etc.),which upregulate THBS4 at the mRNA and/or protein level.Conversely,oxidized low-density lipoprotein(OXLDL)acts as a potent negative regulator of THBS4.This intricate regulatory network ensures precise spatial and temporal control of THBS4 expression in response to diverse physiological and pathological stimuli.Functionally,THBS4 acts as a critical signaling hub,influencing multiple downstream pathways essential for cellular behavior and tissue homeostasis.The best-characterized pathways include:(1)the PI3K/AKT/mTOR axis,which THBS4 modulates through both direct and indirect interactions with integrins and growth factor receptors;(2)Wnt/β-catenin signaling,where THBS4 functions as either an activator or inhibitor depending on the cellular context;(3)the suppression of DBET/TRIM69,contributing to its diverse regulatory roles.These signaling connections position THBS4 as a master regulator of cellular responses to microenvironmental changes.Substantial evidence links aberrant THBS4 expression to a range of pathological conditions,including neoplastic diseases,cardiovascular disorders,fibrotic conditions,neurodegenerative diseases,musculoskeletal disorders,and atopic dermatitis.In cancer biology,THBS4 exhibits context-dependent roles,functioning either as a tumor suppressor or promoter depending on the tumor type and microenvironment.In the cardiovascular system,THBS4 contributes to both adaptive remodeling and maladaptive fibrotic responses.Its involvement in fibrotic diseases arises from its ability to regulate ECM deposition and turnover.The diagnostic and therapeutic potential of THBS4 is particularly promising in oncology and cardiovascular medicine.As a biomarker,THBS4 expression patterns correlate significantly with disease progression and patient outcomes.Therapeutically,targeting THBS4-mediated pathways offers novel opportunities for precision medicine approaches,including anti-fibrotic therapies,modulation of the tumor microenvironment,and enhancement of tissue repair.This comprehensive review systematically explores three key aspects of THBS4 research:(1)the fundamental biological functions of THBS4 in ECM organization;(2)its mechanistic involvement in various disease pathologies;(3)its emerging potential as both a diagnostic biomarker and therapeutic target.By integrating recent insights from molecular studies,animal models,and clinical investigations,this review provides a framework for understanding the multifaceted roles of THBS4 in health and disease.The synthesis of current knowledge highlights critical research gaps and future directions for exploring THBS4-targeted interventions across multiple disease contexts.Given its unique position at the intersection of ECM biology and cellular signaling,THBS4 represents a promising frontier for the development of novel diagnostic tools and therapeutic strategies in precision medicine.展开更多
In recent years,perovskite solar cells(PSCs)have garnered significant attention as a potential mainstream technology in the future photovol-taic(PV)market.This is primarily attributed to their salient advantages inclu...In recent years,perovskite solar cells(PSCs)have garnered significant attention as a potential mainstream technology in the future photovol-taic(PV)market.This is primarily attributed to their salient advantages including high efficiency,low cost,and ease of preparation.Nota-bly,the power conversion efficiency(PCE)of PSCs has experienced a remarkable increase from 3.8%in 2009 to over 26%at present.Conse-quently,the adoption of roll-to-roll(R2R)technology for PSCs is considered a crucial step towards their successful commercialization.This arti-de reviews the diverse substrates,scalable deposition techniques(such as solution-based knife-coating and spraying technology),and optimiza.tion procedures employed in recent years to enhance device performance within the R2R process.Additionally,novel perspectives are presented to enrich the existing knowledge in this field.展开更多
The deformation behavior of hot-rolled AZ31 magnesium(Mg)alloy sheet was analyzed when subjected to uniaxial tension along its normal direction at temperatures ranging from 100 to 400℃and strain rates ranging from 0....The deformation behavior of hot-rolled AZ31 magnesium(Mg)alloy sheet was analyzed when subjected to uniaxial tension along its normal direction at temperatures ranging from 100 to 400℃and strain rates ranging from 0.5 to 100 mm/min.Based on the stress−strain curves and the dynamic material model,the hot processing map was established,which demonstrates that the power dissipation factor(η)is the most sensitive to strain rate at 400℃via absorption of dislocations.At 400℃,sample at 0.5 mm/min possessesηof 0.89 because of its lower kernel average misorientation(KAM)value of 0.51,while sample at 100 mm/min possessesηof 0.46 with a higher KAM value of 1.147.In addition,the flow stress presents a slight decrease of 25.94 MPa at 10 mm/min compared to that at 100 mm/min and 100℃.The reasons are twofold:a special~34°texture component during 100℃-100 mm/min favoring the activation of basal slip,and dynamic recrystallization(DRX)also providing softening effect to some extent by absorbing dislocations.Difference in activation of basal slip among twin laminas during 100℃-100 mm/min results in deformation inhomogeneity within the grains,which generates stress that helps matrix grains tilt to a direction favorable to basal slip,forming the special~34°texture component.展开更多
Affected by the geological characteristics of coal bearing strata in western mining areas of China,the double soft composite roof has low strength and poor integrity,which is prone to induce disasters such as large de...Affected by the geological characteristics of coal bearing strata in western mining areas of China,the double soft composite roof has low strength and poor integrity,which is prone to induce disasters such as large deformation and roof collapse.Four-point bending tests were conducted on anchored double-layer rock beams with different pre tightening force and upper/lower rock strength ratios(Ⅰ/Ⅱ)based on the digital speckle correlation method(DSCM).The research results indicate that the instability process of anchored roof can be divided into stages of elastic deformation,crack propagation,alternating fracture,and failure collapse.The proportion of crack propagation and alternating fracture processes increased with the increase of pre-tightening force and Ⅰ/Ⅱ.The pre-tightening force can suppress the sliding of the upper/lower rock interface,and delay the initiation and propagation of cracks.As Ⅰ/Ⅱ increases,the failure mode changes from tensile failure steel strip to shear failure anchor rod.Steel strip can improve the continued bearing effect of anchored roof during crack propagation and alternating fracture processes.展开更多
The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying t...The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement.展开更多
In order to accommodate higher speeds,heavier axle weights,and vibration damping criteria,a new floating slab structure was proposed.The new type of floating slab track structure was composed of three prefabricated fl...In order to accommodate higher speeds,heavier axle weights,and vibration damping criteria,a new floating slab structure was proposed.The new type of floating slab track structure was composed of three prefabricated floating slabs longitudinally interconnected with magnesium ammonium phosphate concrete(MPC).This study investigated the dynamic performance of the structure.We constructd a full-scale indoor experimental model to scrutinize the disparities in the impact performance between a longitudinally connected floating slab track and its longitudinally disconnected counterpart.Additionally,a long-term fatigue experiment was conducted to assess the impact performance of longitudinally connected floating slab tracks under fatigue loading.The findings are described in the following.1)The new structure effectively suppresses ground vibrations,exhibiting a well-balanced energy distribution profile.However,the imposition of fatigue loading leads to a reduction in the damping performance of the steel spring damping system,thereby reducing its capacity to attenuate structural vibrations and leading to an increase in ground vibration energy;2)After 107 loading cycles,the attenuation rate of the vibration acceleration for the MPC increases by 171.9%.Conversely,at the corresponding disconnected location,the attenuation rate of ground vibration acceleration decreases by 65.6%.In conclusion,longitudinally connected floating slab tracks exhibit superior vibration reduction performance.While the vibration reduction performance of longitudinally connected floating slab tracks may diminish to some extent during long-term service,these tracks continue to meet specific vibration reduction requirements.展开更多
Installing the splitter plates is a passive aerodynamic solution for eliminating vortex-induced vibration (VIV). However, the influences of splitter plates on the VIV and aerostatic performances are more complicated d...Installing the splitter plates is a passive aerodynamic solution for eliminating vortex-induced vibration (VIV). However, the influences of splitter plates on the VIV and aerostatic performances are more complicated due to aerodynamic interference between highway and railway decks. To study the effects of splitter plates, wind tunnel experiments for measuring VIV and aerostatic forces of twin decks under two opposite flow directions were conducted, while the surrounding flow and wind pressure of static twin decks with and without splitter plates are numerically simulated. The results showed that the incoming flow direction affects the VIV response and aerostatic coefficients. The highway deck has poor vertical and torsional VIV, and the VIV region and amplitude are different under different directions. While the railway deck only has vertical VIV when located upstream. The splitter plates can impede the process of vortex generation, shedding and impinging at the gap between twin deck, and significantly reducing the surface fluctuating pressure coefficient, thus effectively suppressing the VIV of twin decks. While, the splitter plates hurt the upstream deck regarding static wind stability and have little effect on the downstream deck. The splitter plates of appropriate width are recommended to improve VIV performances in twin parallel bridges.展开更多
To address the issue of extreme thermal-induced arching in CRTS II slab tracks due to joint damage,an optimized joint repair model was proposed.First,the formula for calculating the safe temperature rise of the track ...To address the issue of extreme thermal-induced arching in CRTS II slab tracks due to joint damage,an optimized joint repair model was proposed.First,the formula for calculating the safe temperature rise of the track was derived based on the principle of stationary potential energy.Considering interlayer evolution and structural crack propagation,an optimized joint repair model for the track was established and validated.Subsequently,the impact of joint repair on track damage and arch stability under extreme temperatures was studied,and a comprehensive evaluation of the feasibility of joint repair and the evolution of damage after repair was conducted.The results show that after the joint repair,the temperature rise of the initial damage of the track structure can be increased by 11℃.Under the most unfavorable heating load with a superimposed temperature gradient,the maximum stiffness degradation index SDEG in the track structure is reduced by about 81.16%following joint repair.The joint repair process could effectively reduce the deformation of the slab arching under high temperatures,resulting in a reduction of 93.96%in upward arching deformation.After repair,with the damage to interfacing shear strength,the track arch increases by 2.616 mm.展开更多
Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exis...Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exist in albumin levels and inflammatory cell counts,and further research is required to understand how these differences influence GC prognosis.This study aims to investigate the prognostic impact of nutritional and inflammatory indicators on GC patients undergoing radical surgery,as well as the influence of gender on these indicators’prognostic value.Methods:The study included 596 patients with advanced GC hospitalized in the Department of Gastrointestinal Surgery,General Surgery,Xiangya Hospital of Central South University from January 2012 to December 2016.Receiver operating characteristic(ROC)analysis was performed to determine cutoff values for nutritional and inflammatory factors.Univariate analysis was used to identify factors significantly affecting survival in GC patients,while multivariate and Kaplan-Meier analyses determined independent prognostic factors for GC.Results:Multivariate analysis revealed that postsurgical tumor node metastasis(pTNM)stage[stage II:hazard ratio(HR)=3.284,P=0.012;stage III:HR:8.062,P<0.001],low preoperative AGR(HR=1.499,P=0.012),and postoperative PNI(HR=1.503,P=0.008)were risk factors for overall survival in male patients after radical GC surgery.For female patients,pN2-3(HR=3.185,P<0.001),total gastrectomy(HR=2.286,P=0.004),low preoperative PLR(HR=1.702,P=0.027),and postoperative PNI(HR=1.943,P=0.011)were identified as risk factors for overall survival.Conclusion:Postoperative PNI is an independent risk factor for all advanced GC patients.Preoperative PLR is an independent prognostic factor only for female patients,while preoperative AGR is an independent prognostic factor only for male patients.Further research is warranted to investigate the gender-specific differences in GC prognosis.展开更多
The problems associated with vibrations of viaducts and low-frequency structural noise radiation caused by train excitation continue to increase in importance.A new floating-slab track vibration isolator-non-obstructi...The problems associated with vibrations of viaducts and low-frequency structural noise radiation caused by train excitation continue to increase in importance.A new floating-slab track vibration isolator-non-obstructive particle damping-phononic crystal vibration isolator is proposed herein,which uses the particle damping vibration absorption technology and bandgap vibration control theory.The vibration reduction performance of the NOPD-PCVI was analyzed from the perspective of vibration control.The paper explores the structure-borne noise reduction performance of the NOPD-PCVIs installed on different bridge structures under varying service conditions encountered in practical engineering applications.The load transferred to the bridge is obtained from a coupled train-FST-bridge analytical model considering the different structural parameters of bridges.The vibration responses are obtained using the finite element method,while the structural noise radiation is simulated using the frequency-domain boundary element method.Using the particle swarm optimization algorithm,the parameters of the NOPD-PCVI are optimized so that its frequency bandgap matches the dominant bridge structural noise frequency range.The noise reduction performance of the NOPD-PCVIs is compared to the steel-spring isolation under different service conditions.展开更多
This paper explores the deformation mechanism and control technology of roof pre-splitting for gob-side entries in hard roof full-mechanized longwall caving panel(LTCC).The investigation utilizes a comprehensive appro...This paper explores the deformation mechanism and control technology of roof pre-splitting for gob-side entries in hard roof full-mechanized longwall caving panel(LTCC).The investigation utilizes a comprehensive approach that integrates field monitoring,theoretical analysis,and numerical simulation.Theoretical analysis has illuminated the influence of the length of the lateral cantilever beam of the main roof(LCBM)above the roadway on the stability of the gob-side entry behind the panel.Numerical simulations have further revealed that the longer LCBM results in heightened vertical stress within the coal pillar,developed cracks around the roadway,and more pronounced damage to the roadway.Moreover,numerical simulations also demonstrate the potential of roof pre-splitting technology in optimizing the fracture position of the hard roof.This technology significantly reduces the length of the LCBM,thereby alleviating stress concentration in the coal pillars and integrated coal rib while minimizing the destruction of the gob-side entry.Therefore,this manuscript first proposes the use of roof pre-splitting technology to control roadway deformation,and automatically retain the entry within a hard roof LTCC panel.Field implementation has demonstrated that the proposed automatically retained entry by roof pre-splitting technology effectively reduces gob-side entry deformation and achieves automatically retained entry.展开更多
The complex structure of the bottom of a high-speed train is an important source of train aerodynamic drag.Thus,improving the bottom structure is of great significance to reduce the aerodynamic drag of the train.In th...The complex structure of the bottom of a high-speed train is an important source of train aerodynamic drag.Thus,improving the bottom structure is of great significance to reduce the aerodynamic drag of the train.In this study,computational fluid dynamics(CFD)based on three-dimensional steady incompressible Reynolds-average Naiver-Stokes(RANS)equations and Realizable k-εturbulence model were utilized for numerical simulations.Inspired by the concept of streamlined design and the idea of bottom flow field control,this study iteratively designed the bogies in a streamlined shape and combined them with the bottom deflectors to investigate the joint drag reduction mechanism.Three models,i.e.,single-bogie model,simplified train model,and eight-car high-speed train model,were created and their aerodynamic characteristics were analyzed.The results show that the single-bogie model with streamlined design shows a noticeable drag reduction,whose power bogie and trailer bogie experience 13.92%and 7.63%drag reduction,respectively.The range of positive pressure area on the bogie is reduced.The aerodynamic drag can be further reduced to 15.01%by installing both the streamlined bogie and the deflector on the simplified train model.When the streamlined bogies and deflectors are used on the eight-car model together,the total drag reduction rate reaches 2.90%.Therefore,the proposed aerodynamic kit for the high-speed train bottom is capable to improve the flow structure around the bogie regions,reduce the bottom flow velocity,and narrow the scope of the train’s influence on the surrounding environment,achieving the appreciable reduction of aerodynamic drag.This paper can provide a new idea for the drag reduction of high-speed trains.展开更多
In this study, the influence of opening parameters on the ultimate strength of perforated plates subjected to extreme cyclic loading in the presence of material kinematic hardening and isotro pic hardening was analyze...In this study, the influence of opening parameters on the ultimate strength of perforated plates subjected to extreme cyclic loading in the presence of material kinematic hardening and isotro pic hardening was analyzed. It is found that the ultimate strength of the perforated plates decreases rapidly and stabilizes in the first four cycles. Plates with oblong openings have a greater ultimate strength compared to plates with rectangular openings, while the relative strengthening ratio decreases over the duration of the cycle. The location of the openings is also an important parameter that affects the strength of the structure, as the plates with openings close to the edges in the longitudinal direction have higher strengths, while in the transverse direction the strengths are higher when the openings are close to the center. Among the three opening-strengthening methods compared, the Carling stiffener method maintains a better strengthening effect under cyclic loads for many periods.展开更多
The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is us...The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is useful for operating and controlling the temperature,especially in photovoltaic technology and solar panels.Motivated by these applications,the current study is based on the nanoparticle aggregation effect on magnetohydrodynamics(MHD)flow via rotating parallel plates with the chemical reaction.To achieve maximum heat transportation,the Bruggeman model is used to adapt the Maxwell model.Also,melting and thermal radiation effects are considered in the modeling to discuss heat transport.The Runge-Kutta-Fehlberg 4th−5th order method is used to attain numerical solutions.The main focus of this study is to see the thermodynamic behavior considering several aspects of nanoparticle aggregation.The heat transfer rate between the parallel plates is enhanced by improving the thermophoresis,radiation,and Brownian motion parameters.The rise in Schmidt number and chemical reaction rate parameter decreases the concentration distribution.This study will be helpful in enhancing the thermal efficiency of photovoltaic technology in solar plates,water purifying,thermal management of electronic devices,designing effective cooling systems,and other sustainable technologies.展开更多
文摘In recent years,there has been a growing global demand for carbon neutrality and energy efficiency,which are expected to become long-term trends.In the field of architecture,an effective approach to achieve this is to reduce heat loss in buildings.Vacuum insulation panels(VIPs),a type of high-performance insulation material,have been increasingly utilised in the construction industry and have played an increa-singly important role as their performance and manufacturing processes continue to improve.This paper provides a review of the factors affecting the thermal conductivity of VIPs and presents a detailed overview of the research progress on core materials,barrier films,and getters.The current research status of VIPs is summarised,including their thermal conductivity,service life,and thermal bridging effects,as well as their applications in the field of architecture.This review aims to provide a comprehensive understanding for relevant practitioners on the factors influencing the thermal conductivity of VIPs,and based on which,measures can be taken to produce VIPs with lower thermal conductivity and longer service life.
基金Project(4013311)supported by the National Science Foundation of Iran(INSF)。
文摘This article examines the influence of annealing temperature on fracture toughness and forming limit curves of dissimilar aluminum/silver sheets.In the cold roll bonding process,after brushing and acid washing,the prepared surfaces are placed on top of each other and by rolling with reduction more than 50%,the bonding between layers is established.In this research,the roll bonding process was done at room temperature,without the use of lubricants and with a 70%thickness reduction.Then,the final thickness of the Ag/Al bilayer sheet reached 350μm by several stages of cold rolling.Before cold rolling,it should be noted that to decrease the hardness created due to plastic deformation,the roll-bonded samples were subjected to annealing heat treatment at 400℃for 90 min.Thus,the final samples were annealed at 200,300 and 400℃for 90 min and cooled in a furnace to examine the annealing temperature effects.The uniaxial tensile and microhardness tests measured mechanical properties.Also,to investigate the fracture mechanism,the fractography of the cross-section was examined by scanning electron microscope(SEM).To evaluate the formability of Ag/Al bilayer sheets,forming limit curves were obtained experimentally through the Nakazima test.The resistance of composites to failure due to cracking was also investigated by fracture toughness.The results showed that annealing increases the elongation and formability of the Ag/Al bilayer sheet while reduces the ultimate tensile strength and fracture toughness.However,the changing trend is not the same at different temperatures,and according to the results,the most significant effect is obtained at 300℃and aluminum layers.It was also determined that by increasing annealing temperature,the fracture mechanism from shear ductile with small and shallow dimples becomes ductile with deep cavities.
文摘Thrombospondin 4(THBS4;TSP4),a crucial component of the extracellular matrix(ECM),serves as an important regulator of tissue homeostasis and various pathophysiological processes.As a member of the evolutionarily conserved thrombospondin family,THBS4 is a multidomain adhesive glycoprotein characterized by six distinct structural domains that mediate its diverse biological functions.Through dynamic interactions with various ECM components,THBS4 plays pivotal roles in cell adhesion,proliferation,inflammation regulation,and tissue remodeling,establishing it as a key modulator of microenvironmental organization.The transcription and translation of THBS4 gene,as well as the activity of the THBS4 protein,are tightly regulated by multiple signaling pathways and extracellular cues.Positive regulators of THBS4 include transforming growth factorβ(TGF-β),interferonγ(IFNγ),granulocyte-macrophage colony-stimulating factor(GM-CSF),bone morphogenetic proteins(BMP12/13),and other regulatory factors(such as B4GALNT1,ITGA2/ITGB1,PDGFRβ,etc.),which upregulate THBS4 at the mRNA and/or protein level.Conversely,oxidized low-density lipoprotein(OXLDL)acts as a potent negative regulator of THBS4.This intricate regulatory network ensures precise spatial and temporal control of THBS4 expression in response to diverse physiological and pathological stimuli.Functionally,THBS4 acts as a critical signaling hub,influencing multiple downstream pathways essential for cellular behavior and tissue homeostasis.The best-characterized pathways include:(1)the PI3K/AKT/mTOR axis,which THBS4 modulates through both direct and indirect interactions with integrins and growth factor receptors;(2)Wnt/β-catenin signaling,where THBS4 functions as either an activator or inhibitor depending on the cellular context;(3)the suppression of DBET/TRIM69,contributing to its diverse regulatory roles.These signaling connections position THBS4 as a master regulator of cellular responses to microenvironmental changes.Substantial evidence links aberrant THBS4 expression to a range of pathological conditions,including neoplastic diseases,cardiovascular disorders,fibrotic conditions,neurodegenerative diseases,musculoskeletal disorders,and atopic dermatitis.In cancer biology,THBS4 exhibits context-dependent roles,functioning either as a tumor suppressor or promoter depending on the tumor type and microenvironment.In the cardiovascular system,THBS4 contributes to both adaptive remodeling and maladaptive fibrotic responses.Its involvement in fibrotic diseases arises from its ability to regulate ECM deposition and turnover.The diagnostic and therapeutic potential of THBS4 is particularly promising in oncology and cardiovascular medicine.As a biomarker,THBS4 expression patterns correlate significantly with disease progression and patient outcomes.Therapeutically,targeting THBS4-mediated pathways offers novel opportunities for precision medicine approaches,including anti-fibrotic therapies,modulation of the tumor microenvironment,and enhancement of tissue repair.This comprehensive review systematically explores three key aspects of THBS4 research:(1)the fundamental biological functions of THBS4 in ECM organization;(2)its mechanistic involvement in various disease pathologies;(3)its emerging potential as both a diagnostic biomarker and therapeutic target.By integrating recent insights from molecular studies,animal models,and clinical investigations,this review provides a framework for understanding the multifaceted roles of THBS4 in health and disease.The synthesis of current knowledge highlights critical research gaps and future directions for exploring THBS4-targeted interventions across multiple disease contexts.Given its unique position at the intersection of ECM biology and cellular signaling,THBS4 represents a promising frontier for the development of novel diagnostic tools and therapeutic strategies in precision medicine.
文摘In recent years,perovskite solar cells(PSCs)have garnered significant attention as a potential mainstream technology in the future photovol-taic(PV)market.This is primarily attributed to their salient advantages including high efficiency,low cost,and ease of preparation.Nota-bly,the power conversion efficiency(PCE)of PSCs has experienced a remarkable increase from 3.8%in 2009 to over 26%at present.Conse-quently,the adoption of roll-to-roll(R2R)technology for PSCs is considered a crucial step towards their successful commercialization.This arti-de reviews the diverse substrates,scalable deposition techniques(such as solution-based knife-coating and spraying technology),and optimiza.tion procedures employed in recent years to enhance device performance within the R2R process.Additionally,novel perspectives are presented to enrich the existing knowledge in this field.
基金Project(52005362) supported by the National Natural Science Foundation of ChinaProjects(202303021221005,202303021211045) supported by the Natural Science Foundation of Shanxi Province,China+1 种基金Project(202402003) supported by the Patent Commercialization Program of Shanxi Province,ChinaProject supported by the Key Research and Development Plan of Xinzhou City,China。
文摘The deformation behavior of hot-rolled AZ31 magnesium(Mg)alloy sheet was analyzed when subjected to uniaxial tension along its normal direction at temperatures ranging from 100 to 400℃and strain rates ranging from 0.5 to 100 mm/min.Based on the stress−strain curves and the dynamic material model,the hot processing map was established,which demonstrates that the power dissipation factor(η)is the most sensitive to strain rate at 400℃via absorption of dislocations.At 400℃,sample at 0.5 mm/min possessesηof 0.89 because of its lower kernel average misorientation(KAM)value of 0.51,while sample at 100 mm/min possessesηof 0.46 with a higher KAM value of 1.147.In addition,the flow stress presents a slight decrease of 25.94 MPa at 10 mm/min compared to that at 100 mm/min and 100℃.The reasons are twofold:a special~34°texture component during 100℃-100 mm/min favoring the activation of basal slip,and dynamic recrystallization(DRX)also providing softening effect to some extent by absorbing dislocations.Difference in activation of basal slip among twin laminas during 100℃-100 mm/min results in deformation inhomogeneity within the grains,which generates stress that helps matrix grains tilt to a direction favorable to basal slip,forming the special~34°texture component.
基金Project(SDAST2024QT060)supported by the Young Talent of Lifting Engineering for Science and Technology in Shandong,ChinaProjects(52304136,52304149,52204093)supported by the National Natural Science Foundation of China+1 种基金Project(ZR2022ME165)supported by the Shandong Provincial Natural Science Foundation,ChinaProject(2023YD02)supported by the Key Project of Research and Development in Liaocheng,China。
文摘Affected by the geological characteristics of coal bearing strata in western mining areas of China,the double soft composite roof has low strength and poor integrity,which is prone to induce disasters such as large deformation and roof collapse.Four-point bending tests were conducted on anchored double-layer rock beams with different pre tightening force and upper/lower rock strength ratios(Ⅰ/Ⅱ)based on the digital speckle correlation method(DSCM).The research results indicate that the instability process of anchored roof can be divided into stages of elastic deformation,crack propagation,alternating fracture,and failure collapse.The proportion of crack propagation and alternating fracture processes increased with the increase of pre-tightening force and Ⅰ/Ⅱ.The pre-tightening force can suppress the sliding of the upper/lower rock interface,and delay the initiation and propagation of cracks.As Ⅰ/Ⅱ increases,the failure mode changes from tensile failure steel strip to shear failure anchor rod.Steel strip can improve the continued bearing effect of anchored roof during crack propagation and alternating fracture processes.
基金Project(52204164)supported by the National Natural Science Foundation of ChinaProject(2021QNRC001)supported by the Young Elite Scientists Sponsorship Program by CAST,China。
文摘The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement.
基金Project(2022-Major-14)supported by the Science and Technology Research and Development Program Project of China Railway Group Limited。
文摘In order to accommodate higher speeds,heavier axle weights,and vibration damping criteria,a new floating slab structure was proposed.The new type of floating slab track structure was composed of three prefabricated floating slabs longitudinally interconnected with magnesium ammonium phosphate concrete(MPC).This study investigated the dynamic performance of the structure.We constructd a full-scale indoor experimental model to scrutinize the disparities in the impact performance between a longitudinally connected floating slab track and its longitudinally disconnected counterpart.Additionally,a long-term fatigue experiment was conducted to assess the impact performance of longitudinally connected floating slab tracks under fatigue loading.The findings are described in the following.1)The new structure effectively suppresses ground vibrations,exhibiting a well-balanced energy distribution profile.However,the imposition of fatigue loading leads to a reduction in the damping performance of the steel spring damping system,thereby reducing its capacity to attenuate structural vibrations and leading to an increase in ground vibration energy;2)After 107 loading cycles,the attenuation rate of the vibration acceleration for the MPC increases by 171.9%.Conversely,at the corresponding disconnected location,the attenuation rate of ground vibration acceleration decreases by 65.6%.In conclusion,longitudinally connected floating slab tracks exhibit superior vibration reduction performance.While the vibration reduction performance of longitudinally connected floating slab tracks may diminish to some extent during long-term service,these tracks continue to meet specific vibration reduction requirements.
基金Projects(51925808,52078504,51822803) supported by the National Natural Science Foundation of ChinaProject(2022JJ10082) supported by the Natural Science Foundation of Hunan Province,China+1 种基金Project(N2022Z004) supported by the Research on Technology Development Trend and Key Common Problems in Railway,ChinaProject(Xplorer Prize 2021) supported by the Tencent Foundation,China。
文摘Installing the splitter plates is a passive aerodynamic solution for eliminating vortex-induced vibration (VIV). However, the influences of splitter plates on the VIV and aerostatic performances are more complicated due to aerodynamic interference between highway and railway decks. To study the effects of splitter plates, wind tunnel experiments for measuring VIV and aerostatic forces of twin decks under two opposite flow directions were conducted, while the surrounding flow and wind pressure of static twin decks with and without splitter plates are numerically simulated. The results showed that the incoming flow direction affects the VIV response and aerostatic coefficients. The highway deck has poor vertical and torsional VIV, and the VIV region and amplitude are different under different directions. While the railway deck only has vertical VIV when located upstream. The splitter plates can impede the process of vortex generation, shedding and impinging at the gap between twin deck, and significantly reducing the surface fluctuating pressure coefficient, thus effectively suppressing the VIV of twin decks. While, the splitter plates hurt the upstream deck regarding static wind stability and have little effect on the downstream deck. The splitter plates of appropriate width are recommended to improve VIV performances in twin parallel bridges.
基金Project(K2022G038)supported by the Science Technology Research and Development Program of China State Railway Group Co.,LtdProject(52178405)supported by the National Natural Science Foundation of China。
文摘To address the issue of extreme thermal-induced arching in CRTS II slab tracks due to joint damage,an optimized joint repair model was proposed.First,the formula for calculating the safe temperature rise of the track was derived based on the principle of stationary potential energy.Considering interlayer evolution and structural crack propagation,an optimized joint repair model for the track was established and validated.Subsequently,the impact of joint repair on track damage and arch stability under extreme temperatures was studied,and a comprehensive evaluation of the feasibility of joint repair and the evolution of damage after repair was conducted.The results show that after the joint repair,the temperature rise of the initial damage of the track structure can be increased by 11℃.Under the most unfavorable heating load with a superimposed temperature gradient,the maximum stiffness degradation index SDEG in the track structure is reduced by about 81.16%following joint repair.The joint repair process could effectively reduce the deformation of the slab arching under high temperatures,resulting in a reduction of 93.96%in upward arching deformation.After repair,with the damage to interfacing shear strength,the track arch increases by 2.616 mm.
基金supported by the National Natural Science Foundation of China(8197103463).
文摘Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exist in albumin levels and inflammatory cell counts,and further research is required to understand how these differences influence GC prognosis.This study aims to investigate the prognostic impact of nutritional and inflammatory indicators on GC patients undergoing radical surgery,as well as the influence of gender on these indicators’prognostic value.Methods:The study included 596 patients with advanced GC hospitalized in the Department of Gastrointestinal Surgery,General Surgery,Xiangya Hospital of Central South University from January 2012 to December 2016.Receiver operating characteristic(ROC)analysis was performed to determine cutoff values for nutritional and inflammatory factors.Univariate analysis was used to identify factors significantly affecting survival in GC patients,while multivariate and Kaplan-Meier analyses determined independent prognostic factors for GC.Results:Multivariate analysis revealed that postsurgical tumor node metastasis(pTNM)stage[stage II:hazard ratio(HR)=3.284,P=0.012;stage III:HR:8.062,P<0.001],low preoperative AGR(HR=1.499,P=0.012),and postoperative PNI(HR=1.503,P=0.008)were risk factors for overall survival in male patients after radical GC surgery.For female patients,pN2-3(HR=3.185,P<0.001),total gastrectomy(HR=2.286,P=0.004),low preoperative PLR(HR=1.702,P=0.027),and postoperative PNI(HR=1.943,P=0.011)were identified as risk factors for overall survival.Conclusion:Postoperative PNI is an independent risk factor for all advanced GC patients.Preoperative PLR is an independent prognostic factor only for female patients,while preoperative AGR is an independent prognostic factor only for male patients.Further research is warranted to investigate the gender-specific differences in GC prognosis.
基金Project(51978585)supported by the National Natural Science Foundation,ChinaProject(2022YFB2603404)supported by the National Key Research and Development Program,China+1 种基金Project(U1734207)supported by the High-speed Rail Joint Fund Key Projects of Basic Research,ChinaProject(2023NSFSC1975)supported by the Sichuan Nature and Science Foundation Innovation Research Group Project,China。
文摘The problems associated with vibrations of viaducts and low-frequency structural noise radiation caused by train excitation continue to increase in importance.A new floating-slab track vibration isolator-non-obstructive particle damping-phononic crystal vibration isolator is proposed herein,which uses the particle damping vibration absorption technology and bandgap vibration control theory.The vibration reduction performance of the NOPD-PCVI was analyzed from the perspective of vibration control.The paper explores the structure-borne noise reduction performance of the NOPD-PCVIs installed on different bridge structures under varying service conditions encountered in practical engineering applications.The load transferred to the bridge is obtained from a coupled train-FST-bridge analytical model considering the different structural parameters of bridges.The vibration responses are obtained using the finite element method,while the structural noise radiation is simulated using the frequency-domain boundary element method.Using the particle swarm optimization algorithm,the parameters of the NOPD-PCVI are optimized so that its frequency bandgap matches the dominant bridge structural noise frequency range.The noise reduction performance of the NOPD-PCVIs is compared to the steel-spring isolation under different service conditions.
基金Project(52104139)supported by the National Natural Science Foundation of China Youth Science FoundationProject(SKLGDUEK2132)supported by the State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology/China University of Mining and Technology-BeijingProjects([2020]2Y030,[2020]2Y019,[2020j3007,[2020]3008,and[2022j0il]supported by the Guizhou Province Science and Technology Planning,China Project(2022B01051)supported by the Key Research and Development Special Tasks of Xinjiang,China。
文摘This paper explores the deformation mechanism and control technology of roof pre-splitting for gob-side entries in hard roof full-mechanized longwall caving panel(LTCC).The investigation utilizes a comprehensive approach that integrates field monitoring,theoretical analysis,and numerical simulation.Theoretical analysis has illuminated the influence of the length of the lateral cantilever beam of the main roof(LCBM)above the roadway on the stability of the gob-side entry behind the panel.Numerical simulations have further revealed that the longer LCBM results in heightened vertical stress within the coal pillar,developed cracks around the roadway,and more pronounced damage to the roadway.Moreover,numerical simulations also demonstrate the potential of roof pre-splitting technology in optimizing the fracture position of the hard roof.This technology significantly reduces the length of the LCBM,thereby alleviating stress concentration in the coal pillars and integrated coal rib while minimizing the destruction of the gob-side entry.Therefore,this manuscript first proposes the use of roof pre-splitting technology to control roadway deformation,and automatically retain the entry within a hard roof LTCC panel.Field implementation has demonstrated that the proposed automatically retained entry by roof pre-splitting technology effectively reduces gob-side entry deformation and achieves automatically retained entry.
基金Project(2020YFA0710901)supported by the National Key Research and Development Program of ChinaProject(2023JJ30643)supported by the Natural Science Foundation of Hunan Province,China+1 种基金Project(12372204)supported by the National Natural Science Foundation of ChinaProject(2022ZZTS0725)supported by the Self-exploration and Innovation Project for Postgraduates of Central South University,China。
文摘The complex structure of the bottom of a high-speed train is an important source of train aerodynamic drag.Thus,improving the bottom structure is of great significance to reduce the aerodynamic drag of the train.In this study,computational fluid dynamics(CFD)based on three-dimensional steady incompressible Reynolds-average Naiver-Stokes(RANS)equations and Realizable k-εturbulence model were utilized for numerical simulations.Inspired by the concept of streamlined design and the idea of bottom flow field control,this study iteratively designed the bogies in a streamlined shape and combined them with the bottom deflectors to investigate the joint drag reduction mechanism.Three models,i.e.,single-bogie model,simplified train model,and eight-car high-speed train model,were created and their aerodynamic characteristics were analyzed.The results show that the single-bogie model with streamlined design shows a noticeable drag reduction,whose power bogie and trailer bogie experience 13.92%and 7.63%drag reduction,respectively.The range of positive pressure area on the bogie is reduced.The aerodynamic drag can be further reduced to 15.01%by installing both the streamlined bogie and the deflector on the simplified train model.When the streamlined bogies and deflectors are used on the eight-car model together,the total drag reduction rate reaches 2.90%.Therefore,the proposed aerodynamic kit for the high-speed train bottom is capable to improve the flow structure around the bogie regions,reduce the bottom flow velocity,and narrow the scope of the train’s influence on the surrounding environment,achieving the appreciable reduction of aerodynamic drag.This paper can provide a new idea for the drag reduction of high-speed trains.
文摘In this study, the influence of opening parameters on the ultimate strength of perforated plates subjected to extreme cyclic loading in the presence of material kinematic hardening and isotro pic hardening was analyzed. It is found that the ultimate strength of the perforated plates decreases rapidly and stabilizes in the first four cycles. Plates with oblong openings have a greater ultimate strength compared to plates with rectangular openings, while the relative strengthening ratio decreases over the duration of the cycle. The location of the openings is also an important parameter that affects the strength of the structure, as the plates with openings close to the edges in the longitudinal direction have higher strengths, while in the transverse direction the strengths are higher when the openings are close to the center. Among the three opening-strengthening methods compared, the Carling stiffener method maintains a better strengthening effect under cyclic loads for many periods.
基金Large research project(RGP2/159/45)supported by the Deanship of Research and Graduate Studies at King Khalid University,Saudi Arabia。
文摘The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is useful for operating and controlling the temperature,especially in photovoltaic technology and solar panels.Motivated by these applications,the current study is based on the nanoparticle aggregation effect on magnetohydrodynamics(MHD)flow via rotating parallel plates with the chemical reaction.To achieve maximum heat transportation,the Bruggeman model is used to adapt the Maxwell model.Also,melting and thermal radiation effects are considered in the modeling to discuss heat transport.The Runge-Kutta-Fehlberg 4th−5th order method is used to attain numerical solutions.The main focus of this study is to see the thermodynamic behavior considering several aspects of nanoparticle aggregation.The heat transfer rate between the parallel plates is enhanced by improving the thermophoresis,radiation,and Brownian motion parameters.The rise in Schmidt number and chemical reaction rate parameter decreases the concentration distribution.This study will be helpful in enhancing the thermal efficiency of photovoltaic technology in solar plates,water purifying,thermal management of electronic devices,designing effective cooling systems,and other sustainable technologies.
