A nanomicelle(denoted as TPGS/Ppa)was fabricated via the coassembly of the amphiphilic D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS)and the hydrophobic photosensitizer pyropheophorbide a(Ppa)for photodynami...A nanomicelle(denoted as TPGS/Ppa)was fabricated via the coassembly of the amphiphilic D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS)and the hydrophobic photosensitizer pyropheophorbide a(Ppa)for photodynamic therapy(PDT).The obtained nanomicelle possessed a spherical structure with a diameter of(18.0±2.2)nm and a zeta potential of approximately -18 mV.Besides,the nanomicelle exhibited excellent photostability,biocompatibility,and phototoxicity,and could effectively reach the tumor region via the enhanced permeability and retention effect.Additionally,it could be found that the TPGS/Ppa nanomicelle exhibited higher phototoxicity against 4T1 murine mammary cancer cells than free Ppa.In the 4T1 tumor-bearing mouse model,the nanomicelle showed an excellent antitumor therapeutic effect.This study develops a new type of photodynamic nanomicelle TPGS/Ppa,which can increase the accumulation of drugs and prolong their tumor retention time,providing a feasible strategy for realizing the delivery of small-molecule hydrophobic drugs and tumor PDT.展开更多
In order to improve the quality of loading and make the ammuni- tion safe in use,a new loading technique of ordered solidification has been studied.The study shows that the adoption of this new technique makes the cha...In order to improve the quality of loading and make the ammuni- tion safe in use,a new loading technique of ordered solidification has been studied.The study shows that the adoption of this new technique makes the charge more compact and brings about a satisfactory supplement of liquid ex- plosives,thus increasing the charge density,which is most advantageous to the crimination of pores,cavities,gaps at the bottom and in loose struc- tures.The physical mechanical properties of the charge are hence greatly im- proved,and the sensitivity of the charge to environmental stimulations is much lowered.展开更多
Aim To study fuel dispersion in fuel air explosive(FAE) and computational ways of fuel dispersion velocity in the near area. Methods\ The dispersion process of fuel in FAE was analyzed by the use of results measured ...Aim To study fuel dispersion in fuel air explosive(FAE) and computational ways of fuel dispersion velocity in the near area. Methods\ The dispersion process of fuel in FAE was analyzed by the use of results measured with KODAK EKTAPRO EM Motion Analyzer and setting up mechanical models. Results\ Computational methods for fuel dispersion velocity in the acceleration stage is given and taken as a base for the study of fuel dispersion in the intermediate and the far area. Conclusion\ When the fuel flow velocity is higher than that of the explosion gas in the center cavity, the fuel divides with the explosion gas and its velocity of flow reaches a maximum. The acceleration stage ends at that time. The fuel dispersion velocity at this time is the initial conditions for numeral analyses of dispersion process in the intermediate and far areas.展开更多
Shaped charge jet formation process is studied under the conditions of different background lights by means of high speed frame photography. In order to shoot true jet appearance, the glass tube in which jet moves is...Shaped charge jet formation process is studied under the conditions of different background lights by means of high speed frame photography. In order to shoot true jet appearance, the glass tube in which jet moves is vacuumized. The experiment results show that observing jet appearance with the double reflecting mirrors system is feasible as long as the vacuum of the glass tube can meet the requirement of experiment.展开更多
Betulin, which is a medicinal pentacyclic triterpene, is abundant in the bark of white birch (Betula platyphlly). The bark of birch was collected at Tayuan Forest Farm of Jiagedaqi, Heilongjiang Province in September ...Betulin, which is a medicinal pentacyclic triterpene, is abundant in the bark of white birch (Betula platyphlly). The bark of birch was collected at Tayuan Forest Farm of Jiagedaqi, Heilongjiang Province in September 2000. Supercritical fluid extraction (SFE) that is a new separation technology has been used for the processing pharmaceutical and natural products. In this paper, the extraction of betulin from the bark of birch by supercritical CO2 extraction was studied. The authors investigated and analyzed a few parameters such as modifier dosage, extraction pressure and extraction temperature. The optimal extrac-tion conditions showed that the modifier dosage used for per gram bark powder was 1.5 mL, the extraction pressure was at 20 Mpa, and the extraction temperature was at 55 C. The velocity of flow of liquid CO2 was at 10 kg/h. The pressure and tem-perature in separation vessel were at 5.5 Mpa and 50 C, respectively.展开更多
This paper analyses the geometrical analogue rules of explosively formed projectile (EFP) penetrating armours with the help of similarity theory, and establishes EFP penetrating armour simulation law. Based on the si...This paper analyses the geometrical analogue rules of explosively formed projectile (EFP) penetrating armours with the help of similarity theory, and establishes EFP penetrating armour simulation law. Based on the simulation law established here, prototype experiments and model experiments with the simulation ratio of 1.33 are designed, and the penetrating armour experiments with 45 # carbon steel plates are separately conducted. By means of data processing of experimental results, it is concluded that EFP penetrating armour simulation law established is tenable.展开更多
文摘A nanomicelle(denoted as TPGS/Ppa)was fabricated via the coassembly of the amphiphilic D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS)and the hydrophobic photosensitizer pyropheophorbide a(Ppa)for photodynamic therapy(PDT).The obtained nanomicelle possessed a spherical structure with a diameter of(18.0±2.2)nm and a zeta potential of approximately -18 mV.Besides,the nanomicelle exhibited excellent photostability,biocompatibility,and phototoxicity,and could effectively reach the tumor region via the enhanced permeability and retention effect.Additionally,it could be found that the TPGS/Ppa nanomicelle exhibited higher phototoxicity against 4T1 murine mammary cancer cells than free Ppa.In the 4T1 tumor-bearing mouse model,the nanomicelle showed an excellent antitumor therapeutic effect.This study develops a new type of photodynamic nanomicelle TPGS/Ppa,which can increase the accumulation of drugs and prolong their tumor retention time,providing a feasible strategy for realizing the delivery of small-molecule hydrophobic drugs and tumor PDT.
文摘In order to improve the quality of loading and make the ammuni- tion safe in use,a new loading technique of ordered solidification has been studied.The study shows that the adoption of this new technique makes the charge more compact and brings about a satisfactory supplement of liquid ex- plosives,thus increasing the charge density,which is most advantageous to the crimination of pores,cavities,gaps at the bottom and in loose struc- tures.The physical mechanical properties of the charge are hence greatly im- proved,and the sensitivity of the charge to environmental stimulations is much lowered.
文摘Aim To study fuel dispersion in fuel air explosive(FAE) and computational ways of fuel dispersion velocity in the near area. Methods\ The dispersion process of fuel in FAE was analyzed by the use of results measured with KODAK EKTAPRO EM Motion Analyzer and setting up mechanical models. Results\ Computational methods for fuel dispersion velocity in the acceleration stage is given and taken as a base for the study of fuel dispersion in the intermediate and the far area. Conclusion\ When the fuel flow velocity is higher than that of the explosion gas in the center cavity, the fuel divides with the explosion gas and its velocity of flow reaches a maximum. The acceleration stage ends at that time. The fuel dispersion velocity at this time is the initial conditions for numeral analyses of dispersion process in the intermediate and far areas.
文摘Shaped charge jet formation process is studied under the conditions of different background lights by means of high speed frame photography. In order to shoot true jet appearance, the glass tube in which jet moves is vacuumized. The experiment results show that observing jet appearance with the double reflecting mirrors system is feasible as long as the vacuum of the glass tube can meet the requirement of experiment.
文摘Betulin, which is a medicinal pentacyclic triterpene, is abundant in the bark of white birch (Betula platyphlly). The bark of birch was collected at Tayuan Forest Farm of Jiagedaqi, Heilongjiang Province in September 2000. Supercritical fluid extraction (SFE) that is a new separation technology has been used for the processing pharmaceutical and natural products. In this paper, the extraction of betulin from the bark of birch by supercritical CO2 extraction was studied. The authors investigated and analyzed a few parameters such as modifier dosage, extraction pressure and extraction temperature. The optimal extrac-tion conditions showed that the modifier dosage used for per gram bark powder was 1.5 mL, the extraction pressure was at 20 Mpa, and the extraction temperature was at 55 C. The velocity of flow of liquid CO2 was at 10 kg/h. The pressure and tem-perature in separation vessel were at 5.5 Mpa and 50 C, respectively.
文摘This paper analyses the geometrical analogue rules of explosively formed projectile (EFP) penetrating armours with the help of similarity theory, and establishes EFP penetrating armour simulation law. Based on the simulation law established here, prototype experiments and model experiments with the simulation ratio of 1.33 are designed, and the penetrating armour experiments with 45 # carbon steel plates are separately conducted. By means of data processing of experimental results, it is concluded that EFP penetrating armour simulation law established is tenable.
