目的:鼻咽癌发病位置隐匿导致早期诊断率低,且具有明显的地域聚集性,是中国一个重要的公共卫生问题。本研究旨在通过2021年全球疾病负担(the Global Burden of Diseases,GBD)数据库分析中国鼻咽癌的疾病负担,为鼻咽癌的精准防控提供流...目的:鼻咽癌发病位置隐匿导致早期诊断率低,且具有明显的地域聚集性,是中国一个重要的公共卫生问题。本研究旨在通过2021年全球疾病负担(the Global Burden of Diseases,GBD)数据库分析中国鼻咽癌的疾病负担,为鼻咽癌的精准防控提供流行病学依据。方法:选取年龄标化发病率、病死率、伤残调整寿命年(disability adjusted life year,DALY)率作为疾病负担的评价指标,按照不同年龄、性别、社会人口学指数及其相关危险因素进行分层分析,同时应用差分自回归移动平均(autoregressive integrated moving average,ARIMA)模型和贝叶斯年龄-时期-队列分析模型(Bayesian age-period-cohort,BAPC)将年龄标化发病率预测至2050年。结果:2021年中国鼻咽癌年龄标化发病率、病死率、DALY率分别为3.4/10万、1.5/10万、48.7/10万,均高于同期全球水平。在所有年龄段,中国男性年龄标化发病率、病死率、DALY率均高于女性。中国鼻咽癌的疾病负担从1990至2021年随着社会人口学指数(socio-demographic index,SDI)的增高逐渐降低。中国归因于饮酒、吸烟、职业甲醛暴露的鼻咽癌疾病负担占比均高于全球水平,且在男性中尤为显著。模型预测中国及全球男性、女性、全人群的年龄标化发病率均提示从2022至2050年呈上升趋势。结论:既往30年中国鼻咽癌的疾病负担随着SDI的升高逐渐降低,但仍高于同期全球水平。同时,中国鼻咽癌的年龄标化发病率在未来30年呈上升趋势。中国仍需进一步增加医疗资源的投入以应对鼻咽癌的防控与诊疗,尤其针对高风险男性群体。展开更多
Experimental study is performed on the probabilistic models for the long fatigue crack growth rates (da/dN) of LZ50 axle steel. An equation for crack growth rate was derived to consider the trend of stress intensity f...Experimental study is performed on the probabilistic models for the long fatigue crack growth rates (da/dN) of LZ50 axle steel. An equation for crack growth rate was derived to consider the trend of stress intensity factor range going down to the threshold and the average stress effect. The probabilistic models were presented on the equation. They consist of the probabilistic da/dN-ΔK relations, the confidence-based da/dN-ΔK relations, and the probabilistic- and confidence-based da/dN-ΔK relations. Efforts were made respectively to characterize the effects of probabilistic assessments due to the scattering regularity of test data, the number of sampling, and both of them. These relations can provide wide selections for practice. Analysis on the test data of LZ50 steel indicates that the present models are available and feasible.展开更多
为了研究模块化多电平换流器(modular multilevel converter,MMC)在嵌入储能系统(battery energy storage system,BESS)后内部动态特性的变化规律,对MMC-BESS的运行特性进行了详细分析,并提出了一种桥臂级平均值模型(arm average model,...为了研究模块化多电平换流器(modular multilevel converter,MMC)在嵌入储能系统(battery energy storage system,BESS)后内部动态特性的变化规律,对MMC-BESS的运行特性进行了详细分析,并提出了一种桥臂级平均值模型(arm average model,AAM)进行验证。首先,在假设桥臂中各储能子模块状态一致的前提下,将离散环节连续化,并根据电路特性方程构建了MMC-BESS的AAM电路模型。然后,根据交流端、直流端以及储能端之间的功率关系对MMC-BESS的运行模式进行划分,建立了桥臂电流与电池功率之间的关系,并对电池功率不均衡状态下的桥臂电流进行了分析。最后,利用Matlab/Simulink分别搭建了MMC-BESS的开关模型和AAM模型,并基于AAM验证了多种工况下的桥臂电流响应。仿真结果表明,AAM在显著提高仿真效率的同时可保证较高的准确性,电池功率的大小与均衡状况对桥臂电流的成分有较大影响。展开更多
文摘目的:鼻咽癌发病位置隐匿导致早期诊断率低,且具有明显的地域聚集性,是中国一个重要的公共卫生问题。本研究旨在通过2021年全球疾病负担(the Global Burden of Diseases,GBD)数据库分析中国鼻咽癌的疾病负担,为鼻咽癌的精准防控提供流行病学依据。方法:选取年龄标化发病率、病死率、伤残调整寿命年(disability adjusted life year,DALY)率作为疾病负担的评价指标,按照不同年龄、性别、社会人口学指数及其相关危险因素进行分层分析,同时应用差分自回归移动平均(autoregressive integrated moving average,ARIMA)模型和贝叶斯年龄-时期-队列分析模型(Bayesian age-period-cohort,BAPC)将年龄标化发病率预测至2050年。结果:2021年中国鼻咽癌年龄标化发病率、病死率、DALY率分别为3.4/10万、1.5/10万、48.7/10万,均高于同期全球水平。在所有年龄段,中国男性年龄标化发病率、病死率、DALY率均高于女性。中国鼻咽癌的疾病负担从1990至2021年随着社会人口学指数(socio-demographic index,SDI)的增高逐渐降低。中国归因于饮酒、吸烟、职业甲醛暴露的鼻咽癌疾病负担占比均高于全球水平,且在男性中尤为显著。模型预测中国及全球男性、女性、全人群的年龄标化发病率均提示从2022至2050年呈上升趋势。结论:既往30年中国鼻咽癌的疾病负担随着SDI的升高逐渐降低,但仍高于同期全球水平。同时,中国鼻咽癌的年龄标化发病率在未来30年呈上升趋势。中国仍需进一步增加医疗资源的投入以应对鼻咽癌的防控与诊疗,尤其针对高风险男性群体。
基金Project supported by the National Natural Science Foundation of China (Nos.50375130and50323003), the Special Foundation of National Excellent Ph.D.Thesis (No.200234) and thePlanned Itemforthe Outstanding Young Teachers ofMinistry ofEducationofChina (No.2101)
文摘Experimental study is performed on the probabilistic models for the long fatigue crack growth rates (da/dN) of LZ50 axle steel. An equation for crack growth rate was derived to consider the trend of stress intensity factor range going down to the threshold and the average stress effect. The probabilistic models were presented on the equation. They consist of the probabilistic da/dN-ΔK relations, the confidence-based da/dN-ΔK relations, and the probabilistic- and confidence-based da/dN-ΔK relations. Efforts were made respectively to characterize the effects of probabilistic assessments due to the scattering regularity of test data, the number of sampling, and both of them. These relations can provide wide selections for practice. Analysis on the test data of LZ50 steel indicates that the present models are available and feasible.
文摘为了研究模块化多电平换流器(modular multilevel converter,MMC)在嵌入储能系统(battery energy storage system,BESS)后内部动态特性的变化规律,对MMC-BESS的运行特性进行了详细分析,并提出了一种桥臂级平均值模型(arm average model,AAM)进行验证。首先,在假设桥臂中各储能子模块状态一致的前提下,将离散环节连续化,并根据电路特性方程构建了MMC-BESS的AAM电路模型。然后,根据交流端、直流端以及储能端之间的功率关系对MMC-BESS的运行模式进行划分,建立了桥臂电流与电池功率之间的关系,并对电池功率不均衡状态下的桥臂电流进行了分析。最后,利用Matlab/Simulink分别搭建了MMC-BESS的开关模型和AAM模型,并基于AAM验证了多种工况下的桥臂电流响应。仿真结果表明,AAM在显著提高仿真效率的同时可保证较高的准确性,电池功率的大小与均衡状况对桥臂电流的成分有较大影响。
