Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
A generalized multiple-mode prolate spherical wave functions (PSWFs) multi-carrier with index modulation approach is proposed with the purpose of improving the spectral efficiency of PSWFs multi-carrier systems. The p...A generalized multiple-mode prolate spherical wave functions (PSWFs) multi-carrier with index modulation approach is proposed with the purpose of improving the spectral efficiency of PSWFs multi-carrier systems. The proposed method,based on the optimized multi-index modulation, does not limit the number of signals in the first and second constellations and abandons the concept of limiting the number of signals in different constellations. It successfully increases the spectrum efficiency of the system while expanding the number of modulation symbol combinations and the index dimension of PSWFs signals. The proposed method outperforms the PSWFs multi-carrier index modulation method based on optimized multiple indexes in terms of spectrum efficiency, but at the expense of system computational complexity and bit error performance. For example, with n=10 subcarriers and a bit error rate of 1×10^(-5),spectral efficiency can be raised by roughly 12.4%.展开更多
提出一种光强-波长模型和径向基函数网络(radial basis function network,RBFN)相融合的光谱共焦信号峰值提取算法,简称RBFN-I-λ。首先通过高斯拟合法拟合离散光谱响应信号的差分信号粗略得到初始峰值波长,然后基于泰勒近似法得到理想...提出一种光强-波长模型和径向基函数网络(radial basis function network,RBFN)相融合的光谱共焦信号峰值提取算法,简称RBFN-I-λ。首先通过高斯拟合法拟合离散光谱响应信号的差分信号粗略得到初始峰值波长,然后基于泰勒近似法得到理想峰值波长并计算初始峰值波长和理想峰值波长之间的波长差,最后利用RBFN-I-λ建立光谱共焦响应信号与波长描述误差之间的映射关系。实验结果表明,RBFN-I-λ算法的精度与传统抛物线法、质心法和高斯拟合法等方法相比,至少提升30%。展开更多
频谱兼容波形利用多段离散寂静带宽合成大带宽,在满足带宽要求的同时有效对抗频域密集干扰。为了抑制频谱兼容波形的峰值旁瓣水平,提出一种低峰值旁瓣频谱兼容波形设计方案。所提方案综合考虑波形的自相关峰值旁瓣性能和抗干扰性能,构...频谱兼容波形利用多段离散寂静带宽合成大带宽,在满足带宽要求的同时有效对抗频域密集干扰。为了抑制频谱兼容波形的峰值旁瓣水平,提出一种低峰值旁瓣频谱兼容波形设计方案。所提方案综合考虑波形的自相关峰值旁瓣性能和抗干扰性能,构建加权目标函数。在波形恒模约束下,该问题为非确定多项式难(non-deterministic polynomial-hard,NP-hard)问题。为此,首先利用指数对数平滑技术逼近目标函数,进而提出基于快速傅里叶变换的共轭梯度(conjugate gradient method based on fast Fourier transformation,CGFFT)法求解该问题。此外,波形设计中需要根据性能指标要求选择合适的加权值,为此提出一种加权值自适应确定方法,最后通过数值仿真验证了所提方法的有效性。展开更多
目的探讨光照疗法对阿尔茨海默病患者认知功能的影响,旨在为改善阿尔茨海默病患者的认知功能提供参考。方法计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据知识服务平台、维普网、中国生物医学文献...目的探讨光照疗法对阿尔茨海默病患者认知功能的影响,旨在为改善阿尔茨海默病患者的认知功能提供参考。方法计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库中关于光照疗法对阿尔茨海默病患者认知功能影响的研究,经2名研究员按照纳入及排除标准独立筛选文献、评价文献质量、提取资料,使用RevMan5.4软件进行数据分析。结果最终纳入10篇随机对照试验进行定量分析。结果显示,光照疗法可提升阿尔茨海默病患者简易精神状态量表和蒙特利尔认知评估量表评分(均P<0.05),但阿尔茨海默病评估量表-认知分量表评分干预前后无显著差异。亚组分析结果显示,每次干预时间<30 min,每周干预时长<2 h,光谱范围为近红外光的光照治疗可改善阿尔茨海默病患者认知水平(均P<0.05)。结论光照疗法可以改善阿尔茨海默病患者的认知功能,尤以较短时间近红外光的光照改善显著,但光照强度及频率仍有待确定。展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
基金supported by the China National Postdoctoral Program for Innovative Talents(BX20200039)the Special Fund Project of“Mount Taishan Scholars”Construction Project in Shandong Province(ts20081130).
文摘A generalized multiple-mode prolate spherical wave functions (PSWFs) multi-carrier with index modulation approach is proposed with the purpose of improving the spectral efficiency of PSWFs multi-carrier systems. The proposed method,based on the optimized multi-index modulation, does not limit the number of signals in the first and second constellations and abandons the concept of limiting the number of signals in different constellations. It successfully increases the spectrum efficiency of the system while expanding the number of modulation symbol combinations and the index dimension of PSWFs signals. The proposed method outperforms the PSWFs multi-carrier index modulation method based on optimized multiple indexes in terms of spectrum efficiency, but at the expense of system computational complexity and bit error performance. For example, with n=10 subcarriers and a bit error rate of 1×10^(-5),spectral efficiency can be raised by roughly 12.4%.
文摘提出一种光强-波长模型和径向基函数网络(radial basis function network,RBFN)相融合的光谱共焦信号峰值提取算法,简称RBFN-I-λ。首先通过高斯拟合法拟合离散光谱响应信号的差分信号粗略得到初始峰值波长,然后基于泰勒近似法得到理想峰值波长并计算初始峰值波长和理想峰值波长之间的波长差,最后利用RBFN-I-λ建立光谱共焦响应信号与波长描述误差之间的映射关系。实验结果表明,RBFN-I-λ算法的精度与传统抛物线法、质心法和高斯拟合法等方法相比,至少提升30%。
文摘频谱兼容波形利用多段离散寂静带宽合成大带宽,在满足带宽要求的同时有效对抗频域密集干扰。为了抑制频谱兼容波形的峰值旁瓣水平,提出一种低峰值旁瓣频谱兼容波形设计方案。所提方案综合考虑波形的自相关峰值旁瓣性能和抗干扰性能,构建加权目标函数。在波形恒模约束下,该问题为非确定多项式难(non-deterministic polynomial-hard,NP-hard)问题。为此,首先利用指数对数平滑技术逼近目标函数,进而提出基于快速傅里叶变换的共轭梯度(conjugate gradient method based on fast Fourier transformation,CGFFT)法求解该问题。此外,波形设计中需要根据性能指标要求选择合适的加权值,为此提出一种加权值自适应确定方法,最后通过数值仿真验证了所提方法的有效性。
