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Low-frequency signal generation in space based on high-frequency electric-antenna array and Doppler effect
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作者 CUI Anjing LI Daojing +6 位作者 WU Jiang GAO Jinghan ZHOU Kai HU Chufeng WU Shumei SHI Danni LI Guang 《Journal of Systems Engineering and Electronics》 2025年第1期24-36,共13页
Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting t... Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting their potential applications.Therefore,it is imperative to study the creation of lowfrequency signals using antennas with suitable dimensions.In contrast to conventional mechanical antenna techniques,our study generates low-frequency signals in the spatial domain utilizing the principle of the Doppler effect.We also defines the antenna array architecture,the timing sequency,and the radiating element signal waveform,and provides experimental prototypes including 8/64 antennas based on earlier research.In the conducted experiments,121 MHz,40 MHz,and 10 kHz composite signals are generated by 156 MHz radiating element signals.The composite signal spectrum matches the simulations,proving our low-frequency signal generating method works.This holds significant implications for research on generating low-frequency signals with small-sized antennas. 展开更多
关键词 frequency conversion array signal processing experimental verification Doppler effect
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Downregulation of MUC1 Inhibits Proliferation and Promotes Apoptosis by Inactivating NF-κB Signaling Pathway in Human Nasopharyngeal Carcinoma 被引量:1
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作者 WU Shou-Wu LIN Shao-Kun +11 位作者 NIAN Zhong-Zhu WANG Xin-Wen LIN Wei-Nian ZHUANG Li-Ming WU Zhi-Sheng HUANG Zhi-Wei WANG A-Min GAO Ni-Li CHEN Jia-Wen YUAN Wen-Ting LU Kai-Xian LIAO Jun 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第9期2182-2193,共12页
Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory mechanism.Methods The 60 NPC and paired para-cancer normal tissues were collect... Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory mechanism.Methods The 60 NPC and paired para-cancer normal tissues were collected from October 2020 to July 2021 in Quanzhou First Hospital.The expression of MUC1 was measured by real-time quantitative PCR(qPCR)in the patients with PNC.The 5-8F and HNE1 cells were transfected with siRNA control(si-control)or siRNA targeting MUC1(si-MUC1).Cell proliferation was analyzed by cell counting kit-8 and colony formation assay,and apoptosis was analyzed by flow cytometry analysis in the 5-8F and HNE1 cells.The qPCR and ELISA were executed to analyze the levels of TNF-αand IL-6.Western blot was performed to measure the expression of MUC1,NFкB and apoptosis-related proteins(Bax and Bcl-2).Results The expression of MUC1 was up-regulated in the NPC tissues,and NPC patients with the high MUC1 expression were inclined to EBV infection,growth and metastasis of NPC.Loss of MUC1 restrained malignant features,including the proliferation and apoptosis,downregulated the expression of p-IкB、p-P65 and Bcl-2 and upregulated the expression of Bax in the NPC cells.Conclusion Downregulation of MUC1 restrained biological characteristics of malignancy,including cell proliferation and apoptosis,by inactivating NF-κB signaling pathway in NPC. 展开更多
关键词 mucin 1 nasopharyngeal carcinoma NF-κB signaling pathway PROLIFERATION APOPTOSIS
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Detection method of forward-scatter signal based on Rényi entropy 被引量:2
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作者 ZHENG Yuqing AI Xiaofeng +2 位作者 YANG Yong ZHAO Feng XIAO Shunping 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期865-873,共9页
The application scope of the forward scatter radar(FSR)based on the Global Navigation Satellite System(GNSS)can be expanded by improving the detection capability.Firstly,the forward-scatter signal model when the targe... The application scope of the forward scatter radar(FSR)based on the Global Navigation Satellite System(GNSS)can be expanded by improving the detection capability.Firstly,the forward-scatter signal model when the target crosses the baseline is constructed.Then,the detection method of the for-ward-scatter signal based on the Rényi entropy of time-fre-quency distribution is proposed and the detection performance with different time-frequency distributions is compared.Simula-tion results show that the method based on the smooth pseudo Wigner-Ville distribution(SPWVD)can achieve the best perfor-mance.Next,combined with the geometry of FSR,the influence on detection performance of the relative distance between the target and the baseline is analyzed.Finally,the proposed method is validated by the anechoic chamber measurements and the results show that the detection ability has a 10 dB improvement compared with the common constant false alarm rate(CFAR)detection. 展开更多
关键词 forward scatter radar(FSR) Global Navigation Satellite System(GNSS) time-frequency distribution Rényi entropy signal detection
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Special Section on High-Dimensional Signal Processing
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《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期F0002-F0002,共1页
Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportu... Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportunities to enhance the performance of signal processing in such applications and even motivate new ones.However,the curse of dimensionality is always a challenge when processing such high-dimensional signals.In practical tasks,high-dimensional signals need to be acquired,processed,and analyzed with high accuracy,robustness,and computational efficiency.This special section aims to address these challenges,where articles attempt to develop new theories and methods that are best suited to the high dimensional nature of the signals involved,and explore modern and emerging applications in this area. 展开更多
关键词 signal MASSIVE dimensionality
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The in-depth transmission and reception process of the factors influencing review helpfulness from the signaling timeline perspective
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作者 Mohan Wang Fei Wan +1 位作者 Jiaying Zhang Songyun Xia 《中国科学技术大学学报》 CSCD 北大核心 2024年第10期35-50,I0006,I0007,共18页
Many existing studies have considered the factors influencing review helpfulness,mainly focusing on reviewer impact,review informativeness,and managerial response,based on signaling theory.However,previous studies hav... Many existing studies have considered the factors influencing review helpfulness,mainly focusing on reviewer impact,review informativeness,and managerial response,based on signaling theory.However,previous studies have simply regarded these factors as independent signals,thus ignoring their in-depth transmission and reception processes.The conclusions about the impact of reviewers on review helpfulness are also inconsistent due to the inaccurate measure-ment of variables.To fill the above gaps,we followed the signaling timeline theoretical framework used in signaling the-ory and employed a bootstrapping analysis to examine how reviewer impact,review informativeness,and hotel manageri-al responses interact to influence review helpfulness.In this study,we used a unique dataset that included official labels from one leading online travel agency.The results show that reviewer impact may affect review helpfulness sequentially through review informativeness and hotel managerial response.Furthermore,by using official labels,both reviewer expert-ise and reviewer experience significantly affect review helpfulness.Finally,we discussed the theoretical and practical im-plications of these findings. 展开更多
关键词 signaling timeline review helpfulness reviewer impact review informativeness managerial response
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Automatic modulation recognition of radiation source signals based on two-dimensional data matrix and improved residual neural network
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作者 Guanghua Yi Xinhong Hao +3 位作者 Xiaopeng Yan Jian Dai Yangtian Liu Yanwen Han 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期364-373,共10页
Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the ... Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR. 展开更多
关键词 Automatic modulation recognition Radiation source signals Two-dimensional data matrix Residual neural network Depthwise convolution
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Impact of correlated private signals on continuous-time insider trading
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作者 ZHOU Yonghui XIAO Kai 《运筹学学报(中英文)》 CSCD 北大核心 2024年第3期97-107,共11页
A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establ... A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establish three lemmas:normal corre-lation,equivalent pricing and equivalent profit,which can guarantee to turn our model into a model with insider knowing full information.Then we investigate the impact of the two correlated signals on the market equilibrium consisting of optimal insider trading strategy and semi-strong pricing rule.It shows that in the equilibrium,(1)the market depth is constant over time;(2)if the two noisy signals are not linerly correlated,then all private information of the insider is incorporated into prices in the end while the whole information on the asset value can not incorporated into prices in the end;(3)if the two noisy signals are linear correlated such that the insider can infer the whole information of the asset value,then our model turns into a model with insider knowing full information;(4)if the two noisy signals are the same then the total ex ant profit of the insider is increasing with the noise decreasing,while down to O as the noise going up to infinity;(5)if the two noisy signals are not linear correlated then with one noisy signal fixed,the total ex ante profit of the insider is single-peaked with a unique minimum with respect to the other noisy signal value,and furthermore as the noisy value going to O it gets its maximum,the profit in the case that the real value is observed. 展开更多
关键词 continuous-time insider trading risk neutral private correlated signals linear bayesian equilibrium market depth residual information
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Low-complexity signal detection for massive MIMO systems via trace iterative method
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作者 IMRAN A.Khoso ZHANG Xiaofei +2 位作者 ABDUL Hayee Shaikh IHSAN A.Khoso ZAHEER Ahmed Dayo 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期549-557,共9页
Linear minimum mean square error(MMSE)detection has been shown to achieve near-optimal performance for massive multiple-input multiple-output(MIMO)systems but inevitably involves complicated matrix inversion,which ent... Linear minimum mean square error(MMSE)detection has been shown to achieve near-optimal performance for massive multiple-input multiple-output(MIMO)systems but inevitably involves complicated matrix inversion,which entails high complexity.To avoid the exact matrix inversion,a considerable number of implicit and explicit approximate matrix inversion based detection methods is proposed.By combining the advantages of both the explicit and the implicit matrix inversion,this paper introduces a new low-complexity signal detection algorithm.Firstly,the relationship between implicit and explicit techniques is analyzed.Then,an enhanced Newton iteration method is introduced to realize an approximate MMSE detection for massive MIMO uplink systems.The proposed improved Newton iteration significantly reduces the complexity of conventional Newton iteration.However,its complexity is still high for higher iterations.Thus,it is applied only for first two iterations.For subsequent iterations,we propose a novel trace iterative method(TIM)based low-complexity algorithm,which has significantly lower complexity than higher Newton iterations.Convergence guarantees of the proposed detector are also provided.Numerical simulations verify that the proposed detector exhibits significant performance enhancement over recently reported iterative detectors and achieves close-to-MMSE performance while retaining the low-complexity advantage for systems with hundreds of antennas. 展开更多
关键词 signal detection LOW-COMPLEXITY linear minimum mean square error(MMSE) massive multiple-input multiple-output(MIMO) trace iterative method(TIM)
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Blind radar signal separation algorithm based on third-order degree of cyclostationarity criteria
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作者 FAN Xiangyu LIU Bin +2 位作者 DONG Danna CHEN You WANG Yuancheng 《Journal of Systems Engineering and Electronics》 CSCD 2024年第6期1441-1453,共13页
Separation and recognition of radar signals is the key function of modern radar reconnaissance,which is of great sig-nificance for electronic countermeasures and anti-countermea-sures.In order to improve the ability o... Separation and recognition of radar signals is the key function of modern radar reconnaissance,which is of great sig-nificance for electronic countermeasures and anti-countermea-sures.In order to improve the ability of separating mixed signals in complex electromagnetic environment,a blind source separa-tion algorithm based on degree of cyclostationarity(DCS)crite-rion is constructed in this paper.Firstly,the DCS criterion is con-structed by using the cyclic spectrum theory.Then the algo-rithm flow of blind source separation is designed based on DCS criterion.At the same time,Givens matrix is constructed to make the blind source separation algorithm suitable for multiple sig-nals with different cyclostationary frequencies.The feasibility of this method is further proved.The theoretical and simulation results show that the algorithm can effectively separate and re-cognize common multi-radar signals. 展开更多
关键词 blind signal separation cyclostationary frequency Givens matrix degree of cyclostationarity(DCS)blind source separation algorithm
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基于国产DSP和FPGA的高速信号处理板硬件电路设计 被引量:1
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作者 孙艳萍 边晨通 +1 位作者 屈文涛 宋淑军 《仪表技术与传感器》 北大核心 2025年第5期33-38,共6页
针对目前高速信号处理板多选用国外芯片,国产化程度较低的问题,文中基于DSP和FPGA芯片完成了高速信号处理板国产化设计。首先考虑高速信号处理板应用于人工智能、图像处理等领域,是一种高精度和复杂运算的场景,因此选择DSP芯片FTDOC35BB... 针对目前高速信号处理板多选用国外芯片,国产化程度较低的问题,文中基于DSP和FPGA芯片完成了高速信号处理板国产化设计。首先考虑高速信号处理板应用于人工智能、图像处理等领域,是一种高精度和复杂运算的场景,因此选择DSP芯片FTDOC35BB_FT_M6678为主设计信号处理模块,选择FPGA芯片FMQL45T900为主设计控制单元模块;然后在CANDENCE软件中进一步采用分布式设计硬件电路,完成了高速信号接口模块、DDR3存储模块、EMIF模块的电路设计;最后使用CCS5.5集成开发环境对高速信号处理板各个接口及外设进行了测试。测试指标均达到要求,证明该高速信号处理板国产化设计切实可行,加速了高速信号处理板的国产化进程。 展开更多
关键词 国产化 FPGA DSP 高速信号
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巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路的影响 被引量:1
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作者 冯莹 张妍 +3 位作者 雷杰 刘娟 方勇 贺立群 《中国免疫学杂志》 北大核心 2025年第2期315-319,共5页
目的:探讨巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路和炎症反应的影响。方法:佛波酯诱导THP-1细胞成为巨噬细胞,分别用LPS和IFN-γ、IL-4和IL-13处理48 h,更换不含血清的新鲜培养基培养24 h,取上清作为条件培养基。将血管平... 目的:探讨巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路和炎症反应的影响。方法:佛波酯诱导THP-1细胞成为巨噬细胞,分别用LPS和IFN-γ、IL-4和IL-13处理48 h,更换不含血清的新鲜培养基培养24 h,取上清作为条件培养基。将血管平滑肌细胞分成对照组、M0培养基组、M1培养基组和M2培养基组。CCK-8检测细胞增殖能力,流式细胞术检测细胞凋亡,ELISA检测细胞上清中炎症因子IL-1α、IL-6和TGF-β表达,RT-qPCR和Western blot检测血管平滑肌细胞中PI3K、Akt、mTOR mRNA和磷酸化蛋白表达。结果:与对照组相比,M0培养基组细胞增殖能力、细胞上清中TGF-β水平显著降低(P<0.01),细胞凋亡率、细胞上清中IL-1α和IL-6水平、细胞中PI3K、Akt、mTOR mRNA和蛋白磷酸化水平显著升高(P<0.01);与M0培养基组相比,M1培养基组细胞增殖能力、细胞上清中TGF-β水平显著降低(P<0.05),细胞凋亡率、细胞上清中IL-1α和IL-6水平、细胞中PI3K、Akt、mTOR mRNA和蛋白磷酸化水平显著升高(P<0.01),M2培养基组趋势相反(P<0.05)。结论:巨噬细胞极化能够通过调控PI3K/Akt/mTOR信号通路调节炎症细胞因子表达,参与动脉粥样硬化炎症反应。 展开更多
关键词 巨噬细胞极化 动脉粥样硬化 PI3K/Akt/mTOR信号通路
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径向电流作用下的高压电缆缓冲层烧蚀多物理量信号演变规律 被引量:2
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作者 吴明 洪涵韬 +3 位作者 任志刚 张云飞 李建英 高景晖 《高电压技术》 北大核心 2025年第2期936-945,共10页
近年来高压电缆中缓冲层烧蚀导致的电缆本体击穿事故频发,严重影响了电网的安全稳定运行。缓冲层的含水率及外界压力是影响高压电缆缓冲层烧蚀故障发展的重要因素。基于此,搭建了缓冲层在不同含水率及不同受力下的烧蚀模拟试验平台,研... 近年来高压电缆中缓冲层烧蚀导致的电缆本体击穿事故频发,严重影响了电网的安全稳定运行。缓冲层的含水率及外界压力是影响高压电缆缓冲层烧蚀故障发展的重要因素。基于此,搭建了缓冲层在不同含水率及不同受力下的烧蚀模拟试验平台,研究不同条件下缓冲层烧蚀产生的温度、超声以及电信号,获得了烧蚀缺陷的多物理量演变规律。同时结合对烧蚀缓冲层的微观形貌特征以及烧蚀产物成分的表征,分析了不同条件下的缓冲层烧蚀信号产生的机理,发现电流径向集中引起的热效应和缓冲层内气隙放电是导致缓冲层温度升高的原因,而气隙放电是导致超声信号和电信号产生的原因。研究发现,相较干燥缓冲层烧蚀,含水情况下的缓冲层会和铝护套发生电化学腐蚀,会使得超声信号和电信号变大,且中间会有小的信号产生。该研究为高压电缆缓冲层烧蚀检测装置的开发提供了理论和实验基础。 展开更多
关键词 电力电缆 缓冲层 烧蚀故障 超声信号 径向电流
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基于Nrf2/HO-1和NF-κB信号通路探讨清化止泻方对腹泻型肠易激综合征大鼠巨噬细胞极化的影响 被引量:1
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作者 黄华 王永通 +2 位作者 丁旭枫 蒋捷 季利江 《中成药》 北大核心 2025年第2期438-445,共8页
目的探讨清化止泻方对腹泻型肠易激综合征(IBS-D)大鼠的改善作用及其对M1/M2型巨噬细胞极化的影响。方法SD大鼠随机分为空白组、模型组、匹维溴铵组(20 mg/kg)和清化止泻方低、高剂量组(13.64、27.29 g/kg),每组10只,采用慢性束缚应激... 目的探讨清化止泻方对腹泻型肠易激综合征(IBS-D)大鼠的改善作用及其对M1/M2型巨噬细胞极化的影响。方法SD大鼠随机分为空白组、模型组、匹维溴铵组(20 mg/kg)和清化止泻方低、高剂量组(13.64、27.29 g/kg),每组10只,采用慢性束缚应激加番泻叶水煎剂灌胃法构建IBS-D大鼠模型,各组给予相应剂量药物14 d。观察各组大鼠进食状况、粪便性状和体质量变化;腹部撤离反射(AWR)测定大鼠肠疼痛敏感性;HE染色观察结肠黏膜组织病理学;TUNEL染色观察结肠组织细胞凋亡情况;免疫荧光染色检测大鼠结肠组织ZO-1、Occludin、Nrf2蛋白表达;流式细胞术检测肠系膜淋巴结中M1型和M2巨噬细胞比值;Western blot法检测结肠组织Nrf2、HO-1、p-IκBα、p-P65蛋白表达。结果与模型组比较,清化止泻方各剂量组大鼠体质量、AWR痛觉阈值升高(P<0.05,P<0.01);结肠组织结构基本完整,上皮细胞排列整齐,未见大量细胞变性脱落;结肠组织ZO-1、Occludin蛋白荧光强度增强(P<0.05,P<0.01);结肠组织细胞凋亡率降低(P<0.05,P<0.01);肠系膜淋巴结巨噬细胞向M2极化(P<0.05,P<0.01);结肠组织Nrf2、HO-1蛋白表达升高(P<0.05,P<0.01),p-IκBα/IκBα和p-P65/P65蛋白表达降低(P<0.05,P<0.01)。结论清化止泻方可改善IBS-D大鼠肠上皮黏膜屏障功能,其作用可能与激活Nrf2/HO-1信号通路,抑制NF-κB信号通路活化,调控巨噬细胞向M2极化有关。 展开更多
关键词 清化止泻方 腹泻型肠易激综合征 巨噬细胞 巨噬细胞极化 Nrf2/HO-1信号通路 NF-ΚB信号通路
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基于改进变分模式分解的煤矿通风机振动信号特征提取 被引量:1
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作者 陶珑 郭燕飞 《工矿自动化》 北大核心 2025年第2期131-137,共7页
煤矿通风机振动信号是一种非平稳多分量信号。传统的非平稳信号特征信号提取方法存在自适应性差、对通风机早期故障的微弱特征辨识能力有限等问题,基于广义变分模式分解的特征提取方法的信号处理速度难以满足通风机振动信号特征快速提... 煤矿通风机振动信号是一种非平稳多分量信号。传统的非平稳信号特征信号提取方法存在自适应性差、对通风机早期故障的微弱特征辨识能力有限等问题,基于广义变分模式分解的特征提取方法的信号处理速度难以满足通风机振动信号特征快速提取的要求。针对上述问题,提出了一种基于改进变分模式分解的煤矿通风机振动信号特征快速提取方法。在广义变分模式分解算法的基础上,采用乘子交替方向法迭代求解,将约束优化问题转换为无约束优化问题。应用改进变分模式分解算法对信号进行等效分解,得到匹配目标信号特征的等效滤波器,通过内积变换原理快速提取通风机振动信号特征分量。仿真和实验结果表明,改进变分模式分解算法对不同强度的特征分量提取效果均较好,准确性和抗噪性良好,处理通风机实测振动信号的耗时为0.008165 s,与广义变分模式分解算法相比,特征提取速度大幅提升。 展开更多
关键词 煤矿通风机 振动信号 非平稳信号特征提取 变分模式分解 等效滤波器 内积变换
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基于mTOR/HIF-1α/VEGF信号通路探讨菟丝子醇提物对4T1乳腺癌细胞增殖的抑制作用 被引量:1
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作者 宋辉 黄晓俏 +4 位作者 孙向明 胡扬 单文猜 汤静 李文兰 《食品工业科技》 北大核心 2025年第7期355-364,共10页
目的:通过体内外实验,探讨菟丝子醇提物对4T1乳腺癌细胞增殖的抑制作用及机制。方法:体外采用MTT、划痕、Transwell、流式细胞术实验分别研究菟丝子醇提物对4T1乳腺癌细胞增殖、迁移、侵袭、凋亡的影响;体内建立4T1荷瘤小鼠模型,菟丝子... 目的:通过体内外实验,探讨菟丝子醇提物对4T1乳腺癌细胞增殖的抑制作用及机制。方法:体外采用MTT、划痕、Transwell、流式细胞术实验分别研究菟丝子醇提物对4T1乳腺癌细胞增殖、迁移、侵袭、凋亡的影响;体内建立4T1荷瘤小鼠模型,菟丝子醇提物灌胃给药14 d后,ELISA试剂盒检测小鼠血清中肿瘤坏死因子-alpha(Tumor necrosis factor-alpha,TNF-α)、白介素2(Interleukin-2,IL-2)、白介素10(Interleukin-10,IL-10)的浓度。同时将模型组、菟丝子醇提物高剂量组瘤组织进行转录组测序分析,筛选差异基因,进行GO和KEGG富集分析,采用Western Blot法对mTOR/HIF-1α/VEGF信号通路进行实验验证。结果:与空白组相比,菟丝子醇提物(400、800、1200μg/mL)能够显著抑制4T1乳腺癌细胞增殖、迁移、侵袭(P<0.05,P<0.01),促进细胞凋亡(P<0.01)。体内实验显示,与模型组相比,菟丝子醇提物(6.24、12.48 g/kg)可显著提高小鼠血清中TNF-α、IL-2、IL-10(P<0.05,P<0.01)的含量;转录组筛选出差异基因512个,其中上调154个,下调358个;GO富集分析共富集到1870个条目;KEGG富集分析富集到Cytokine-cytokine receptor interaction、HIF-1signaling pathway、IL-17 signaling pathway等信号通路;菟丝子醇提物能够降低瘤组织中p-mTOR、HIF-1α、pRPS6K、p-P70S6K、VEGF、VEGFR2蛋白表达(P<0.05,P<0.01),具有剂量依赖性。结论:菟丝子醇提物可抑制4T1乳腺癌细胞增殖,升高小鼠血清中炎症因子表达,其机制与调控mTOR/HIF-1α/VEGF信号通路有关。 展开更多
关键词 菟丝子 乳腺癌 转录组 mTOR/HIF-1α/VEGF信号通路
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一种高速全差分输出线列型读出电路设计方法 被引量:1
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作者 王静 孟令伟 +2 位作者 刘伟 李冬冰 李敬国 《激光与红外》 北大核心 2025年第2期239-242,共4页
红外探测器发展进入第三代后,以大面阵、长线列应用为典型代表,其中长线列通常使用拼接结构实现。对于参与拼接的单片电路规模也在不断的扩展、行频不断的提升。阵列规格的增加带来信号传输链路延长,行频提升对读出速率提出新的要求,这... 红外探测器发展进入第三代后,以大面阵、长线列应用为典型代表,其中长线列通常使用拼接结构实现。对于参与拼接的单片电路规模也在不断的扩展、行频不断的提升。阵列规格的增加带来信号传输链路延长,行频提升对读出速率提出新的要求,这些还必须考虑探测器的低温应用,要求读出电路提出更加合理有效的应对措施。本文探索了一种新的输出机制,针对长线列的应用,可以通过全差分输出抑制传输噪声,同时差分模块转换模块独立于探测器主芯片,在不影响芯片整体热耗的前提下,显著的提升读出速率。依赖于这种设计,线列读出速率提升至20 MHz,对于1 k的规模,行频达到19 kHz。 展开更多
关键词 线列读出电路 全差分输出 信号转换 拼接电路
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GNSS接收机多通道确定性压缩PMF-FFT捕获方法 被引量:1
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作者 张琦 张文俊 +3 位作者 陈劼 张风源 王进 张小贝 《中国惯性技术学报》 北大核心 2025年第2期124-132,共9页
针对目前全球导航卫星系统(GNSS)接收机在快速捕获过程中消耗大量硬件资源的问题,提出了一种基于确定性压缩感知的多通道部分匹配滤波-快速傅里叶变换(PMF-FFT)捕获方法。首先利用沃尔什-阿达马矩阵对多通道PMF-FFT的本地伪码矩阵进行... 针对目前全球导航卫星系统(GNSS)接收机在快速捕获过程中消耗大量硬件资源的问题,提出了一种基于确定性压缩感知的多通道部分匹配滤波-快速傅里叶变换(PMF-FFT)捕获方法。首先利用沃尔什-阿达马矩阵对多通道PMF-FFT的本地伪码矩阵进行确定性压缩,并将压缩后的伪码矩阵按照PMF-FFT方法进行粗捕获,然后对粗捕获相位区间进行精捕获搜索,最后推导出所提方法的理论分析模型,并通过蒙特卡洛仿真进行验证。理论分析和仿真测试结果表明,在捕获性能相同的情况下,所提方法较二维捕获算法和PMF-FFT算法在硬件资源消耗上分别减少了70.33%和41.67%以上。 展开更多
关键词 全球导航卫星系统 多通道PMF-FFT 压缩感知 信号捕获
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基于自适应多尺度形态学梯度乘积运算的发电机振动信号特征增强检测 被引量:1
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作者 王晓龙 石海超 +4 位作者 熊江涛 金韩微 张博文 陆志鹏 何玉灵 《中国电机工程学报》 北大核心 2025年第8期3195-3204,I0028,共11页
针对发电机发生定子匝间短路故障时振动信号特征微弱的问题,提出一种基于自适应多尺度形态学梯度乘积运算的发电机振动信号特征增强检测方法。首先,根据发电机定子的振动特征设计一种新颖的星形结构元素,并构建多尺度形态学梯度乘积运... 针对发电机发生定子匝间短路故障时振动信号特征微弱的问题,提出一种基于自适应多尺度形态学梯度乘积运算的发电机振动信号特征增强检测方法。首先,根据发电机定子的振动特征设计一种新颖的星形结构元素,并构建多尺度形态学梯度乘积运算方式;其次,利用白鲨优化策略对星形结构元素的幅值及尺度进行寻优,并将自适应多尺度形态学梯度乘积运算应用在发电机定子振动信号特征增强检测中;最后,对比发电机定子匝间短路理论故障特征频率与处理信号频谱中幅值突出的频率,判断发电机的运行状态。实验证明,所提方法可有效增强发电机定子振动信号特征,提高发电机定子匝间短路故障检出率,具有一定工程参考价值。 展开更多
关键词 发电机 振动信号 数学形态学 星形结构元素
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基于微波光子信号稳相传输的多路信号增强技术
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作者 欧阳竑 谢仕锋 +6 位作者 王侠 曾永福 李跃 尹思杰 代丰羽 杨万里 尹怡辉 《光通信技术》 北大核心 2025年第2期81-84,共4页
针对信号在光纤中传输时受到外部环境因素影响,导致传输的光载射频信号相位出现抖动,影响多路信号相干叠加后的信噪比问题,提出一种基于微波光子信号稳相传输的多路信号增强技术。通过设计包含相位测量、控制与调节模块的稳相传输系统,... 针对信号在光纤中传输时受到外部环境因素影响,导致传输的光载射频信号相位出现抖动,影响多路信号相干叠加后的信噪比问题,提出一种基于微波光子信号稳相传输的多路信号增强技术。通过设计包含相位测量、控制与调节模块的稳相传输系统,结合闭环测量和精度调节(粗调10 ps、精调0.1 ps),实现光载射频信号的相位稳定;进一步搭建多路信号传输系统,采用匹配滤波和相位精确合成方法,完成3路信号的相干叠加。实验结果表明:在1.7、2.3 GHz频率下,叠加后的信号功率较单路信号分别提升4.5、5.1 d B,信噪比分别改善2.8、3.44 d B。 展开更多
关键词 微波光子 稳相传输 多路信号 信号增强
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快艇螺旋桨线谱特性分析及检测
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作者 陈新华 李嶷 +2 位作者 郑恩明 方华 杨鹤 《哈尔滨工程大学学报》 北大核心 2025年第4期660-666,共7页
为了获得目标声纹特征,本文对快艇的湖上试验数据进行分析。利用低频分析记录图研究实际工作中目标线谱在图中的表现,同时针对快艇工况稳定和转向时的2种情况,研究快艇螺旋桨各时刻的线谱特性。采用长时间数据和短时间数据做快速傅里叶... 为了获得目标声纹特征,本文对快艇的湖上试验数据进行分析。利用低频分析记录图研究实际工作中目标线谱在图中的表现,同时针对快艇工况稳定和转向时的2种情况,研究快艇螺旋桨各时刻的线谱特性。采用长时间数据和短时间数据做快速傅里叶变换的方法对线谱进行检测,验证不同试验场景下这2种方法检测线谱的性能优劣,提出对长时间数据做快速傅里叶变换的工程实现方法。研究表明:目标线谱会随着目标工况的变化而发生漂移;低频分析记录图中线谱的基频和谐波信号强度具有随机性;在目标工况稳定或变化剧烈时宜分别采用长时间或短时间傅里叶变换进行线谱检测。本文为目标检测和识别提供理论和实践指导。 展开更多
关键词 信号处理 频谱分析 信号检测 水下声信号 螺旋桨 舰船噪声 线谱 低频分析记录图
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