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ESCRT Mechanism-mediated Repair of Plasma Membrane Damage Induced by Regulatory Cell Death
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作者 FENG Tian-Yang DENG Le +2 位作者 XU Gou LI Li GUO Miao-Miao 《生物化学与生物物理进展》 北大核心 2025年第5期1099-1112,共14页
The plasma membrane(PM)plays an essential role in maintaining cell homeostasis,therefore,timely and effective repair of damage caused by factors such as mechanical rupture,pore-forming toxins,or pore-forming proteins ... The plasma membrane(PM)plays an essential role in maintaining cell homeostasis,therefore,timely and effective repair of damage caused by factors such as mechanical rupture,pore-forming toxins,or pore-forming proteins is crucial for cell survival.PM damage induces membrane rupture and stimulates an immune response.However,damage resulting from regulated cell death processes,including pyroptosis,ferroptosis,and necroptosis,cannot be repaired by simple sealing mechanisms and thus,requires specialized repair machinery.Recent research has identified a PM repair mechanism of regulated cell death-related injury,mediated by the endosomal sorting complexes required for transport(ESCRT)machinery.Here,we review recent progress in elucidating the ESCRT machinery-mediated repair mechanism of PM injury,with particular focus on processes related to regulated cell death.This overview,along with continued research in this field,may provide novel insights into therapeutic targets for diseases associated with dysregulation of regulated cell death pathways. 展开更多
关键词 ESCRT PYROPTOSIS ferroptosis NECROPTOSIS plasma membrane repair
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Optimized joint repair effects on damage evolution and arching mechanism of CRTS II slab track under extreme thermal conditions
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作者 CAI Xiao-pei CHEN Ze-lin +3 位作者 CHEN Bo-jing ZHONG Yang-long ZHOU Rui HUANG Yi-chen 《Journal of Central South University》 2025年第6期2273-2287,共15页
To address the issue of extreme thermal-induced arching in CRTS II slab tracks due to joint damage,an optimized joint repair model was proposed.First,the formula for calculating the safe temperature rise of the track ... To address the issue of extreme thermal-induced arching in CRTS II slab tracks due to joint damage,an optimized joint repair model was proposed.First,the formula for calculating the safe temperature rise of the track was derived based on the principle of stationary potential energy.Considering interlayer evolution and structural crack propagation,an optimized joint repair model for the track was established and validated.Subsequently,the impact of joint repair on track damage and arch stability under extreme temperatures was studied,and a comprehensive evaluation of the feasibility of joint repair and the evolution of damage after repair was conducted.The results show that after the joint repair,the temperature rise of the initial damage of the track structure can be increased by 11℃.Under the most unfavorable heating load with a superimposed temperature gradient,the maximum stiffness degradation index SDEG in the track structure is reduced by about 81.16%following joint repair.The joint repair process could effectively reduce the deformation of the slab arching under high temperatures,resulting in a reduction of 93.96%in upward arching deformation.After repair,with the damage to interfacing shear strength,the track arch increases by 2.616 mm. 展开更多
关键词 CRTS II slab track optimized joint repair arching mechanism temperature load damage initiation and evolution
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Reliability Analysis of a Cold Standby Repairable System with Repairman Extra Work 被引量:14
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作者 ZHANG Xin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第5期1015-1032,共18页
This paper deals with a cold standby repairman who can do extra work in idle time. The repairable system with two identical units and one authors are devoted to studying the unique existence and exponential stability ... This paper deals with a cold standby repairman who can do extra work in idle time. The repairable system with two identical units and one authors are devoted to studying the unique existence and exponential stability of the system solution. C0-semigroup theory is used to prove the existence of a unique nonnegative time-dependent solution of the system. Then by using the theory of resolvent positive operator, the authors derive that dynamic solution of the system exponentially converges to its steady-state one which is the eigenfunction corresponding to eigenvalue 0 of the system operator. Some reliability indices of the system are discussed with a different method from traditional one. The authors also make a profit analysis to determine the optimal service time outside the system to maximize the system profit. 展开更多
关键词 C0-SEMIGROUP exponential stability repairable system resolvent positive operator.
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Markov repairable systems with stochastic regimes switching 被引量:5
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作者 Liying Wang Lirong Cui Mingli Yu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第5期773-779,共7页
Compared with the classical Markov repairable system, the Markov repairable system with stochastic regimes switching introduced in the paper provides a more realistic description of the practical system. The system ca... Compared with the classical Markov repairable system, the Markov repairable system with stochastic regimes switching introduced in the paper provides a more realistic description of the practical system. The system can be used to model the dynamics of a repairable system whose performance regimes switch according to the external conditions. For example, to satisfy the demand variation that is typical for the power and communication systems and reduce the cost, these systems usually adjust their operating regimes. The transition rate matrices under distinct operating regimes are assumed to be different and the sojourn times in distinct regimes are governed by a finite state Markov chain. By using the theory of Markov process, Ion channel theory, and Laplace transforms, the up time of the system are studied. A numerical example is given to illustrate the obtained results. The effect of sojourn times in distinct regimes on the availability and the up time are also discussed in the numerical example. 展开更多
关键词 Markov repairable system up time stochastic regimes switching system Markov process.
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A novel reaching law approach of quasi-sliding-mode control for uncertain discrete-time systems 被引量:4
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作者 袁雷 沈建清 +1 位作者 肖飞 王恒利 《Journal of Central South University》 SCIE EI CAS 2012年第9期2514-2519,共6页
A novel discrete-time reaching law was proposed for uncertain discrete-time system,which contained process noise and measurement noise.The proposed method reserves all the advantages of discrete-time reaching law,whic... A novel discrete-time reaching law was proposed for uncertain discrete-time system,which contained process noise and measurement noise.The proposed method reserves all the advantages of discrete-time reaching law,which not only decreases the band width of sliding mode and strengthens the system robustness,but also improves the dynamic performance and stability capability of the system.Moreover,a discrete-time sliding mode control strategy based on Kalman filter method was designed,and Kalman filter was employed to eliminate the influence of system noise.Simulation results show that there is no chattering phenomenon in the output of controller and the state variables of controlled system,and the proposed algorithm is also feasible and has strong robustness to external disturbances. 展开更多
关键词 discrete-time system quasi-sliding-mode control discrete-time reaching law Kalman filter
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Attitude sensor fault diagnosis based on Kalman filter of discrete-time descriptor system 被引量:8
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作者 ZhenhuaWang Yi Shen Xiaolei Zhang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第6期914-920,共7页
To diagnose the fault of attitude sensors in satellites, this paper proposes a novel approach based on the Kalman filter of the discrete-time descriptor system. By regarding the sensor fault term as the auxiliary stat... To diagnose the fault of attitude sensors in satellites, this paper proposes a novel approach based on the Kalman filter of the discrete-time descriptor system. By regarding the sensor fault term as the auxiliary state vector, the attitude measurement system subjected to the attitude sensor fault is modeled by the discrete-time descriptor system. The condition of estimability of such systems is given. And then a Kalman filter of the discrete-time descriptor system is established based on the methodology of the maximum likelihood estimation. With the descriptor Kalman filter, the state vector of the original system and sensor fault can be estimated simultaneously. The proposed method is able to esti-mate an abrupt sensor fault as well as the incipient one. Moreover, it is also effective in the multiple faults scenario. Simulations are conducted to confirm the effectiveness of the proposed method. 展开更多
关键词 discrete-time descriptor system Kalman filter satel-lite attitude sensor fault estimation.
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Stability analysis and stabilization for discrete-time singular delay systems 被引量:3
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作者 Xin Sun Qingling Zhang +1 位作者 Chunyu Yang Zhan Su 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第3期482-487,共6页
Stability analysis and stabilization for discrete-time singular delay systems are addressed,respectively.Firstly,a sufficient condition for regularity,causality and stability for discrete-time singular delay systems i... Stability analysis and stabilization for discrete-time singular delay systems are addressed,respectively.Firstly,a sufficient condition for regularity,causality and stability for discrete-time singular delay systems is derived.Then,by applying the skill of matrix theory,the state feedback controller is designed to guarantee the closed-loop discrete-time singular delay systems to be regular,casual and stable.Finally,numerical examples are given to demonstrate the effectiveness of the proposed method. 展开更多
关键词 discrete-time singular systems DELAY STABILITY stabilization.
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Composite nonlinear feedback control for output regulation problem of linear discrete-time systems with input saturation 被引量:2
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作者 Chongwen Wang Xing Chu Weiyao Lan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第6期1043-1055,共13页
Transient performance for output regulation problems of linear discrete-time systems with input saturation is addressed by using the composite nonlinear feedback(CNF) control technique. The regulator is designed to ... Transient performance for output regulation problems of linear discrete-time systems with input saturation is addressed by using the composite nonlinear feedback(CNF) control technique. The regulator is designed to be an additive combination of a linear regulator part and a nonlinear feedback part. The linear regulator part solves the regulation problem independently which produces a quick output response but large oscillations. The nonlinear feedback part with well-tuned parameters is introduced to improve the transient performance by smoothing the oscillatory convergence. It is shown that the introduction of the nonlinear feedback part does not change the solvability conditions of the linear discrete-time output regulation problem. The effectiveness of transient improvement is illustrated by a numeric example. 展开更多
关键词 output regulation composite nonlinear feedback in-put saturation transient performance discrete-time system
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Static output feedback control for discrete-time fuzzy bilinear system 被引量:4
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作者 Guo Zhang Mingli Song 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第2期296-299,共4页
The problem of designing fuzzy static output feedback controller for T-S discrete-time fuzzy bilinear system (DFBS) is presented. Based on parallel distribution compensation method, some sufficient conditions are de... The problem of designing fuzzy static output feedback controller for T-S discrete-time fuzzy bilinear system (DFBS) is presented. Based on parallel distribution compensation method, some sufficient conditions are derived to guarantee the stability of the overall fuzzy system. The stabilization conditions are further formulated into linear matrix inequality (LMI) so that the desired controller can be easily obtained by using the Matlab LMI toolbox. In comparison with the existing results, the drawbacks, such as coordinate transformation, same output matrices, have been elim- inated. Finally, a simulation example shows that the approach is effective. 展开更多
关键词 discrete-time fuzzy bilinear system (DFBS) static out- put feedback control fuzzy control linear matrix inequality (LMI).
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Non-fragile guaranteed cost control of discrete-time fuzzy bilinear system 被引量:5
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作者 Guo Zhang Junmin Li 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第4期629-634,共6页
This paper focuses on the problem of non-fragile guaranteed cost control for a class of T-S discrete-time fuzzy bilinear systems(DFBS).Based on the parallel distributed compensation(PDC) approach,the sufficient co... This paper focuses on the problem of non-fragile guaranteed cost control for a class of T-S discrete-time fuzzy bilinear systems(DFBS).Based on the parallel distributed compensation(PDC) approach,the sufficient conditions are derived such that the closed-loop system is asymptotically stable and the cost function value is no more than a certain upper bound in the presence of the additive controller gain perturbations.The non-fragile guaranteed cost controller can be obtained by solving a set of bilinear matrix inequalities(BMIs).The Van de Vusse model is utilized to demonstrate the validity and effectiveness of the proposed approach. 展开更多
关键词 discrete-time fuzzy bilinear system(DFBS) nonfragile control guaranteed cost control bilinear matrix inequality(BMI).
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Robust reliable H_∞ control for discrete-time Markov jump linear systems with actuator failures 被引量:2
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作者 Chen Jiaorong Liu Fei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第5期965-973,共9页
The robust reliable H∞ control problem for discrete-time Markovian jump systems with actuator failures is studied. A more practical model of actuator failures than outage is considered. Based on the state feedback me... The robust reliable H∞ control problem for discrete-time Markovian jump systems with actuator failures is studied. A more practical model of actuator failures than outage is considered. Based on the state feedback method, the resulting closed-loop systems are reliable in that they remain robust stochastically stable and satisfy a certain level of H∞ disturbance attenuation not only when all actuators are operational, but also in case of some actuator failures, The solvability condition of controllers can be equivalent to a feasibility problem of coupled linear matrix inequalities (LMIs). A numerical example is also given to illustrate the design procedures and their effectiveness. 展开更多
关键词 discrete-time Markov jump systems actuator failure reliable control robust H∞-control time-delay.
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Robust stability and stabilization for uncertain discrete-time switched singular systems with time-varying delays 被引量:2
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作者 Jinxing Lin Shumin Fei Jiong Shen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第4期650-657,共8页
The problems of robust stability and stabilization via memoryless state feedback for a class of discrete-time switched singular systems with time-varying delays and linear fractional uncertainties are investigated.By ... The problems of robust stability and stabilization via memoryless state feedback for a class of discrete-time switched singular systems with time-varying delays and linear fractional uncertainties are investigated.By constructing a novel switched Lyapunov-Krasovskii functional,a delay-dependent criterion for the unforced system to be regular,causal and uniformly asymptotically stable is established in terms of linear matrix inequalities(LMIs).An explicit expression for the desired memoryless state feedback stabilization controller is also given.The merits of the proposed criteria lie in their less conservativeness and relative simplicity,which are achieved by considering additionally useful terms(ignored in previous methods) when estimating the upper bound of the forward difference of the Lyapunov-Krasovskii functional and by avoiding utilizing any model augmentation transformation.Some numerical examples are provided to illustrate the validity of the proposed methods. 展开更多
关键词 discrete-time switched singular system time-varying delay delay-dependent criterion switched Lyapunov-Krasovskii functional robust stability stabilization.
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Indirect adaptive fuzzy control for a class of nonlinear discrete-time systems 被引量:1
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作者 Shi Wuxi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第6期1203-1207,共5页
An indirect adaptive fuzzy control scheme is developed for a class of nonlinear discrete-time systems. In this method, two fuzzy logic systems are used to approximate the unknown functions, and the parameters of membe... An indirect adaptive fuzzy control scheme is developed for a class of nonlinear discrete-time systems. In this method, two fuzzy logic systems are used to approximate the unknown functions, and the parameters of membership functions in fuzzy logic systems are adjusted according to adaptive laws for the purpose of controlling the plant to track a reference trajectory. It is proved that the scheme can not only guarantee the boundedness of the input and output of the closed-loop system, but also make the tracking error converge to a small neighborhood of the origin. Simulation results indicate the effectiveness of this scheme. 展开更多
关键词 nonlinear discrete-time systems adaptive fuzzy control stability analysis.
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Adaptive control for a class of discrete-time time-delay systems with regard to delay parameter 被引量:1
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作者 Chai Lin Cheng Ming +1 位作者 Fei Shumin Zhai Junyong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期159-167,共9页
The memory state feedback control problem for a class of discrete-time systems with input delay and unknown state delay is addressed based on LMIs and Lyapunov-Krasovskii functional method. Under the action of our des... The memory state feedback control problem for a class of discrete-time systems with input delay and unknown state delay is addressed based on LMIs and Lyapunov-Krasovskii functional method. Under the action of our designed adaptive control law, the unknown time-delay parameter is included in memory state feedback controller. Using LMI technique, delay-dependent sufficient conditions for the existence of the feedback controller are obtained. Finally, the effectiveness of the proposed design method is demonstrated by a numerical example. 展开更多
关键词 discrete-time time-delay systems adaptive control linear matrix inequality.
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Adaptive learning with guaranteed stability for discrete-time recurrent neural networks 被引量:1
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作者 邓华 吴义虎 段吉安 《Journal of Central South University of Technology》 EI 2007年第5期685-689,共5页
To avoid unstable learning, a stable adaptive learning algorithm was proposed for discrete-time recurrent neural networks. Unlike the dynamic gradient methods, such as the backpropagation through time and the real tim... To avoid unstable learning, a stable adaptive learning algorithm was proposed for discrete-time recurrent neural networks. Unlike the dynamic gradient methods, such as the backpropagation through time and the real time recurrent learning, the weights of the recurrent neural networks were updated online in terms of Lyapunov stability theory in the proposed learning algorithm, so the learning stability was guaranteed. With the inversion of the activation function of the recurrent neural networks, the proposed learning algorithm can be easily implemented for solving varying nonlinear adaptive learning problems and fast convergence of the adaptive learning process can be achieved. Simulation experiments in pattern recognition show that only 5 iterations are needed for the storage of a 15×15 binary image pattern and only 9 iterations are needed for the perfect realization of an analog vector by an equilibrium state with the proposed learning algorithm. 展开更多
关键词 recurrent neural networks adaptive learning nonlinear discrete-time systems pattern recognition
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Robust H_∞ filtering for discrete-time systems with Markovian switching and time-delays 被引量:1
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作者 Yao Xiuming Zhao Fu +1 位作者 Ling Mingxiang Wang Changhong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第5期1072-1080,共9页
The robust H∞ filtering problem for uncertain discrete-time Markovian jump linear systems with mode- dependent time-delays is investigated. Attention is focused on designing a Markovian jump linear filter that ensure... The robust H∞ filtering problem for uncertain discrete-time Markovian jump linear systems with mode- dependent time-delays is investigated. Attention is focused on designing a Markovian jump linear filter that ensures robust stochastic stability while achieving a prescribed H∞ performance level of the resulting filtering error system, for all admissible uncertainties. The key features of the approach include the introduction of a new type of stochastic Lyapunov functional and some free weighting matrix variables. Sufficient conditions for the solvability of this problem are obtained in terms of a set of linear matrix inequalities. Numerical examples are provided to demonstrate the reduced conservatism of the proposed approach. 展开更多
关键词 discrete-time Markovian jump linear system robust H∞ filtering mode-dependent delay linear matrix inequality.
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Reliability Analysis of Some Typical Repairable Systems with Arbitrary Repair-Time Distribution
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作者 Wang Jing and Yang DeliInst. of Systems Eng., Dalian Univ. of Tech., Dalian 116023, China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1992年第4期61-72,共12页
In this paper, reliability of some typical non-Markov repairable systems, including series systems, m-out-of- n or majority vote systems, and n : m cross-strapping standby redundant systems with general repair-time di... In this paper, reliability of some typical non-Markov repairable systems, including series systems, m-out-of- n or majority vote systems, and n : m cross-strapping standby redundant systems with general repair-time distribution, are studied by applying the generalized Markov renewal process (GMRP). The stochastic behavior of the typical systems is analyzed here. Formulas for mean time to first system failure, MTBF, MTTR, and availability are then developed. 展开更多
关键词 repairable systems Reliability analysis Markov processes.
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Robust stability of discrete-time nonlinear system with time-delay
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作者 LIU Xin-ge WU Min 《Journal of Central South University of Technology》 2005年第z1期227-231,共5页
The robustly asymptotical stability problem for discrete-time nonlinear systems with time-delay was investigated. Positive definite matrix are constructed through Lyapunov functional. With the identity transform, prop... The robustly asymptotical stability problem for discrete-time nonlinear systems with time-delay was investigated. Positive definite matrix are constructed through Lyapunov functional. With the identity transform, property of matrix inverse and S-procedure, a new sufficient condition independent of the size of time-delay for robust stability of discrete-time nonlinear systems with time-delay is established. With Schur complement, another equivalent sufficient condition for robust stability of discrete-time nonlinear systems with time-delay is given. Finally, a sufficient condition dependent on the size of time-delay for robust stability of discrete-time nonlinear systems with time-delay is obtained. A unified approach is used to cast the robust stability problem into a convex optimization involving linear matrix inequalities. 展开更多
关键词 discrete-time system TIME-DELAY robust stability linear MATRIX INEQUALITY
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Improved results on passivity analysis of discrete-time stochastic neural networks with time-varying delay
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作者 于建江 张侃健 费树岷 《中南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2009年第S1期63-67,共5页
The problem of passivity analysis for a class of discrete-time stochastic neural networks (DSNNs) with time-varying interval delay was investigated. The delay-dependent sufficient criteria were derived in terms of lin... The problem of passivity analysis for a class of discrete-time stochastic neural networks (DSNNs) with time-varying interval delay was investigated. The delay-dependent sufficient criteria were derived in terms of linear matrix inequalities (LMIs). The results are shown to be generalization of some previous results and are less conservative than the existing works. Meanwhile, the computational complexity of the obtained stability conditions is reduced because less variables are involved. A numerical example is given to show the effectiveness and the benefits of the proposed method. 展开更多
关键词 PASSIVITY discrete-time stochastic neural networks (DSNNs) INTERVAL delay linear matrix INEQUALITIES (LMIs)
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Attractors and the attraction basins of discrete-time cellular neural networks
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作者 MaRunnian XiYoumin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2005年第1期204-208,共5页
The dynamic behavior of discrete-time cellular neural networks(DTCNN), which is strict with zero threshold value, is mainly studied in asynchronous mode and in synchronous mode. In general, a k-attractor of DTCNN is n... The dynamic behavior of discrete-time cellular neural networks(DTCNN), which is strict with zero threshold value, is mainly studied in asynchronous mode and in synchronous mode. In general, a k-attractor of DTCNN is not a convergent point. But in this paper, it is proved that a k-attractor is a convergent point if the strict DTCNN satisfies some conditions. The attraction basin of the strict DTCNN is studied, one example is given to illustrate the previous conclusions to be wrong, and several results are presented. The obtained results on k-attractor and attraction basin not only correct the previous results, but also provide a theoretical foundation of performance analysis and new applications of the DTCNN. 展开更多
关键词 discrete-time cellular neural networks convergent point k-attractor attraction basin.
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