Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)G...Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.展开更多
目的:探讨双源CT多期增强双能量成像在鉴别肺癌与肺炎性结节/肿块的应用价值。方法:对42例肺结节或肿块患者行双能量平扫及肺动脉期(PP)、主动脉期(AP)、静脉期(VP)及延迟期(DP)增强扫描。测量感兴趣区的平扫CT值、PP、AP、VP及DP的标...目的:探讨双源CT多期增强双能量成像在鉴别肺癌与肺炎性结节/肿块的应用价值。方法:对42例肺结节或肿块患者行双能量平扫及肺动脉期(PP)、主动脉期(AP)、静脉期(VP)及延迟期(DP)增强扫描。测量感兴趣区的平扫CT值、PP、AP、VP及DP的标准化碘浓度(NIC)及40 keV、100 keV图像CT值,计算PP、AP、VP及DP的40 keV图像净增CT值(d_(CT))和40~100 keV区间的能谱曲线斜率(λ_(HU))。比较两组间各参数的差异并进行统计学分析。结果:经手术切除或穿刺活检病理证实,或通过临床诊治过程明确诊断,肺癌组22例、炎性组20例。PP、AP、VP及DP的NIC值、CT值40 ke V、CT值100 ke V炎性组均高于肺癌组;AP、VP及DP的d_(CT)值及λ_(HU)炎性组高于肺癌组,PP的d_(CT)值及λ_(HU)炎性组略低于肺癌组;炎性组与肺癌组比较,VP及DP的NIC值、d_(CT)值差异有统计学意义(P<0.05)。结论:多期增强双能量成像对肺癌与肺炎性结节/肿块的鉴别诊断具有较大的应用价值。展开更多
文摘Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.
文摘目的:探讨双源CT多期增强双能量成像在鉴别肺癌与肺炎性结节/肿块的应用价值。方法:对42例肺结节或肿块患者行双能量平扫及肺动脉期(PP)、主动脉期(AP)、静脉期(VP)及延迟期(DP)增强扫描。测量感兴趣区的平扫CT值、PP、AP、VP及DP的标准化碘浓度(NIC)及40 keV、100 keV图像CT值,计算PP、AP、VP及DP的40 keV图像净增CT值(d_(CT))和40~100 keV区间的能谱曲线斜率(λ_(HU))。比较两组间各参数的差异并进行统计学分析。结果:经手术切除或穿刺活检病理证实,或通过临床诊治过程明确诊断,肺癌组22例、炎性组20例。PP、AP、VP及DP的NIC值、CT值40 ke V、CT值100 ke V炎性组均高于肺癌组;AP、VP及DP的d_(CT)值及λ_(HU)炎性组高于肺癌组,PP的d_(CT)值及λ_(HU)炎性组略低于肺癌组;炎性组与肺癌组比较,VP及DP的NIC值、d_(CT)值差异有统计学意义(P<0.05)。结论:多期增强双能量成像对肺癌与肺炎性结节/肿块的鉴别诊断具有较大的应用价值。
