摘要
目的:探究非小细胞肺癌(NSCLC)—患者^(18)F-FDG PET/CT参数与癌组织肿瘤增殖抗原(Ki-67)、程序性死亡配体1(PD-L1)表达的关系。方法:纳入2021年9月—2024年4月我院收治的72例NSCLC患者进行研究。对比不同病理类型患者的^(18)F-FDG PET/CT参数、临床分期、肿瘤直径和分化程度。使用免疫组化法检测患者的Ki-67、PD-L1表达。将Ki-67≥50%的患者纳入Ki-67高表达组(41例),将Ki-67<50%的患者纳入Ki-67低表达组(31例),对比2组患者的^(18)F-FDG PET/CT参数(最大标准摄取值(SUVmax)、肿瘤代谢体积(MTV)、糖酵解总量(TLG))。根据PD-L1检测结果将患者分为PD-L1阴性组(13例)、PD-L1低表达组(27例)、PD-L1高表达组(32例),对比3组患者的^(18)F-FDG PET/CT参数。使用Spearman分析^(18)F-FDG PET/CT参数与Ki-67、PD-L1表达的相关性。结果:肺鳞癌患者的SUVmax、MTV、TLG、肿瘤直径均高于肺腺癌患者(P<0.05),TNM分期和分化程度间未见显著差异(P>0.05)。Ki-67高表达组的SUVmax、MTV、TLG均高于Ki-67低表达组(P<0.05)。经Spearman分析SUVmax、MTV、TLG与Ki-67表达呈正相关(t=0.415、0.422、0.409,P均<0.05)。PD-L1高表达组的SUVmax、MTV、TLG高于PD-L1低表达组,PD-L1低表达组的SUVmax、MTV、TLG高于PD-L1阴性组(P<0.05)。经Spearman分析SUVmax、MTV、TLG与PD-L1表达呈正相关(t=0.421、0.406、0.432,P均<0.05)。结论:NSCLC患者^(18)F-FDG PET/CT参数与癌组织Ki-67、PD-L1的表达呈正相关性,临床上可通过^(18)F-FDG PET/CT参数结果判断Ki-67、PD-L1的表达状态。
Objective:To explore the relationship between fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)parameters and tumor proliferation antigen(Ki-67),programmed death ligand 1(PD-L1)in patients with non-small cell lung cancer(NSCLC).Methods:A total of 72 patients with NSCLC admitted to the hospital were enrolled between September 2021 and April 2024.^(18)F-FDG PET/CT parameters,clinical staging,tumor diameter and differentiation degree in patients with different pathological characteristics were compared.The expressions of Ki-67 and PDL1 were detected by immunohistochemistry.According to Ki-67 expression,patients were divided into high-expression Ki-67group(41 cases,≥50%)and low-expression Ki-67 group(31 cases),<50%,and^(18)F-FDG PET/CT parameters(maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),total lesion glycolysis(TLG))in the two groups were compared.According to PD-L1 expression,patients were divided into negative group(13 cases),low-expression PD-L1 group(27 cases)and high-expression PD-L1 group(32 cases),and^(18)F-FDG PET/CT parameters in three groups were compared.The correlation between^(18)F-FDG PET/CT parameters and Ki-67,PD-L1 was analyzed by Spearman.Results:SUVmax,MTV,TLG and tumor diameter in patients with lung squamous cell carcinoma were higher than those with lung adenocarcinoma(P<0.05),but there was no significant difference in TNM staging and differentiation degree(P>0.05).SUVmax,MTV and TLG in highexpression Ki-67 group were higher than those in low-expression Ki-67 group(P<0.05).Spearman analysis showed that SUVmax,MTV and TLG were positively correlated with Ki-67(t=0.415,0.422,0.409,P<0.05).SUVmax,MTV and TLG were gradually decreased in high-expression PD-L1 group,low-expression PD-L1 group and negative group(P<0.05).Spearman analysis showed that SUVmax,MTV and TLG were positively correlated with PD-L1(t=0.421,0.406,0.432,P<0.05).Conclusion:^(18)F-FDG PET/CT parameters are positively correlated with Ki-67 and PD-L1 in NSCLC patients.Clinically,expression status of Ki-67 and PD-L1 can be determined according to^(18)F-FDG PET/CT parameters.
作者
宋烈晶
徐海青
詹必成
张垒
胡玉华
SONG Lie-jing;XU Hai-qing;ZHAN Bi-cheng;ZHANG Lei;HU Yu-hua(Anqing Municipal Hospital,Anqing Anhui 246003,China)
出处
《中国临床医学影像杂志》
北大核心
2025年第3期179-183,共5页
Journal of China Clinic Medical Imaging
基金
安徽医科大学科研基金资助项目(编号:2020xkj240)。
作者简介
宋烈晶(1982-),男,安徽安庆人,副主任医师。E-mail:aqsonglj@126.com;通信作者:宋烈晶,安庆市立医院核医学科,246003。E-mail:aqsonglj@126.com。
