Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores th...Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores the immunoregulatory role of regulatory T(Treg)cells in ischemic stroke,providing an innovative therapeutic strategy.Neuroinflammation is a major driver of secondary injury after stroke.Existing treatments focus on vascular recanalization while neglecting immune regulation.Their study proposes to modulate neuroinflammation through in vitro-induced Treg cells,offering a novel approach distinct from traditional thrombolysis and endovascular interventions.展开更多
The southeastern edge of the Tibetan plateau is marked by several thrust sheets trending roughly in E\|W direction. The Yanyuan thrust sheet is bounded by three arcuate thrust belts, marked by high mountain ranges wit...The southeastern edge of the Tibetan plateau is marked by several thrust sheets trending roughly in E\|W direction. The Yanyuan thrust sheet is bounded by three arcuate thrust belts, marked by high mountain ranges with the Jinhe belt on the north, the Qianhe belt on the south and the Ninglang belt on the west. Within the Yanyuan thrust belt are sedimentary cover rocks of the Yangtze platform, with ages ranging from Sinian to Triassic. In the north, the thrust sheet is overlain by the Muli thrust sheet along the Jinhe belt, while in the south, it is underlain by the Kangdian paleoland along the Qianhe belt. The youngest rocks on the foot wall are late Eocene to Oligocene in age, indicating that the thrusting occurred in the late Tertiary. The top of the Yanyuan thrust belt is truncated by a flat erosion surface similar to that on the plateau to the north. Along a north\|dipping normal fault bordering the Yanyuan basin on the south, the erosion surface is tilted to the south against Triassic rocks. The basin is filled with coal\|bearing clastic sediments of Pliocene and early Pleistocene age, which gives the timing of the normal faulting. Based on the faulting pattern, we propose that the southeastern edge of the Tibetan plateau underwent a large amount of N\|S shortening and uplift along the Yanyuan thrust sheet in the late Tertiary, while the subsequent normal faulting that had occurred along the Yanyuan basin during the Pliocene and Pliocene can be interpreted to have accommodated gravitational collapse of the crust.展开更多
Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW C...Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW Corporation,Amherst,NY;3.LMU Debusk School of Medicine,Harrogate,TN)Abstract:Using archival peripheral blood slides from radiation accident patients,we have recently described the pseudo-Pelger Huët anomaly(PPHA)in neutrophils as a new radiation-induced biomarker,useful for dosimetry not only immediately after a radiation incident but also potentially helpful as a tool in retrospective dosimetry.展开更多
Cenozoic high\|K igneous rocks are widely distributed in eastern Tibet. These rocks are exposed as flows, dykes and small intrusions along a narrow north\|south trending zone, which follows Tertiary fold belts and the...Cenozoic high\|K igneous rocks are widely distributed in eastern Tibet. These rocks are exposed as flows, dykes and small intrusions along a narrow north\|south trending zone, which follows Tertiary fold belts and the Batang—Lijiang and Ailao Shan—Red River strike\|slip systems. Although several models were proposed to interpret their petrogenesis (Deng, 1989; Arnaud et al., 1991; Turner et al., 1996; Yin et al., 1995; Miller et al., 1999), their origin still remains hotly debated. Moreover, the published results were only focused on the high\|K igneous rocks resulted from partial melting of an enriched lithospheric mantle. Here, we present the detailed documents to testify the existence of a new kind of high\|K igneous rocks in eastern Tibet.Our new 39 Ar/ 40 Ar age data (Wang et al., 1999) and published age data for high\|K rocks in eastern Tibet show two distinctive magmatic episodes: one between 42Ma and 24Ma, and the other since ca.16Ma. They correspond to two types of high\|K magmatism in eastern Tibet. We name the older and younger groups as types Ⅰ and Ⅱ, respectively.展开更多
The accuracy of present flatness predictive method is limited and it just belongs to software simulation. In order to improve it, a novel flatness predictive model via T-S cloud reasoning network implemented by digita...The accuracy of present flatness predictive method is limited and it just belongs to software simulation. In order to improve it, a novel flatness predictive model via T-S cloud reasoning network implemented by digital signal processor(DSP) is proposed. First, the combination of genetic algorithm(GA) and simulated annealing algorithm(SAA) is put forward, called GA-SA algorithm, which can make full use of the global search ability of GA and local search ability of SA. Later, based on T-S cloud reasoning neural network, flatness predictive model is designed in DSP. And it is applied to 900 HC reversible cold rolling mill. Experimental results demonstrate that the flatness predictive model via T-S cloud reasoning network can run on the hardware DSP TMS320 F2812 with high accuracy and robustness by using GA-SA algorithm to optimize the model parameter.展开更多
Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer...Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer.Methods We retrospectively reviewed the records of 394 consecutive patients with pathologically confirmed breast lesions who had undergone 3-T magnetic resonance imaging(MRI).The morphological characteristics of breast lesions were evaluated using DCE,DWI,and T2WI based on BI-RADS lexicon descriptors by trained radiologists.Patients were categorized into mass and non-mass groups based on MRI characteristics of the lesions,and the differences between benign and malignant lesions in each group were compared.Clinical prediction models for breast cancer diagnosis were constructed using logistic regression analysis.Diagnostic efficacies were compared using the area under the receiver operating characteristic curve(AUC)and DeLong test.Results For mass-like lesions,all the morphological parameters significantly differentiated benign and malignant lesions on consensus DCE,DWI,and T2WI(P<0.05).The combined method(DCE+DWI+T2WI)had a higher AUC(0.865)than any of the individual modality(DCE:0.786;DWI:0.793;T2WI:0.809)(P<0.05).For non-mass-like lesions,DWI signal intensity was a significant predictor of malignancy(P=0.036),but the model using DWI alone had a low AUC(0.669).Conclusion Morphological assessment using the combination of DCE,DWI,and T2WI provides better diagnostic value in differentiating benign and malignant breast mass-like lesions than assessment with only one of the modalities.展开更多
he convergence between India and Eurasia is partly accommodated by motion of a few large blocks along strike\|slip faults. About 1800km long Altyn Tagh fault strikes in N60～80°E and allows the northeastward disp...he convergence between India and Eurasia is partly accommodated by motion of a few large blocks along strike\|slip faults. About 1800km long Altyn Tagh fault strikes in N60～80°E and allows the northeastward displacement of the Tibet plateau relative to the Tarim. The Altyn Tagh fault zone is a typical transpressional fault zone, characterized by blocks rotation and crustal shortening and vertical extrusion of blocks within the Altyn Tagh strike\|slip system. Differences of three\|dimensional deformation and configuration of the active structures are recognized at different segment of the Altyn Tagh fault zone.1\ Structural configuration of the Altyn Tagh fault zone\;In the Altyn Tagh strike\|slip fault zone, the assemblage pattern of the (active) faults is in the form of parallel plumes, especially in the eastern and the western segments of the Altyn Tagh fault zone. These plumes structures in the eastern segment are assembled by string\|like left lateral strike\|slip fault and broom\|like thrusting faults, and in the western segment by arc\|like left lateral strike\|slip faults along with thrusting faults and normal faults. In the middle segment of the Altyn Tagh fault zone, the structures are characterized by the string\|like left lateral strike\|slip faults in the center and reverse thrusting faults on the two sides.展开更多
Austenitic stainless steel(ASS) and High nickel steel(HNS) welding consumables are being used for welding Q&T steels, as they have higher solubility for hydrogen in austenitic phase, to avoid hydrogen induced crac...Austenitic stainless steel(ASS) and High nickel steel(HNS) welding consumables are being used for welding Q&T steels, as they have higher solubility for hydrogen in austenitic phase, to avoid hydrogen induced cracking(HIC) but they are very expensive. In recent years, the developments of low hydrogen ferritic steel(LHF) consumables that contain no hygroscopic compounds are utilized for welding Q&T steels. Heat affected zone(HAZ) softening is another critical issue during welding of armour grade Q&T steels and it depends on the welding process employed and the weld thermal cycle. In this investigation an attempt has been made to study the influence of welding consumables and welding processes on metallurgical characteristics of armour grade Q&T steel joints by various metallurgical characterization procedures. Shielded metal arc welding(SMAW) and flux cored arc welding(FCAW) processes were used for making welds using ASS, LHF and HNS welding consumables. The joints fabricated by using LHF consumables offered lower degree of HAZ softening and there is no evidence of HIC in the joints fabricated using LHF consumables.展开更多
The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided in...The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided into four terranes (from north to south): Songpan\|Garze, Qingtang, Lhasa and India terranes. The Qiangtang terrane was divided into two parts by Chabu\|Shuanghu suture: Northern Qiangtang and Southern Qiangtang blocks. It was believed that there is a suture as Palaeotethyan suture between the two blocks from Lungmu lake to Chabu, to Shuanghu, to Langcangjiang, but some geologists opposited this opinion, such as Wang Chengshan et al.(1987) and Deng Wanming et al.(1996). The blueschists that bear the typical glaucophane were found in the Gangmar Area in summer of 1997. The blueschists consist of glaucophane, crossite, phengite, actinolite, epidote, sphene ,rutile, and so on. Blueschists show nappe structures in enclosing rocks, and thrust over Tertiary from north to south.The age of blueschist is 275～285Ma which stand for the metamorphic age of blueschist. The geochemical contents of blueschists are the following: SiO\-2 is 45 37%～53 82%, Na 2O>K 2O, K 2O+Na 2O are 3 72%～7 61%, Na 2O/K 2O is 1 70～19 67, MnO is 0 16%～0 22%, FeO+Fe 2O 3 are 11 12%～14 27%, TiO 2 is 2 34%～4 28%, P 2O 5 is 0 34%～1 03%. From the contents, SiO 2 is inverse relation with K 2O+Na 2O, K 2O and FeO+Fe 2O 3. In the SiO 2\|K 2O+Na 2O diagram, the blueschists fall in the field of Alkali basalt; in the TiO 2\|MnO(10\|P 2O 5×10 triangular diagram, these plot within the Ocean Island Basalts(OIB) field. The whole REE content is (117 03～390 97)×10 -6 , LREE/HREE is 5 05～9 80, the REE diagram shows the feature that LREE is rich and HREE is depleted, this is similar to the OIB. In the spidergram of trace elements show the same characterristics as the OIB. Meanwhile, the trace elements ratios, such as Ba/Nb, La/Nb, Nb/Th, Nb/Y, Zr/Y, Zr/Nb, Hf/Sm, Ta/Hf, Nb/Ta, Nb/U, suggest the tectonic setting is OIB. On the basis of these materials, the blueschists are akin to within\|plate ocean island basalts. This shows that there is a ocean or oceanic basin in the Chabu\|Shuanghu belts and the formation of blueschists is the quicky subduction of the Ocean Island Basalts in Early Permian between the Gondwana and Eurasia continents. It demonstrated, therefore, that the Chabu\|Suanghu suture exists and may extend to the east to Lnagchangjiang, and may extend into Thailand\|Malaysia Peninsula.展开更多
A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly forme...A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly formed to represent the nonlinear system of PMSM. For converting the tracking control into a stabilization problem, a new control design was proposed to define the internal desired states. Then, the FSMC controller for PMSM system with parameter variation and load disturbance was designed based on the fuzzy model. The performance of the proposed controller was verified by experimental results on PMSM system. The results show that the FSMC scheme can drive the dynamics of PMSM into a designated sliding surface in finite time and guarantee the property of asymptotical stability. The information of upper bound of modeling errors as well as perturbations is not required when using the FSMC controller.展开更多
基于福建省冬半年沿海和港湾岛屿自动站的逐时极大风观测资料和WRF（Weather Research and Forecast）、EC（European Centre for Medium-Range Weather Forecasts）细网格以及T639（TL639L60）三种模式预报的10 m风场资料，将模式预报...基于福建省冬半年沿海和港湾岛屿自动站的逐时极大风观测资料和WRF（Weather Research and Forecast）、EC（European Centre for Medium-Range Weather Forecasts）细网格以及T639（TL639L60）三种模式预报的10 m风场资料，将模式预报的风向风速与观测资料进行对比检验，结果表明：福建省沿海冬半年大风的盛行风向以东北风为主，大风的时空分布极为不均，沿海风力的脉动性、跳跃性、局地性突出。从三种模式对风速风向的模拟效果来看， WRF和EC细网格的预报效果较好，有可参考性， T639可参考性不高。对于风速，模式预报结果相比实况极大风速偏小，港湾岛屿代表站风速的平均绝对误差均小于沿海代表站，预报平均误差由沿海向内陆逐渐减小，由中部向南北逐渐减小。风向相比风速的预报效果要差， WRF和EC细网格的风向预报误差在45°-50°，有一定的参考意义；港湾岛屿代表站风向的平均绝对误差大于沿海代表站，以浮标站的误差最大。当观测风速出现7级及以上风速时，若对大风进行分级检验，则较低风速的预报平均绝对误差小于较高风速；风向预报的平均绝对误差也大大降低，且误差都在45°以内，具有良好的参考性。展开更多
Hepatocellular carcinoma(HCC),which is essentially primary liver cancer,is closely related to CD8^(+)T cell immune infiltration and immune suppression.We constructed a CD8^(+)T cells related risk score model to predic...Hepatocellular carcinoma(HCC),which is essentially primary liver cancer,is closely related to CD8^(+)T cell immune infiltration and immune suppression.We constructed a CD8^(+)T cells related risk score model to predict the prognosis of HCC patients and provided therapeutic guidance based on the risk score.Using integrated bulk RNA sequencing(RNA-seq)and single-cell RNA sequencing(scRNA-seq)datasets,we identified stable CD8^(+)T cell signatures.Based on these signatures,a 3-gene risk score model,comprised of KLRB1,RGS 2,and TNFRSF1B was constructed.The risk score model was well validated through an independent external validation cohort.We divided patients into high-risk and low-risk groups according to the risk score and compared the differences in immune microenvironment between these two groups.Compared with low-risk patients,high-risk patients have higher M2-type macrophage content(P<0.0001)and lower CD8^(+)T cells infiltration(P<0.0001).High-risk patients predict worse response to immunotherapy treatment than low-risk patients(P<0.01).Drug sensitivity analysis shows that PI3K-β inhibitor AZD6482 and TGFβRII inhibitor SB505124 may be suitable therapies for high-risk patients,while the IGF-1R inhibitor BMS-754807 or the novel pyrimidine-based anti-tumor metabolic drug Gemcitabine could be potential therapeutic choices for low-risk patients.Moreover,expression of these 3-gene model was verified by immunohistochemistry.In summary,the establishment and validation of a CD8^(+)T cell-derived risk model can more accurately predict the prognosis of HCC patients and guide the construction of personalized treatment plans.展开更多
文摘Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores the immunoregulatory role of regulatory T(Treg)cells in ischemic stroke,providing an innovative therapeutic strategy.Neuroinflammation is a major driver of secondary injury after stroke.Existing treatments focus on vascular recanalization while neglecting immune regulation.Their study proposes to modulate neuroinflammation through in vitro-induced Treg cells,offering a novel approach distinct from traditional thrombolysis and endovascular interventions.
文摘The southeastern edge of the Tibetan plateau is marked by several thrust sheets trending roughly in E\|W direction. The Yanyuan thrust sheet is bounded by three arcuate thrust belts, marked by high mountain ranges with the Jinhe belt on the north, the Qianhe belt on the south and the Ninglang belt on the west. Within the Yanyuan thrust belt are sedimentary cover rocks of the Yangtze platform, with ages ranging from Sinian to Triassic. In the north, the thrust sheet is overlain by the Muli thrust sheet along the Jinhe belt, while in the south, it is underlain by the Kangdian paleoland along the Qianhe belt. The youngest rocks on the foot wall are late Eocene to Oligocene in age, indicating that the thrusting occurred in the late Tertiary. The top of the Yanyuan thrust belt is truncated by a flat erosion surface similar to that on the plateau to the north. Along a north\|dipping normal fault bordering the Yanyuan basin on the south, the erosion surface is tilted to the south against Triassic rocks. The basin is filled with coal\|bearing clastic sediments of Pliocene and early Pleistocene age, which gives the timing of the normal faulting. Based on the faulting pattern, we propose that the southeastern edge of the Tibetan plateau underwent a large amount of N\|S shortening and uplift along the Yanyuan thrust sheet in the late Tertiary, while the subsequent normal faulting that had occurred along the Yanyuan basin during the Pliocene and Pliocene can be interpreted to have accommodated gravitational collapse of the crust.
文摘Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW Corporation,Amherst,NY;3.LMU Debusk School of Medicine,Harrogate,TN)Abstract:Using archival peripheral blood slides from radiation accident patients,we have recently described the pseudo-Pelger Huët anomaly(PPHA)in neutrophils as a new radiation-induced biomarker,useful for dosimetry not only immediately after a radiation incident but also potentially helpful as a tool in retrospective dosimetry.
文摘Cenozoic high\|K igneous rocks are widely distributed in eastern Tibet. These rocks are exposed as flows, dykes and small intrusions along a narrow north\|south trending zone, which follows Tertiary fold belts and the Batang—Lijiang and Ailao Shan—Red River strike\|slip systems. Although several models were proposed to interpret their petrogenesis (Deng, 1989; Arnaud et al., 1991; Turner et al., 1996; Yin et al., 1995; Miller et al., 1999), their origin still remains hotly debated. Moreover, the published results were only focused on the high\|K igneous rocks resulted from partial melting of an enriched lithospheric mantle. Here, we present the detailed documents to testify the existence of a new kind of high\|K igneous rocks in eastern Tibet.Our new 39 Ar/ 40 Ar age data (Wang et al., 1999) and published age data for high\|K rocks in eastern Tibet show two distinctive magmatic episodes: one between 42Ma and 24Ma, and the other since ca.16Ma. They correspond to two types of high\|K magmatism in eastern Tibet. We name the older and younger groups as types Ⅰ and Ⅱ, respectively.
基金Project(E2015203354)supported by Natural Science Foundation of Steel United Research Fund of Hebei Province,ChinaProject(ZD2016100)supported by the Science and the Technology Research Key Project of High School of Hebei Province,China+1 种基金Project(LJRC013)supported by the University Innovation Team of Hebei Province Leading Talent Cultivation,ChinaProject(16LGY015)supported by the Basic Research Special Breeding of Yanshan University,China
文摘The accuracy of present flatness predictive method is limited and it just belongs to software simulation. In order to improve it, a novel flatness predictive model via T-S cloud reasoning network implemented by digital signal processor(DSP) is proposed. First, the combination of genetic algorithm(GA) and simulated annealing algorithm(SAA) is put forward, called GA-SA algorithm, which can make full use of the global search ability of GA and local search ability of SA. Later, based on T-S cloud reasoning neural network, flatness predictive model is designed in DSP. And it is applied to 900 HC reversible cold rolling mill. Experimental results demonstrate that the flatness predictive model via T-S cloud reasoning network can run on the hardware DSP TMS320 F2812 with high accuracy and robustness by using GA-SA algorithm to optimize the model parameter.
文摘Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer.Methods We retrospectively reviewed the records of 394 consecutive patients with pathologically confirmed breast lesions who had undergone 3-T magnetic resonance imaging(MRI).The morphological characteristics of breast lesions were evaluated using DCE,DWI,and T2WI based on BI-RADS lexicon descriptors by trained radiologists.Patients were categorized into mass and non-mass groups based on MRI characteristics of the lesions,and the differences between benign and malignant lesions in each group were compared.Clinical prediction models for breast cancer diagnosis were constructed using logistic regression analysis.Diagnostic efficacies were compared using the area under the receiver operating characteristic curve(AUC)and DeLong test.Results For mass-like lesions,all the morphological parameters significantly differentiated benign and malignant lesions on consensus DCE,DWI,and T2WI(P<0.05).The combined method(DCE+DWI+T2WI)had a higher AUC(0.865)than any of the individual modality(DCE:0.786;DWI:0.793;T2WI:0.809)(P<0.05).For non-mass-like lesions,DWI signal intensity was a significant predictor of malignancy(P=0.036),but the model using DWI alone had a low AUC(0.669).Conclusion Morphological assessment using the combination of DCE,DWI,and T2WI provides better diagnostic value in differentiating benign and malignant breast mass-like lesions than assessment with only one of the modalities.
文摘he convergence between India and Eurasia is partly accommodated by motion of a few large blocks along strike\|slip faults. About 1800km long Altyn Tagh fault strikes in N60～80°E and allows the northeastward displacement of the Tibet plateau relative to the Tarim. The Altyn Tagh fault zone is a typical transpressional fault zone, characterized by blocks rotation and crustal shortening and vertical extrusion of blocks within the Altyn Tagh strike\|slip system. Differences of three\|dimensional deformation and configuration of the active structures are recognized at different segment of the Altyn Tagh fault zone.1\ Structural configuration of the Altyn Tagh fault zone\;In the Altyn Tagh strike\|slip fault zone, the assemblage pattern of the (active) faults is in the form of parallel plumes, especially in the eastern and the western segments of the Altyn Tagh fault zone. These plumes structures in the eastern segment are assembled by string\|like left lateral strike\|slip fault and broom\|like thrusting faults, and in the western segment by arc\|like left lateral strike\|slip faults along with thrusting faults and normal faults. In the middle segment of the Altyn Tagh fault zone, the structures are characterized by the string\|like left lateral strike\|slip faults in the center and reverse thrusting faults on the two sides.
基金Armament Research Board (ARMREB), New Delhi for funding this project work (Project no. MAA/03/ 41)
文摘Austenitic stainless steel(ASS) and High nickel steel(HNS) welding consumables are being used for welding Q&T steels, as they have higher solubility for hydrogen in austenitic phase, to avoid hydrogen induced cracking(HIC) but they are very expensive. In recent years, the developments of low hydrogen ferritic steel(LHF) consumables that contain no hygroscopic compounds are utilized for welding Q&T steels. Heat affected zone(HAZ) softening is another critical issue during welding of armour grade Q&T steels and it depends on the welding process employed and the weld thermal cycle. In this investigation an attempt has been made to study the influence of welding consumables and welding processes on metallurgical characteristics of armour grade Q&T steel joints by various metallurgical characterization procedures. Shielded metal arc welding(SMAW) and flux cored arc welding(FCAW) processes were used for making welds using ASS, LHF and HNS welding consumables. The joints fabricated by using LHF consumables offered lower degree of HAZ softening and there is no evidence of HIC in the joints fabricated using LHF consumables.
文摘The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided into four terranes (from north to south): Songpan\|Garze, Qingtang, Lhasa and India terranes. The Qiangtang terrane was divided into two parts by Chabu\|Shuanghu suture: Northern Qiangtang and Southern Qiangtang blocks. It was believed that there is a suture as Palaeotethyan suture between the two blocks from Lungmu lake to Chabu, to Shuanghu, to Langcangjiang, but some geologists opposited this opinion, such as Wang Chengshan et al.(1987) and Deng Wanming et al.(1996). The blueschists that bear the typical glaucophane were found in the Gangmar Area in summer of 1997. The blueschists consist of glaucophane, crossite, phengite, actinolite, epidote, sphene ,rutile, and so on. Blueschists show nappe structures in enclosing rocks, and thrust over Tertiary from north to south.The age of blueschist is 275～285Ma which stand for the metamorphic age of blueschist. The geochemical contents of blueschists are the following: SiO\-2 is 45 37%～53 82%, Na 2O>K 2O, K 2O+Na 2O are 3 72%～7 61%, Na 2O/K 2O is 1 70～19 67, MnO is 0 16%～0 22%, FeO+Fe 2O 3 are 11 12%～14 27%, TiO 2 is 2 34%～4 28%, P 2O 5 is 0 34%～1 03%. From the contents, SiO 2 is inverse relation with K 2O+Na 2O, K 2O and FeO+Fe 2O 3. In the SiO 2\|K 2O+Na 2O diagram, the blueschists fall in the field of Alkali basalt; in the TiO 2\|MnO(10\|P 2O 5×10 triangular diagram, these plot within the Ocean Island Basalts(OIB) field. The whole REE content is (117 03～390 97)×10 -6 , LREE/HREE is 5 05～9 80, the REE diagram shows the feature that LREE is rich and HREE is depleted, this is similar to the OIB. In the spidergram of trace elements show the same characterristics as the OIB. Meanwhile, the trace elements ratios, such as Ba/Nb, La/Nb, Nb/Th, Nb/Y, Zr/Y, Zr/Nb, Hf/Sm, Ta/Hf, Nb/Ta, Nb/U, suggest the tectonic setting is OIB. On the basis of these materials, the blueschists are akin to within\|plate ocean island basalts. This shows that there is a ocean or oceanic basin in the Chabu\|Shuanghu belts and the formation of blueschists is the quicky subduction of the Ocean Island Basalts in Early Permian between the Gondwana and Eurasia continents. It demonstrated, therefore, that the Chabu\|Suanghu suture exists and may extend to the east to Lnagchangjiang, and may extend into Thailand\|Malaysia Peninsula.
基金Project (60835004) supported by the National Natural Science Foundation of China
文摘A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly formed to represent the nonlinear system of PMSM. For converting the tracking control into a stabilization problem, a new control design was proposed to define the internal desired states. Then, the FSMC controller for PMSM system with parameter variation and load disturbance was designed based on the fuzzy model. The performance of the proposed controller was verified by experimental results on PMSM system. The results show that the FSMC scheme can drive the dynamics of PMSM into a designated sliding surface in finite time and guarantee the property of asymptotical stability. The information of upper bound of modeling errors as well as perturbations is not required when using the FSMC controller.
文摘基于福建省冬半年沿海和港湾岛屿自动站的逐时极大风观测资料和WRF（Weather Research and Forecast）、EC（European Centre for Medium-Range Weather Forecasts）细网格以及T639（TL639L60）三种模式预报的10 m风场资料，将模式预报的风向风速与观测资料进行对比检验，结果表明：福建省沿海冬半年大风的盛行风向以东北风为主，大风的时空分布极为不均，沿海风力的脉动性、跳跃性、局地性突出。从三种模式对风速风向的模拟效果来看， WRF和EC细网格的预报效果较好，有可参考性， T639可参考性不高。对于风速，模式预报结果相比实况极大风速偏小，港湾岛屿代表站风速的平均绝对误差均小于沿海代表站，预报平均误差由沿海向内陆逐渐减小，由中部向南北逐渐减小。风向相比风速的预报效果要差， WRF和EC细网格的风向预报误差在45°-50°，有一定的参考意义；港湾岛屿代表站风向的平均绝对误差大于沿海代表站，以浮标站的误差最大。当观测风速出现7级及以上风速时，若对大风进行分级检验，则较低风速的预报平均绝对误差小于较高风速；风向预报的平均绝对误差也大大降低，且误差都在45°以内，具有良好的参考性。
基金国家自然科学基金项目(No.81902513)山西省应用基础研究计划项目(No.202303021211114 and 202103021224228)山西省高等教育百亿工程“科技引导”专项(No.BYJL047)资助。
文摘Hepatocellular carcinoma(HCC),which is essentially primary liver cancer,is closely related to CD8^(+)T cell immune infiltration and immune suppression.We constructed a CD8^(+)T cells related risk score model to predict the prognosis of HCC patients and provided therapeutic guidance based on the risk score.Using integrated bulk RNA sequencing(RNA-seq)and single-cell RNA sequencing(scRNA-seq)datasets,we identified stable CD8^(+)T cell signatures.Based on these signatures,a 3-gene risk score model,comprised of KLRB1,RGS 2,and TNFRSF1B was constructed.The risk score model was well validated through an independent external validation cohort.We divided patients into high-risk and low-risk groups according to the risk score and compared the differences in immune microenvironment between these two groups.Compared with low-risk patients,high-risk patients have higher M2-type macrophage content(P<0.0001)and lower CD8^(+)T cells infiltration(P<0.0001).High-risk patients predict worse response to immunotherapy treatment than low-risk patients(P<0.01).Drug sensitivity analysis shows that PI3K-β inhibitor AZD6482 and TGFβRII inhibitor SB505124 may be suitable therapies for high-risk patients,while the IGF-1R inhibitor BMS-754807 or the novel pyrimidine-based anti-tumor metabolic drug Gemcitabine could be potential therapeutic choices for low-risk patients.Moreover,expression of these 3-gene model was verified by immunohistochemistry.In summary,the establishment and validation of a CD8^(+)T cell-derived risk model can more accurately predict the prognosis of HCC patients and guide the construction of personalized treatment plans.
