Autosomal dominant polycystic kidney disease(ADPKD)is one of the most common human hereditary disorder characteristic of development of bilateral multiple fluid-filled kidney cysts.Accumulated evidence has suggested t...Autosomal dominant polycystic kidney disease(ADPKD)is one of the most common human hereditary disorder characteristic of development of bilateral multiple fluid-filled kidney cysts.Accumulated evidence has suggested that primary cilium of renal epithelial cell plays a key role in cystogenesis.In this article we will give an overview on the basic information about polycystic kidney disease(PKD)and summarize the recent progresses in studies of regulation of polycystin-1 and-2 trafficking to cilia.We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD.展开更多
Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately caus...Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-展开更多
子宫内膜异位症(endometriosis,EMs)是全球女性健康面临的常见挑战。近年来,铁死亡作为一种新兴的细胞程序性死亡方式,在EMs研究中备受瞩目。在疾病机制方面,铁死亡通过铁过载诱导,推动卵巢EMs的纤维化,同时通过调控多条信号通路如p38...子宫内膜异位症(endometriosis,EMs)是全球女性健康面临的常见挑战。近年来,铁死亡作为一种新兴的细胞程序性死亡方式,在EMs研究中备受瞩目。在疾病机制方面,铁死亡通过铁过载诱导,推动卵巢EMs的纤维化,同时通过调控多条信号通路如p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38 MAPK)/信号转导子和转录激活子6(signal transducer and activator of transcription 6,STAT6),促进血管生成、自噬等,加剧病情进展。在不孕问题上,铁死亡影响胚胎发育和卵巢功能,显著降低生育能力。诊断方面,铁死亡相关基因高表达为EMs的早期诊断提供了潜在的标志物,有效区分患者和健康个体,具有重要的临床应用价值。治疗策略上,Erastin等非天然化合物及白藜芦醇、熊果酸和汉黄芩素等天然化合物,展现出潜在的治疗效果,可缓解EMs的病理进程和相关症状。因此,本文通过综述铁死亡在EMs发病机制、不孕问题、诊断和治疗中的多重作用,全面阐述了铁死亡在子宫内膜异位症中的关键作用,探索其作为诊断标志物和治疗靶点的潜力,为EMs的管理提供新的理论支持和治疗策略。展开更多
文摘Autosomal dominant polycystic kidney disease(ADPKD)is one of the most common human hereditary disorder characteristic of development of bilateral multiple fluid-filled kidney cysts.Accumulated evidence has suggested that primary cilium of renal epithelial cell plays a key role in cystogenesis.In this article we will give an overview on the basic information about polycystic kidney disease(PKD)and summarize the recent progresses in studies of regulation of polycystin-1 and-2 trafficking to cilia.We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD.
基金supported by National Natural Science Foundation of China(Grant No. 11172340)Training Program for Hundreds of Distinguished Leading Scientists of Chongqing+3 种基金Chongqing Natural Science Foundation(Grant No.CSTC2010BA5001,CSTC2012jjA0588)Fundamental Research Funds for the Central Universities(Grant No.CQDXWL-2012-123)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120191120032)Sharing Fund of Chongqing University's LargeScale Equipment(Grant No.2010063057,2011063048,2011063049)
文摘Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-
文摘子宫内膜异位症(endometriosis,EMs)是全球女性健康面临的常见挑战。近年来,铁死亡作为一种新兴的细胞程序性死亡方式,在EMs研究中备受瞩目。在疾病机制方面,铁死亡通过铁过载诱导,推动卵巢EMs的纤维化,同时通过调控多条信号通路如p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38 MAPK)/信号转导子和转录激活子6(signal transducer and activator of transcription 6,STAT6),促进血管生成、自噬等,加剧病情进展。在不孕问题上,铁死亡影响胚胎发育和卵巢功能,显著降低生育能力。诊断方面,铁死亡相关基因高表达为EMs的早期诊断提供了潜在的标志物,有效区分患者和健康个体,具有重要的临床应用价值。治疗策略上,Erastin等非天然化合物及白藜芦醇、熊果酸和汉黄芩素等天然化合物,展现出潜在的治疗效果,可缓解EMs的病理进程和相关症状。因此,本文通过综述铁死亡在EMs发病机制、不孕问题、诊断和治疗中的多重作用,全面阐述了铁死亡在子宫内膜异位症中的关键作用,探索其作为诊断标志物和治疗靶点的潜力,为EMs的管理提供新的理论支持和治疗策略。
