Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
The construction of control Lyapunov functions for a class of nonlinear systems is considered. We develop a method by which a control Lyapunov function for the feedback linearizable part can be constructed systematica...The construction of control Lyapunov functions for a class of nonlinear systems is considered. We develop a method by which a control Lyapunov function for the feedback linearizable part can be constructed systematically via Lyapunov equation. Moreover, by a control Lyapunov function of the feedback linearizable part and a Lyapunov function of the zero dynamics, a control Lyapunov function for the overall nonlinear system is established.展开更多
For discrete-time T-S fuzzy systems, the stability and controller design method are in-vestigated based on parameter-dependent Lyapunov function (PDLF). T-S fuzzy systems di?er fromnon-fuzzy systems with polytopic des...For discrete-time T-S fuzzy systems, the stability and controller design method are in-vestigated based on parameter-dependent Lyapunov function (PDLF). T-S fuzzy systems di?er fromnon-fuzzy systems with polytopic description or multi-model description in that the weighting coef-ficients have respective meanings. They, however, have stability aspect in common. By adopting astability condition for polytopic systems obtained via PDLF, and combining the properties of T-Sfuzzy systems, new results are given in this paper. An example shows that by applying the newresults, the stability conditions that can be distinguished are less conservative.展开更多
A method is developed by which control Lyapunov functions of a class of nonlinear systems can be constructed systematically. Based on the control Lyapunov function, a feedback control is obtained to stabilize the clos...A method is developed by which control Lyapunov functions of a class of nonlinear systems can be constructed systematically. Based on the control Lyapunov function, a feedback control is obtained to stabilize the closed-loop system. In addition, this method is applied to stabilize the Benchmark system. A simulation shows the effectiveness of the method.展开更多
The stabilization of discrete nonlinear systems is studied. Based on control Lyapunov functions, a sufficient and necessary condition for a quadratic function to be a control Lyapunov function is given. From this cond...The stabilization of discrete nonlinear systems is studied. Based on control Lyapunov functions, a sufficient and necessary condition for a quadratic function to be a control Lyapunov function is given. From this condition, a continuous state feedback law is constructed explicitly. It can globally asymptotically stabilize the equilibrium of the closed-loop system. A simulation example shows the effectiveness of the proposed method.展开更多
The problem of adaptive stabilization of a class of multi-input nonlinear systems with unknown parameters both in the state vector-field and the input vector-field has been considered. By employing the control Lyapuno...The problem of adaptive stabilization of a class of multi-input nonlinear systems with unknown parameters both in the state vector-field and the input vector-field has been considered. By employing the control Lyapunov function method, a direct adaptive controller is designed to complete the global adaptive stability of the uncertain system. At the same time, the controller is also verified to possess the optimality. Example and simulations are provided to illustrate the effectiveness of the proposed method.展开更多
目的探讨针刺联合重复经颅磁刺激疗法(transcranial magnetic stimulation,TMS)对帕金森患者认知功能的改善效果。方法选择2021年5月—2023年4月于丽水市中医院就诊的87例帕金森患者,依照随机数字表法将其分为A组(43例)与B组(44例)。A...目的探讨针刺联合重复经颅磁刺激疗法(transcranial magnetic stimulation,TMS)对帕金森患者认知功能的改善效果。方法选择2021年5月—2023年4月于丽水市中医院就诊的87例帕金森患者,依照随机数字表法将其分为A组(43例)与B组(44例)。A组给予TMS治疗,B组在此基础上联合针刺治疗。两组均治疗8周,比较两组临床疗效、治疗前及治疗8周后P300潜伏期、波幅、血清脑神经递质5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺(norepinephrine,NE)、神经营养因子-3(neurotrophic factor-3,NT-3)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、过氧化氢酶(catalase,CAT)、丙二醛(malondialdehyde,MDA)、谷胱甘肽(glutathione,GSH-px)、髓过氧化物酶(myeloperoxidase,MPO)、简易智力状态评分量表(mini-mental state rating scale,MMSE)评分、统一帕金森病评定量表(unified Parkinson′s disease rating scale,UPDRS)评分、中医证候积分。结果与A组比较,B组临床总有效率更高;与治疗前比较,治疗8周后两组P300潜伏期均缩短,B组短于A组;与治疗前比较,治疗8周后两组波幅、MMSE、UPDRS评分、5-HT、NE、NT-3、IGF-1、CAT、MDA水平均增高,B组高于A组;与治疗前比较,治疗8周后两组中医证候积分、GSH-px、MPO水平均下降,B组低于A组;差异有统计学意义(P<0.05)。结论针刺联合TMS用于帕金森治疗可有效提升临床疗效,缓解相关症状,修复神经损伤,改善认知功能,且可降低氧化应激反应。展开更多
The problem of robust L 1 filtering with pole constraint in a disk for linear continuous polytopic uncertain systems is discussed. The attention is focused on design a linear asymptotically stable filter such that th...The problem of robust L 1 filtering with pole constraint in a disk for linear continuous polytopic uncertain systems is discussed. The attention is focused on design a linear asymptotically stable filter such that the filtering error system remains robustly stable, and has a L 1 performance constraint and pole constraint in a disk. The new robust L 1 performance criteria and regional pole placement condition are obtained via parameter-dependent Lyapunov functions method. Upon the proposed multiobjective performance criteria and by means of LMI technique, both full-order and reduced-order robust L 1 filter with suitable dynamic behavior can be obtained from the solution of convex optimization problems. Compared with earlier result in the quadratic framework, this approach turns out to be less conservative. The efficiency of the proposed technique is demonstrated by a numerical example.展开更多
The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain syst...The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain systems are developed with the benefit of the scalar multi-convex function. To be convenient for applications, such conditions are simplified into new linear matrix inequality （LMI） conditions, which can be solved by the powerful LMI toolbox. Numerical examples are provided to indicate that this new approach is less conservative than previous results for Hurwitz stability, Schur stability and D-stability of uncertain systems under certain circumstances.展开更多
A design method for controllers and a comprehensive stability analysis for an acrobat based on Lyapunov functions are presented. Three control laws based on three Lyapunov functions are designed to increase the energy...A design method for controllers and a comprehensive stability analysis for an acrobat based on Lyapunov functions are presented. Three control laws based on three Lyapunov functions are designed to increase the energy so as to move the acrobot into the unstable inverted equilibrium position, and solve the problem of posture and energy. The concept of a non-smooth Lyapunov function is employed to analyze the stability of the whole system. The validity of this strategy is demonstrated by simulations.展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
基金Supported by Natural Science Foundation of Zhejiang Province P. R. China (Y105141)Natural Science Foundation of Fujian Province P.R.China (A0510025)Technological Project of Zhejiang Education Department,P. R. China(20050291)
文摘The construction of control Lyapunov functions for a class of nonlinear systems is considered. We develop a method by which a control Lyapunov function for the feedback linearizable part can be constructed systematically via Lyapunov equation. Moreover, by a control Lyapunov function of the feedback linearizable part and a Lyapunov function of the zero dynamics, a control Lyapunov function for the overall nonlinear system is established.
文摘For discrete-time T-S fuzzy systems, the stability and controller design method are in-vestigated based on parameter-dependent Lyapunov function (PDLF). T-S fuzzy systems di?er fromnon-fuzzy systems with polytopic description or multi-model description in that the weighting coef-ficients have respective meanings. They, however, have stability aspect in common. By adopting astability condition for polytopic systems obtained via PDLF, and combining the properties of T-Sfuzzy systems, new results are given in this paper. An example shows that by applying the newresults, the stability conditions that can be distinguished are less conservative.
基金the Natural Science Foundation of Zhejiang Province,China (Y105141)Technological Project of Zhejiang Education Department,China (20050291).
文摘A method is developed by which control Lyapunov functions of a class of nonlinear systems can be constructed systematically. Based on the control Lyapunov function, a feedback control is obtained to stabilize the closed-loop system. In addition, this method is applied to stabilize the Benchmark system. A simulation shows the effectiveness of the method.
基金the Natural Science Foundation of China (60774011)the Natural ScienceFoundation of Zhejiang Province in China (Y105141)
文摘The stabilization of discrete nonlinear systems is studied. Based on control Lyapunov functions, a sufficient and necessary condition for a quadratic function to be a control Lyapunov function is given. From this condition, a continuous state feedback law is constructed explicitly. It can globally asymptotically stabilize the equilibrium of the closed-loop system. A simulation example shows the effectiveness of the proposed method.
文摘The problem of adaptive stabilization of a class of multi-input nonlinear systems with unknown parameters both in the state vector-field and the input vector-field has been considered. By employing the control Lyapunov function method, a direct adaptive controller is designed to complete the global adaptive stability of the uncertain system. At the same time, the controller is also verified to possess the optimality. Example and simulations are provided to illustrate the effectiveness of the proposed method.
文摘The problem of robust L 1 filtering with pole constraint in a disk for linear continuous polytopic uncertain systems is discussed. The attention is focused on design a linear asymptotically stable filter such that the filtering error system remains robustly stable, and has a L 1 performance constraint and pole constraint in a disk. The new robust L 1 performance criteria and regional pole placement condition are obtained via parameter-dependent Lyapunov functions method. Upon the proposed multiobjective performance criteria and by means of LMI technique, both full-order and reduced-order robust L 1 filter with suitable dynamic behavior can be obtained from the solution of convex optimization problems. Compared with earlier result in the quadratic framework, this approach turns out to be less conservative. The efficiency of the proposed technique is demonstrated by a numerical example.
基金supported by the National Natural Science Foundation of China (6090405161021002)
文摘The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain systems are developed with the benefit of the scalar multi-convex function. To be convenient for applications, such conditions are simplified into new linear matrix inequality （LMI） conditions, which can be solved by the powerful LMI toolbox. Numerical examples are provided to indicate that this new approach is less conservative than previous results for Hurwitz stability, Schur stability and D-stability of uncertain systems under certain circumstances.
基金Project (60425310) supported by the National Science Foundation of China project (2001AA4422200) supported by theTeaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of the Ministry of Education of China
文摘A design method for controllers and a comprehensive stability analysis for an acrobat based on Lyapunov functions are presented. Three control laws based on three Lyapunov functions are designed to increase the energy so as to move the acrobot into the unstable inverted equilibrium position, and solve the problem of posture and energy. The concept of a non-smooth Lyapunov function is employed to analyze the stability of the whole system. The validity of this strategy is demonstrated by simulations.
