Objective:To investigate the adjusting malnutrition mechanism by the Reinforcing Kidney and Exhausting Toxic Mixture(REM)on the chronic renal failure (CRF) rat.Methods:60 wistar rats weved ivided into 3 groups randoml...Objective:To investigate the adjusting malnutrition mechanism by the Reinforcing Kidney and Exhausting Toxic Mixture(REM)on the chronic renal failure (CRF) rat.Methods:60 wistar rats weved ivided into 3 groups randomly :the normal controc group(group Ⅰ),CRF group(group Ⅱ),and CRF rat perfusingwithREM group(group Ⅲ). Taking theirfat,kidneytissuefor detecting the protein expression of the leptin,leptin receptor(Ob-R) by the means ofimmunohistochemistry.Result:Comparing with control group, the leptinprotein express intensely in CRF rat ; In kidney tissue,the ob-R express weakly. After perfusing the REM ,comparing with CRF groupthe renal ob-R express strongly than CRF group. Conclusion: Maybe the REM could do a little better with the malnutritionof CRFratsby adjusttingthe activity of ob-R in kidney.展开更多
文摘Objective:To investigate the adjusting malnutrition mechanism by the Reinforcing Kidney and Exhausting Toxic Mixture(REM)on the chronic renal failure (CRF) rat.Methods:60 wistar rats weved ivided into 3 groups randomly :the normal controc group(group Ⅰ),CRF group(group Ⅱ),and CRF rat perfusingwithREM group(group Ⅲ). Taking theirfat,kidneytissuefor detecting the protein expression of the leptin,leptin receptor(Ob-R) by the means ofimmunohistochemistry.Result:Comparing with control group, the leptinprotein express intensely in CRF rat ; In kidney tissue,the ob-R express weakly. After perfusing the REM ,comparing with CRF groupthe renal ob-R express strongly than CRF group. Conclusion: Maybe the REM could do a little better with the malnutritionof CRFratsby adjusttingthe activity of ob-R in kidney.
