This paper for first time proposes an isogeometric analysis (IGA) for free vibration response of bi-directional functionally graded (BDFG) rectangular plates in the fluid medium. Material properties of the BDFG plate ...This paper for first time proposes an isogeometric analysis (IGA) for free vibration response of bi-directional functionally graded (BDFG) rectangular plates in the fluid medium. Material properties of the BDFG plate change in both the thickness and length directions via power-law distributions and Mori-Tanaka model. The governing equation of motion of BDFG plate in the fluid-plate system is formulated basing on Hamilton's principle and the refined quasi three-dimensional (3D) plate theory with improved function f(z). The fluid velocity potential is derived from the boundary conditions of the fluid-plate system and is used to determine the added mass. The discrete system of equations is derived from the Galerkin weak form and numerically analyzed by IGA. The accuracy and reliability of the proposed solutions are verified by comparing the obtained results with those published in the literature. Moreover, the effects of the various parameters such as the interaction boundary condition, geometric parameter, submerged depth of plate, fluid density, fluid level, and the material volume control coefficients on the free vibration behavior of BDFG plate in the fluid medium are investigated in detail. Some major findings regarding the numerical results are withdrawn in conclusions.展开更多
目的探讨柴胡皂苷D调控CaMKKβ/AMPK信号通路,在功能性消化不良中对胃肠道Cajal间质细胞(Interstitial cells of Cajal,ICCs)细胞自噬的作用及机制。方法分离大鼠原代ICCs细胞,谷氨酸刺激构建ICCs自噬模型,免疫荧光检测Ca2+水平。将原代...目的探讨柴胡皂苷D调控CaMKKβ/AMPK信号通路,在功能性消化不良中对胃肠道Cajal间质细胞(Interstitial cells of Cajal,ICCs)细胞自噬的作用及机制。方法分离大鼠原代ICCs细胞,谷氨酸刺激构建ICCs自噬模型,免疫荧光检测Ca2+水平。将原代ICCs细胞分为对照组、模型组、模型+柴胡皂苷D组、模型+CaMKKβ抑制剂组、模型+柴胡皂苷D+CaMKKβ抑制剂组。透射电镜观察自噬体超微结构,ELISA检测Ghrelin和SP的水平,免疫荧光检测Ca2+和LC-3Ⅱ的表达,Western blot检测LC-3Ⅱ/Ⅰ、CaMKKβ、p-AMPK、Drp1、MFN2、IP3R和RyR的蛋白表达水平。结果谷氨酸诱导的模型组ICCs中LC-3Ⅱ荧光表达增强。柴胡皂苷D干预可降低Ca2+浓度,降低CaMKKβ、AMPK和MFN2水平(P<0.01),增加LC-3Ⅱ/Ⅰ、IP3R、RyR、Drp1、Ghrelin和SP水平(P<0.01)。柴胡皂苷D联合CaMKKβ抑制剂STO-609干预后效果更显著。结论柴胡皂苷D可通过CaMKKβ/AMPK信号通路介导Ca2+外流,影响ICCs细胞过度自噬及胃肠动力相关因子的表达。展开更多
This manuscript presents the comprehensive study of thickness stretching effects on the free vibration,static stability and bending of multilayer functionally graded(FG)carbon nanotubes reinforced composite(CNTRC)nano...This manuscript presents the comprehensive study of thickness stretching effects on the free vibration,static stability and bending of multilayer functionally graded(FG)carbon nanotubes reinforced composite(CNTRC)nanoplates.The nanoscale and microstructure influences are considered through a modified nonlocal strain gradient continuum model.Based on power-law functions,four different patterns of CNTs distribution are considered in this analysis,a uniform distribution UD,FG-V CNTRC,FG-X CNTRC,and FG-O CNTRC.A 3D kinematic shear deformation theory is proposed to include the stretching influence,which is neglected in classical theories.Hamilton's principle is applied to derive the governing equations of motion and associated boundary conditions.Analytical solutions are developed based on Galerkin method to solve the governing equilibrium equations based on the generalized higher-order shear deformation theory and the nonlocal strain gradient theory and get the static bending,buckling loads,and natural frequencies of nanoplates.Verification with previous works is presented.A detailed parametric analysis is carried out to highlight the impact of thickness stretching,length scale parameter(nonlocal),material scale parameter(gradient),CNTs distribution pattern,geometry of the plate,various boundary conditions and the total number of layers on the stresses,deformation,critical buckling loads and vibration frequencies.Many new results are also reported in the current study,which will serve as a benchmark for future research.展开更多
The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain syst...The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain systems are developed with the benefit of the scalar multi-convex function. To be convenient for applications, such conditions are simplified into new linear matrix inequality （LMI） conditions, which can be solved by the powerful LMI toolbox. Numerical examples are provided to indicate that this new approach is less conservative than previous results for Hurwitz stability, Schur stability and D-stability of uncertain systems under certain circumstances.展开更多
基金This research is funded by Vietnam National Foundation for Science and Technology Development(NAFOSTED)under Grant number 107.02-2019.330.
文摘This paper for first time proposes an isogeometric analysis (IGA) for free vibration response of bi-directional functionally graded (BDFG) rectangular plates in the fluid medium. Material properties of the BDFG plate change in both the thickness and length directions via power-law distributions and Mori-Tanaka model. The governing equation of motion of BDFG plate in the fluid-plate system is formulated basing on Hamilton's principle and the refined quasi three-dimensional (3D) plate theory with improved function f(z). The fluid velocity potential is derived from the boundary conditions of the fluid-plate system and is used to determine the added mass. The discrete system of equations is derived from the Galerkin weak form and numerically analyzed by IGA. The accuracy and reliability of the proposed solutions are verified by comparing the obtained results with those published in the literature. Moreover, the effects of the various parameters such as the interaction boundary condition, geometric parameter, submerged depth of plate, fluid density, fluid level, and the material volume control coefficients on the free vibration behavior of BDFG plate in the fluid medium are investigated in detail. Some major findings regarding the numerical results are withdrawn in conclusions.
文摘目的探讨柴胡皂苷D调控CaMKKβ/AMPK信号通路,在功能性消化不良中对胃肠道Cajal间质细胞(Interstitial cells of Cajal,ICCs)细胞自噬的作用及机制。方法分离大鼠原代ICCs细胞,谷氨酸刺激构建ICCs自噬模型,免疫荧光检测Ca2+水平。将原代ICCs细胞分为对照组、模型组、模型+柴胡皂苷D组、模型+CaMKKβ抑制剂组、模型+柴胡皂苷D+CaMKKβ抑制剂组。透射电镜观察自噬体超微结构,ELISA检测Ghrelin和SP的水平,免疫荧光检测Ca2+和LC-3Ⅱ的表达,Western blot检测LC-3Ⅱ/Ⅰ、CaMKKβ、p-AMPK、Drp1、MFN2、IP3R和RyR的蛋白表达水平。结果谷氨酸诱导的模型组ICCs中LC-3Ⅱ荧光表达增强。柴胡皂苷D干预可降低Ca2+浓度,降低CaMKKβ、AMPK和MFN2水平(P<0.01),增加LC-3Ⅱ/Ⅰ、IP3R、RyR、Drp1、Ghrelin和SP水平(P<0.01)。柴胡皂苷D联合CaMKKβ抑制剂STO-609干预后效果更显著。结论柴胡皂苷D可通过CaMKKβ/AMPK信号通路介导Ca2+外流,影响ICCs细胞过度自噬及胃肠动力相关因子的表达。
基金supported by The Algerian General Directorate of Scientific Research and Technological Development(DGRSDT)University of Mustapha Stambouli of Mascara(UMS Mascara)in Algeria。
文摘This manuscript presents the comprehensive study of thickness stretching effects on the free vibration,static stability and bending of multilayer functionally graded(FG)carbon nanotubes reinforced composite(CNTRC)nanoplates.The nanoscale and microstructure influences are considered through a modified nonlocal strain gradient continuum model.Based on power-law functions,four different patterns of CNTs distribution are considered in this analysis,a uniform distribution UD,FG-V CNTRC,FG-X CNTRC,and FG-O CNTRC.A 3D kinematic shear deformation theory is proposed to include the stretching influence,which is neglected in classical theories.Hamilton's principle is applied to derive the governing equations of motion and associated boundary conditions.Analytical solutions are developed based on Galerkin method to solve the governing equilibrium equations based on the generalized higher-order shear deformation theory and the nonlocal strain gradient theory and get the static bending,buckling loads,and natural frequencies of nanoplates.Verification with previous works is presented.A detailed parametric analysis is carried out to highlight the impact of thickness stretching,length scale parameter(nonlocal),material scale parameter(gradient),CNTs distribution pattern,geometry of the plate,various boundary conditions and the total number of layers on the stresses,deformation,critical buckling loads and vibration frequencies.Many new results are also reported in the current study,which will serve as a benchmark for future research.
基金supported by the National Natural Science Foundation of China (6090405161021002)
文摘The problem of the robust D-stability analysis for linear systems with parametric uncertainties is addressed. For matrix polytopes, new conditions via the affine parameter-dependent Lyapunov function of uncertain systems are developed with the benefit of the scalar multi-convex function. To be convenient for applications, such conditions are simplified into new linear matrix inequality （LMI） conditions, which can be solved by the powerful LMI toolbox. Numerical examples are provided to indicate that this new approach is less conservative than previous results for Hurwitz stability, Schur stability and D-stability of uncertain systems under certain circumstances.
