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A series of iridium(Ⅲ)complexes with fluorophenyl isoquinoline ligand and low-efficiency roll-off properties:A density functional theory study
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作者 QIN Zhengkun PAN Zicong +2 位作者 TIAN Hui ZHANG Wanyi SONG Mingxing 《无机化学学报》 北大核心 2025年第6期1235-1244,共10页
We have examined the theoretical implications of combining two main and three auxiliary ligands to form several Ir(Ⅲ)complexes featuring a transition metal as their core atom to identify some appropriate organic ligh... We have examined the theoretical implications of combining two main and three auxiliary ligands to form several Ir(Ⅲ)complexes featuring a transition metal as their core atom to identify some appropriate organic lightemitting diode(OLED)materials.By utilizing electronic structure,frontier molecular orbitals,minimum single-line absorption,triplet excited states,and emission spectral data derived from the density functional theory,the usefulness of these Ir(Ⅲ)complexes,including(piq)_(2)Ir(acac),(piq)_(2)Ir(tmd),(piq)_(2)Ir(tpip),(fpiq)_(2)Ir(acac),(fpiq)_(2)Ir(tmd),and(fpiq)_(2)Ir(tpip),in OLEDs was examined,where piq=1-phenylisoquinoline,fpiq=1-(4-fluorophenyl)isoquinoline,acac=(3Z)-4-hydroxypent-3-en-2-one,tmd=(4Z)-5-hydroxy-2,2,6,6-tetramethylhept-4-en-3-one,and tpip=tetraphenylimido-diphosphonate.These complexes all have low-efficiency roll-off properties,especially(fpiq)_(2)Ir(tpip).Some researchers have successfully synthesized complexes extremely similar to(piq)_(2)Ir(acac)through the Suzuki-Miyaura coupling reaction. 展开更多
关键词 density functional theory organic light-emitting diodes luminescent materials Ir(Ⅲ)complexes
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A new theory for determining large deformation area of roof at intersection and verification analysis
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作者 WU Yi-yi GAO Yu-bing +2 位作者 MA Xiang ZHANG Xing-xing HE Man-chao 《Journal of Central South University》 2025年第2期656-677,共22页
The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying t... The intersection is a widely used traffic line structure from the shallow tunnel to the deep roadway,and determining the subsidence hidden danger area of the roof is the key to its stability control.However,applying traditional maximum equivalent span beam(MESB)theory to determine deformation range,peak point,and angle influence poses a challenge.Considering the overall structure of the intersection roof,the maximum equivalent triangular plate(METP)theory is proposed,and its geometric parameter calculation formula and deflection calculation formula are obtained.The application of the two theories in 18 models with different intersection angles,roadway types,and surrounding rock lithology is verified by numerical analysis.The results show that:1)The METP structure of the intersection roof established by the simulation results of each model successfully determined the location of the roof’s high displacement zone;2)The area comparison method of the METP theory can be reasonably explained:①The roof subsidence of the intersection decreases with the increase of the intersection angle;②The roof subsidence at the intersection of different roadway types has a rectangular type>arch type>circular type;③The roof subsidence of the intersection with weak surrounding rock is significantly larger than that of the intersection with hard surrounding rock.According to the application results of the two theories,the four advantages of the METP theory are compared and clarified in the basic assumptions,mechanical models,main viewpoints,and mechanism analysis.The large deformation inducement of the intersection roof is then explored.The J 2 peak area of the roof drives the large deformation of the area,the peak point of which is consistent with the center of gravity position of the METP.Furthermore,the change in the range of this peak is consistent with the change law of the METP’s area.Hence,this theory clarifies the large deformation area of the intersection roof,which provides a clear guiding basis for its initial support design,mid-term monitoring,and late local reinforcement. 展开更多
关键词 roadway intersection roof deformation equivalent span theory triangular plate structure numerical analysis stress partial tensor
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Prediction and critical transition mechanism for granite fracture:Insights from critical slowing down theory 被引量:2
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作者 WANG Chun-lai ZHOU Bao-kun +6 位作者 LI Chang-feng WEN Zhi-jie BAI Zhi-an ZHU Chao-yang SUN Liang XUE Xu-hui CAO Peng 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2748-2764,共17页
Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteris... Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteristics of AE signals preceding granite fracture,based on the critical slowing down(CSD)theory.The granite undergoes a transition from the stable phase to the fracture phase and exhibits a clear CSD phenomenon,characterized by a pronounced increase in variance and autocorrelation coefficient.The variance mutation points were found to be more identifiable and suitable as the primary criterion for predicting precursor information related to granite fracture,compared to the autocorrelation coefficient.It is noteworthy to emphasize that the CSD factor holds greater potential in elucidating the underlying mechanisms responsible for the critical transition of granite fracture,in comparison to the AE timing parameters.Furthermore,a novel multi-parameter collaborative prediction method for rock fracture was developed by comprehensively analyzing predictive information,including abnormal variation modes and the CSD factor of AE characteristic parameters.This method enhances the understanding and prediction of rock fracture-related geohazards. 展开更多
关键词 GRANITE triaxial compression acoustic emission rock fracture critical slowing down theory
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Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach 被引量:1
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作者 Thuy Tran Thi Thu Tu Nguyen Anh +1 位作者 Hue Nguyen Thi Hong Nguyen Thi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第8期171-193,共23页
Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties... Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures. 展开更多
关键词 Blast load Modified first-order shear theory Biological composite structures
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Complex adaptive system theory,agent-based modeling,and simulation in dominant technology formation 被引量:1
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作者 ZHANG Ruihan SUN Bing 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2024年第1期130-153,共24页
Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to i... Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and mechanism.Specifically,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical landscape.The results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and adaptability.Therein,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical landscape.There is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different effects.This study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies. 展开更多
关键词 complex adaptive system theory agent-based modeling and simulation dominant technology socio-technical landscape adaptation-choice
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Belief exponential divergence for D-S evidence theory and its application in multi-source information fusion 被引量:2
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作者 DUAN Xiaobo FAN Qiucen +1 位作者 BI Wenhao ZHANG An 《Journal of Systems Engineering and Electronics》 CSCD 2024年第6期1454-1468,共15页
Dempster-Shafer evidence theory is broadly employed in the research of multi-source information fusion.Nevertheless,when fusing highly conflicting evidence it may pro-duce counterintuitive outcomes.To address this iss... Dempster-Shafer evidence theory is broadly employed in the research of multi-source information fusion.Nevertheless,when fusing highly conflicting evidence it may pro-duce counterintuitive outcomes.To address this issue,a fusion approach based on a newly defined belief exponential diver-gence and Deng entropy is proposed.First,a belief exponential divergence is proposed as the conflict measurement between evidences.Then,the credibility of each evidence is calculated.Afterwards,the Deng entropy is used to calculate information volume to determine the uncertainty of evidence.Then,the weight of evidence is calculated by integrating the credibility and uncertainty of each evidence.Ultimately,initial evidences are amended and fused using Dempster’s rule of combination.The effectiveness of this approach in addressing the fusion of three typical conflict paradoxes is demonstrated by arithmetic exam-ples.Additionally,the proposed approach is applied to aerial tar-get recognition and iris dataset-based classification to validate its efficacy.Results indicate that the proposed approach can enhance the accuracy of target recognition and effectively address the issue of fusing conflicting evidences. 展开更多
关键词 Dempster-Shafer(D-S)evidence theory multi-source information fusion conflict measurement belief expo-nential divergence(BED) target recognition
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A density functional theory study of polarons on different TiO_(2) surfaces
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作者 SHI Zhiqun GONG Xueqing 《燃料化学学报(中英文)》 EI CAS CSCD 北大核心 2024年第12期1877-1888,I0011-I0013,共15页
Polarons are widely considered to play a crucial role in the charge transport and photocatalytic performance of materials,but the mechanisms of their formation and the underlying driving factors remain a matter of con... Polarons are widely considered to play a crucial role in the charge transport and photocatalytic performance of materials,but the mechanisms of their formation and the underlying driving factors remain a matter of controversy.This study delves into the formation of polarons in different crystalline forms of TiO_(2) and their connection with the materials'structure.By employing density functional theory calculations with on-site Coulomb interaction correction(DFT+U),we provide a detailed analysis of the electronic polarization behavior in the anatase and rutile forms of TiO_(2).We focus on the polarization properties of defect-induced and photoexcited excess electrons on various TiO_(2) surfaces.The results reveal that the defect electrons can form small polarons on the anatase TiO_(2)(101)surface,while on the rutile TiO_(2)(110)surface,both small and large polarons(hybrid-state polarons)are formed.Photoexcited electrons are capable of forming both small and large polarons on the surfaces of both crystal types.The analysis indicates that the differences in polaron distribution are primarily determined by the intrinsic properties of the crystals;the structural and symmetry differences between anatase and rutile TiO_(2) lead to the distinct polaron behaviors.Further investigation suggests that the polarization behavior of defect electrons is also related to the arrangement of electron orbitals around the Ti atoms,while the polarization of photoexcited electrons is mainly facilitated by the lattice distortions.These findings elucidate the formation mechanisms of different types of polarons and may contribute to understanding the performance of TiO_(2)in different fields. 展开更多
关键词 POLARON surface defect PHOTOEXCITATION TiO_(2) density functional theory
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Design of a Metasurface Antenna Based on Characteristic Mode Theory
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作者 HE Huan 《电讯技术》 北大核心 2024年第10期1561-1568,共8页
A novel metasurface antenna consisting of 5×5 rectangular patch elements is presented.Thestructure with and without the central element are both analyzed by the Characteristic Mode Theory(CMT).The developed mutua... A novel metasurface antenna consisting of 5×5 rectangular patch elements is presented.Thestructure with and without the central element are both analyzed by the Characteristic Mode Theory(CMT).The developed mutually orthogonal principal modes of the optimized periodic patch structure areexcited by a center-feed dipole.A differential feeding network is employed to realize impedance matching.Prototype with profile height of 0.07λ_(0)(λ_(0)is the wavelength in free space at the lowest operatingfrequency)is fabricated and assembled to verify the simulation results.The measured results show that thereflectance coefficient of proposed matesurface antenna is less than-10 dB in the whole operating bandrange from 4.2 GHz to 5.5 GHz,a relative bandwidth of 26.8%is achieved,and the maximummeasured realized gain is more than 9 dBi with a maximum radiation efficiency of 90%.The designprovides a guideline on the application of characteristic modes(CMs)to radiation problems. 展开更多
关键词 metasurface antenna characteristic mode theory dipole antenna realized gain
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A new method for evaluating the firing precision of multiple launch rocket system based on Bayesian theory
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作者 Yunfei Miao Guoping Wang Wei Tian 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期232-241,共10页
How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS consi... How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%. 展开更多
关键词 Multiple launch rocket system Bayesian theory Simulation credibility Mixed prior distribution Firing precision
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基于卫气理论谈卫气物质基础的研究进展与思考 被引量:1
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作者 董国菊 梁小雨 +1 位作者 郝校鹏 黄璐琦 《中华中医药学刊》 北大核心 2025年第3期1-5,共5页
卫气理论是中医重要的基础理论之一,源于《内经》,又经后世医家不断阐发,在中医临床诊治中起着重要作用。对卫气的生成、卫气的特性、卫气的功能和卫气的运行规律进行了系统梳理,在此基础上,对卫气物质基础的现代研究进展进行了总结。... 卫气理论是中医重要的基础理论之一,源于《内经》,又经后世医家不断阐发,在中医临床诊治中起着重要作用。对卫气的生成、卫气的特性、卫气的功能和卫气的运行规律进行了系统梳理,在此基础上,对卫气物质基础的现代研究进展进行了总结。研究显示,卫气与免疫系统、神经系统、线粒体、膏脂等在功能、分布或者运行节律上具有一定的相关性,但都不能完全涵盖卫气理论内容。今后的研究应从整体观念出发,通过与现代医学体系对话,多学科交叉合作,深入探讨能代表卫气功能的潜在物质基础。同时要注意去伪存真,在传承中创新,实现卫气理论创造性的研究和发展模式,为推进中医药现代化进程提供思路和借鉴。 展开更多
关键词 卫气 卫气理论 物质基础 科学内涵 免疫系统 神经系统 线粒体 膏脂
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Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory
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作者 LI Liang CHEN Jia-jun +3 位作者 ZHAO Lian-heng HE Ke-pei HU Shi-hong LI Hua-long 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2341-2364,共24页
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety risks.However,previous theoretical studies on the range of blasting-in... Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety risks.However,previous theoretical studies on the range of blasting-induced cracks often ignore the impact of the in-situ stress,especially that of the intermediate principal stress.The particle displacement−crack radius relationship was established in this paper by utilizing the blasthole cavity expansion equation,and theoretical analytical formulas of the stress−displacement relationship and the crack radius were derived with unified strength theory to accurately assess the range of cracks in deep surrounding rock under a blasting load.Parameter analysis showed that the crushing zone size was positively correlated with in-situ stress,intermediate principal stress,and detonation pressure,whereas negatively correlated with Poisson ratio and decoupling coefficient.The dilatancy angle-crushing zone size relationship exhibited nonmonotonic behavior.The relationships in the crushing zone and the fracture zone exhibited opposite trends under the influence of only in-situ stress or intermediate principal stress.As the in-situ stress increased from 0 to 70 MPa,the rate of change in the crack range and the attenuation rate of the peak vibration velocity gradually slowed. 展开更多
关键词 deep drilling and blasting cracks in surrounding rock unified strength theory intermediate principle stress in-situ stress cavity expansion dilatancy characteristics
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基于“气道涩、五脏之气相搏”探讨针刺治疗围绝经期失眠 被引量:1
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作者 王健 任路 《辽宁中医杂志》 北大核心 2025年第4期47-50,共4页
基于“气道涩、五脏之气相搏”探讨针刺治疗围绝经期失眠的思路。营卫循行有度是睡眠的基础,营卫功能状态下降或营卫运行受阻都可以引起失眠,运行通道也会出现失用与失荣。围绝经期失眠是由于天癸竭导致生殖轴被截断,阴阳平衡关系被打破... 基于“气道涩、五脏之气相搏”探讨针刺治疗围绝经期失眠的思路。营卫循行有度是睡眠的基础,营卫功能状态下降或营卫运行受阻都可以引起失眠,运行通道也会出现失用与失荣。围绝经期失眠是由于天癸竭导致生殖轴被截断,阴阳平衡关系被打破,出现一时混乱所引起。围绝经失眠主要发病机制为肾虚,病位主要在心,与肝、脾最为密切。肾为元阴元阳之根本,肾精亏虚,营卫之气的生成与运行失常;肾虚又会引起其他脏腑气机紊乱和阴阳的失衡,营卫进一步失衡而出现失眠。治疗上首取膀胱经,与督脉、手足少阴经等诸经相合,使得气道通,五脏安和,昼精而夜暝。“气道涩、五脏之气相搏”可执简驭繁地抓住病机关键点,综合治疗可提高针刺的临床疗效。 展开更多
关键词 气道 五脏 针刺 围绝经期 失眠
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基于五运六气理论的针疗法对青光眼眼压控制及视神经功能修复的效果评估
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作者 郑丽凤 黎海平 +4 位作者 吴西西 赵建英 赵颖 李银鑫 邢远 《中华中医药学刊》 北大核心 2025年第6期179-182,共4页
目的研究基于五运六气理论的针疗法对青光眼眼压控制及视神经功能修复的效果。方法选取2022年1月—2022年12月于医院治疗的青光眼患者140例,随机均分为两组、每组70例,对照组患者应用常规西医治疗,观察组患者在对照组基础上,进行基于五... 目的研究基于五运六气理论的针疗法对青光眼眼压控制及视神经功能修复的效果。方法选取2022年1月—2022年12月于医院治疗的青光眼患者140例,随机均分为两组、每组70例,对照组患者应用常规西医治疗,观察组患者在对照组基础上,进行基于五运六气理论的针疗法,治疗4周后比较两组患者的治疗有效率、眼压、视野指标[平均光敏感度(Mean sensitivity,MS)、平均缺损(Mean deviation,MD)、丢失方差(Loss variance,LV)]、视神经指标[图形视觉诱发电位(pat-tern visual evoked potential,P-VEP)振幅及潜伏期]及不良反应情况。结果观察组总有效率97.14%,显著高于对照组87.14%,组间差异有统计学意义(P<0.05)。治疗后两组患者眼压均显著降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后两组患者视野指标MS显著增高,MD、LV显著降低,与同组治疗前比较差异有统计学意义(P<0.05);治疗后观察组MS显著高于对照组,MD、LV显著低于对照组,组间差异有统计学意义(P<0.05)。治疗后两组P-VEP振幅增高,P-VEP潜伏期缩短,与同组治疗前比较差异有统计学意义(P<0.05);治疗后观察组P-VEP振幅显著高于对照组,P-VEP潜伏期显著短于对照组,差异有统计学意义(P<0.05)。观察组、对照组不良反应发生率分别为8.57%、5.71%,差异无统计学意义(P>0.05),不良反应症状均可自行缓解。结论基于五运六气理论的针疗法应用于青光眼患者效果满意,能够更好地控制眼压、修复视神经功能,是安全、有效地治疗方案,值得借鉴应用。 展开更多
关键词 青光眼 针疗法 五运六气理论 眼压 视神经
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电机气隙磁场调制统一理论研究进展与展望 被引量:4
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作者 程明 马钲洲 +2 位作者 花为 汪波 王政 《中国电机工程学报》 北大核心 2025年第4期1220-1236,I0001,共18页
电机气隙磁场调制统一理论于2017年由作者团队提出以来,便因在电机原理分析、性能计算和拓扑创新方面的优势,成为行业内的热点研究方向,经过多年的深入研究,在电机气隙磁场调制机理、气隙磁场调制数学表征方法等方面取得了多项原创性成... 电机气隙磁场调制统一理论于2017年由作者团队提出以来,便因在电机原理分析、性能计算和拓扑创新方面的优势,成为行业内的热点研究方向,经过多年的深入研究,在电机气隙磁场调制机理、气隙磁场调制数学表征方法等方面取得了多项原创性成果。该文从理论、技术和应用3个层面综述电机气隙磁场调制理论的最新研究进展,包括:提出磁感、磁容调制器,将磁场调制模态拓展为频率调制、幅值调制和相位调制,提出“基波+谐波”的多工作波电机设计思想等,厘清电机气隙磁场调制理论与传统电机理论的关系等。最后,对气隙磁场调制统一理论未来研究与发展方向进行展望。 展开更多
关键词 电机理论 磁场调制理论 谐波利用 多工作波电机 矢量磁路理论 磁感 电能
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“路径-目标”理论视角下公立医院发展型绩效考核实施的质性研究 被引量:3
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作者 魏万宏 胡佳奇 +2 位作者 周珂 陈艳红 侯梦园 《中国医院》 北大核心 2025年第4期1-6,共6页
目的:探讨公立医院发展型绩效考核的实施对组织发展的影响机制。方法:采用目的抽样方法,选取河南省5所三级甲等公立医院职能部门或医疗部门的医务人员共25人为研究对象。基于质性研究的扎根理论方法,以“路径-目标”理论为视角,使用Maxq... 目的:探讨公立医院发展型绩效考核的实施对组织发展的影响机制。方法:采用目的抽样方法,选取河南省5所三级甲等公立医院职能部门或医疗部门的医务人员共25人为研究对象。基于质性研究的扎根理论方法,以“路径-目标”理论为视角,使用Maxqda 2022软件分析访谈材料。结果:明确的目标导向和精细化管理是确保绩效考核有效执行的关键。高水平的组织情感承诺和公共服务动机显著提升员工内在动力,优化组织氛围,增强归属感和团队协作能力,从而推动绩效考核和组织目标的实现。结论:医院管理者应进一步优化领导策略,改善外部环境,细化任务结构,增强组织情感承诺和公共服务动机,确保政策执行的稳定性,推动公立医院绩效考核的持续改进和创新,助力实现高质量的医疗服务和组织发展目标。 展开更多
关键词 公立医院 “路径-目标”理论 绩效考核 组织发展 扎根理论
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黄芪-莪术-蚤休配伍调控PINK1/Parkin信号通路抑制小鼠结肠癌生长转移的研究 被引量:1
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作者 陈思 梁众擎 +5 位作者 苏婷婷 张慧兰 梁研 祁恒奕 陈怀祖 唐德才 《南京中医药大学学报》 北大核心 2025年第4期473-482,共10页
目的探讨黄芪-莪术-蚤休(芪-术-蚤)角药配伍基于PINK1/Parkin/EMT信号通路抑制结肠癌生长和转移的影响。方法30只BALB/c雄性小鼠,随机分为空白组、模型组、阳性对照组、芪-术-蚤高剂量组(5.85 g·kg^(-1))、芪-术-蚤低剂量组(2.925 ... 目的探讨黄芪-莪术-蚤休(芪-术-蚤)角药配伍基于PINK1/Parkin/EMT信号通路抑制结肠癌生长和转移的影响。方法30只BALB/c雄性小鼠,随机分为空白组、模型组、阳性对照组、芪-术-蚤高剂量组(5.85 g·kg^(-1))、芪-术-蚤低剂量组(2.925 g·kg^(-1)),每组6只,使用结肠癌CT26.WT细胞构建小鼠原位结肠癌模型。给药15 d后,取各组小鼠肿瘤、肝脏组织,HE病理染色评估肿瘤转移情况,透射电镜观察肿瘤组织线粒体自噬现象,Western blot、免疫组化(IHC)检测线粒体自噬相关蛋白PINK1、Parkin、p62、LC3-Ⅱ/LC3-Ⅰ表达情况,Western blot、qPCR、IHC检测EMT相关E-cadherin、N-cadherin、Vimentin、Snail蛋白和mRNA表达情况。结果与模型组相比,给药组小鼠肿瘤体积明显变小、转移灶数目变少,肝脏组织发生改变,小鼠生长状态得到明显改善;芪-术-蚤给药组肿瘤组织线粒体发生了选择性自噬现象,伴随着自噬小体的产生;芪-术-蚤给药组影响了PINK1/Parkin通路介导的线粒体自噬生物学过程:PINK1、Parkin、p62、LC3-Ⅱ/LC3-Ⅰ均有一定程度上调(P<0.05,P<0.01),且高剂量组效果优于低剂量组(P<0.05,P<0.01);芪-术-蚤给药组降低了EMT相关N-cadherin、Vimentin、Snail的蛋白含量与mRNA水平(P<0.05,P<0.01),同时增高了E-cadherin的蛋白与mRNA水平(P<0.05,P<0.01),且高剂量组均优于低剂量组(P<0.05,P<0.01)。结论芪-术-蚤角药配伍一定程度抑制结肠癌原位移植瘤小鼠模型肿瘤生长和转移,其机制可能是通过PINK1/Parkin信号通路扭转线粒体功能异常,抑制上皮-间质转化(EMT)过程,达到治疗结肠癌的作用。 展开更多
关键词 芪-术-蚤 线粒体自噬 PINK1/Parkin信号通路 上皮-间质转化 结肠癌
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基于“气络学说”探讨铜死亡对糖尿病心肌病的影响
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作者 林玉婷 余昆 +3 位作者 陈飞 李滨 欧阳秋芳 郭进建 《世界科学技术-中医药现代化》 北大核心 2025年第8期2176-2182,共7页
糖尿病心肌病(Diabetic cardiomyopathy,DCM)是糖尿病并发症之一,起病隐匿,易被忽视,后期心肌损伤严重,预后较差,目前临床以对症治疗为主。铜死亡是体内铜离子浓度失衡引起的线粒体代谢异常的新型细胞死亡模式,是DCM的重要机制之一,靶... 糖尿病心肌病(Diabetic cardiomyopathy,DCM)是糖尿病并发症之一,起病隐匿,易被忽视,后期心肌损伤严重,预后较差,目前临床以对症治疗为主。铜死亡是体内铜离子浓度失衡引起的线粒体代谢异常的新型细胞死亡模式,是DCM的重要机制之一,靶向铜死亡途径治疗DCM是目前研究的重点和热点。“气络学说”是络病理论的学科分支之一,是主运行经气系统的学说,络病-心血管的证治体系对DCM的论治具有重要的指导意义。中医学认为,络气虚滞是DCM的发病之源,瘀毒阻络,心络受损是病变核心,心之气血阴阳虚衰是最终转归。“气络学说”和铜死亡在生理功能、病变过程具有相似之处,铜死亡可以说是“气络学说”的微观表现之一。基于此,本文提出了补虚行滞为常,攻补兼施为纲,扶正固本为核的分期治疗原则,以期为临床论治DCM提供理论参考。 展开更多
关键词 糖尿病心肌病 气络学说 铜死亡 中医药 中西医结合
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中国和美乡村建设的理论与实践——乡村场景价值理论的视角 被引量:1
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作者 杨庆媛 王愈滋 +3 位作者 杨人豪 苏康传 王笛 孙朝辉 《西南大学学报(自然科学版)》 北大核心 2025年第4期1-15,共15页
目前,和美乡村建设的研究主要集中在政策分析和个案描述,亟需更加深入的理论研究。将场景理论与乡村多元价值理论有机结合,构建乡村场景价值理论,强调乡村多元价值在多种场景中的“生成—互动—反馈”逻辑,揭示各类价值在不同场景中的... 目前,和美乡村建设的研究主要集中在政策分析和个案描述,亟需更加深入的理论研究。将场景理论与乡村多元价值理论有机结合,构建乡村场景价值理论,强调乡村多元价值在多种场景中的“生成—互动—反馈”逻辑,揭示各类价值在不同场景中的显化过程;利用“乡村场景价值理论”分析框架,对成都市多利桃花源和重庆市武隆犀牛古寨乡村建设和发展进行案例分析,证实理论框架的适用性,进一步阐明差异化核心场景在乡村价值生成、互动和反馈中的引领作用。 展开更多
关键词 和美乡村 场景理论 乡村多元价值理论 乡村场景价值理论
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数字化转型赋能制造业新质生产力发展——基于资源基础理论与动态能力理论的实证研究 被引量:11
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作者 赵巧芝 郭紫晴 《工业技术经济》 北大核心 2025年第1期12-24,共13页
通过数字化转型引领新质生产力的发展,是数字经济赋能制造强国建设的重要课题。本文基于资源基础论与动态能力理论,剖析数字化转型驱动制造企业新质生产力发展的影响机理,为赋能新质生产力提供参考。结果发现:(1)数字化转型对制造企业... 通过数字化转型引领新质生产力的发展,是数字经济赋能制造强国建设的重要课题。本文基于资源基础论与动态能力理论,剖析数字化转型驱动制造企业新质生产力发展的影响机理,为赋能新质生产力提供参考。结果发现:(1)数字化转型对制造企业新质生产力的长期与短期影响存在差异,短期表现为提升整合、配置及运用资源能力,长期表现为增强其创新变革的感知、抓取与转化能力;(2)实证结果表明,数字化转型对新质生产力的影响显著为正。其中,短期影响的正向作用显著,长期影响不显著。不仅如此,市场竞争强度的正向调节作用不容忽视;(3)根据异质性效应结果,东部地区影响显著为正,中部与西部地区则较为微弱;国有企业的驱动效应明显高于非国有企业样本。研究结论为提升制造业新质生产力水平提供了新的赋能方向。 展开更多
关键词 数字化转型 制造业 新质生产力 资源基础论 动态能力理论 赋能机制 市场竞争强度 异质性效应
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TRIZ辅助红松虫害检测机器人概念设计
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作者 付敏 高风 +1 位作者 高泽飞 郝镒林 《机械设计与制造》 北大核心 2025年第8期106-111,共6页
针对红松虫害检测数据不准确、系统响应时间长、检测效果不理想的问题,这里基于TRIZ理论设计了一种采用图像识别检测、可蠕动攀爬树干的红松虫害检测机器人。通过需求分析,确定虫害检测机器人的动作流程和组成结构;应用最终理想解、技... 针对红松虫害检测数据不准确、系统响应时间长、检测效果不理想的问题,这里基于TRIZ理论设计了一种采用图像识别检测、可蠕动攀爬树干的红松虫害检测机器人。通过需求分析,确定虫害检测机器人的动作流程和组成结构;应用最终理想解、技术矛盾、物理矛盾、技术进化法则等TRIZ工具对移动机构、抱紧机构、检测机构进行创新设计,构建了红松虫害检测机器人的三维实体模型,应用ADAMS软件进行动态仿真,仿真结果表明攀爬运动过程符合设计要求。在产品概念设计阶段应用TRIZ理论,有利于产生高质量、多层级的概念解,提高产品设计效率。 展开更多
关键词 红松 虫害 检测机器人 蠕动 图像识别 概念设计 TRIZ(theory of Inventive Problem Solving)
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