为了提高槲皮素的生物利用度以改善其抗肿瘤等活性,本论文根据其体内基本传递特性,利用前药原理成功设计合成了3个新型槲皮素磺酸酯衍生物(1,3～4),所有化合物的结构均经IR,MS,元素分析和1 H NMR等确证。对目标产物进行溶解度测定,发现...为了提高槲皮素的生物利用度以改善其抗肿瘤等活性,本论文根据其体内基本传递特性,利用前药原理成功设计合成了3个新型槲皮素磺酸酯衍生物(1,3～4),所有化合物的结构均经IR,MS,元素分析和1 H NMR等确证。对目标产物进行溶解度测定,发现三种目标化合物的脂溶性与水溶性均有显著的提高。展开更多
3,5-di(2-pyrazinyl)-4-amino-1,2,4-triazole(II) was synthesized through hydrothermal reaction,and the crystal structure was determined by X-ray crystallography.Crystalline was assigned into triclinic system with space ...3,5-di(2-pyrazinyl)-4-amino-1,2,4-triazole(II) was synthesized through hydrothermal reaction,and the crystal structure was determined by X-ray crystallography.Crystalline was assigned into triclinic system with space group P-1,lattice parameters a=0.62527(2) nm,b=0.6807(2) nm,c=1.2792(4) nm,α=85.833(5)o,β=80.517(5)o,γ=72.405(5)°,V=0.5118(3) nm3,and Z=2.Intermolecular hydrogen bonds extend the molecules of compound(II) into a 2D supramolecular layer.CCDC:666956.展开更多
The new dithiocarbamate 4-vinylbenzyl 9H-carbazole-9-carbodithioate was synthesized and characterized by means of 1H NMR,elemental analysis,FT-IR,and X-ray crystallography.The crystal structure is of triclinic,space g...The new dithiocarbamate 4-vinylbenzyl 9H-carbazole-9-carbodithioate was synthesized and characterized by means of 1H NMR,elemental analysis,FT-IR,and X-ray crystallography.The crystal structure is of triclinic,space group Pī,with a=9.4301(19) nm,b=9.518(2) nm,c=10.541(2),α=83.909(16) °,β=77.279(13)°,γ=79.312(14) °,V=904.8(3) nm3,Z=2,F(000)=376,Dc=1.319 mg/ m3,final R1=0.0731,wR2=0.1615 for 10164 observed reflections with I> 2σ(I).The thermal stability of the title compound was also studied.The main released gas product of the thermal decomposition of the title compound were possibly nitrogen,carbon sulfide and hydrogen sulfide,and the final solid product was 14.5% carbon leavings.展开更多
A novel nickel(Ⅱ)complex[Ni(C22H34N6)](ClO4)2 had been synthesized and characterized by elementary analysis and signal-crystal X-ray diffraction analysis.The results showed that the complex crystallizes in a triclini...A novel nickel(Ⅱ)complex[Ni(C22H34N6)](ClO4)2 had been synthesized and characterized by elementary analysis and signal-crystal X-ray diffraction analysis.The results showed that the complex crystallizes in a triclinic system,the space group P1-with a=10.209(1),b=11.617(1),c=11.916(1),α=87.633(2),β=75.940(2)°,γ=88.501(2)°,V=1369.5(2)3,Z=2,F(000)=668,Dc=1.552g/cm3,R1=0.036,wR2=0.105.In the crystal there are two independent Ni(II)centres.Each Ni(II)ion is coordinated by four secondary nitrogen atoms from one macrocycle and two oxygen atoms from two perchlorate anions to form a distorted octahedron geometry.展开更多
A new borate [Ni(dien)2][B5O6(OH)4]2(1,dien = diethylenetriamine) has been hydrothermally synthesized and structurally characterized.The crystal structure of compound 1 crystallizes is of monoclinic system,space group...A new borate [Ni(dien)2][B5O6(OH)4]2(1,dien = diethylenetriamine) has been hydrothermally synthesized and structurally characterized.The crystal structure of compound 1 crystallizes is of monoclinic system,space group C2 with a= 14.498(3),b = 11.757(2),c= 8.5455(17),β= 90.93(3)o,V = 1456.4(5)3,Z= 2.Compound 1 consists of borate polyanion [B5O6(OH)4]-and complex cation [Ni(dien)2]2+.The anionic [B5O6(OH)4]-units are linked by O-H…O H-bonds to form a 3-D supramolecular network with 1-D large channels,where the [Ni(dien)2]2+ cation are located.The optical absorption spectrum indicates that compound 1 is wide-band-gap semiconductors.展开更多
文摘3,5-di(2-pyrazinyl)-4-amino-1,2,4-triazole(II) was synthesized through hydrothermal reaction,and the crystal structure was determined by X-ray crystallography.Crystalline was assigned into triclinic system with space group P-1,lattice parameters a=0.62527(2) nm,b=0.6807(2) nm,c=1.2792(4) nm,α=85.833(5)o,β=80.517(5)o,γ=72.405(5)°,V=0.5118(3) nm3,and Z=2.Intermolecular hydrogen bonds extend the molecules of compound(II) into a 2D supramolecular layer.CCDC:666956.
文摘The new dithiocarbamate 4-vinylbenzyl 9H-carbazole-9-carbodithioate was synthesized and characterized by means of 1H NMR,elemental analysis,FT-IR,and X-ray crystallography.The crystal structure is of triclinic,space group Pī,with a=9.4301(19) nm,b=9.518(2) nm,c=10.541(2),α=83.909(16) °,β=77.279(13)°,γ=79.312(14) °,V=904.8(3) nm3,Z=2,F(000)=376,Dc=1.319 mg/ m3,final R1=0.0731,wR2=0.1615 for 10164 observed reflections with I> 2σ(I).The thermal stability of the title compound was also studied.The main released gas product of the thermal decomposition of the title compound were possibly nitrogen,carbon sulfide and hydrogen sulfide,and the final solid product was 14.5% carbon leavings.
文摘A novel nickel(Ⅱ)complex[Ni(C22H34N6)](ClO4)2 had been synthesized and characterized by elementary analysis and signal-crystal X-ray diffraction analysis.The results showed that the complex crystallizes in a triclinic system,the space group P1-with a=10.209(1),b=11.617(1),c=11.916(1),α=87.633(2),β=75.940(2)°,γ=88.501(2)°,V=1369.5(2)3,Z=2,F(000)=668,Dc=1.552g/cm3,R1=0.036,wR2=0.105.In the crystal there are two independent Ni(II)centres.Each Ni(II)ion is coordinated by four secondary nitrogen atoms from one macrocycle and two oxygen atoms from two perchlorate anions to form a distorted octahedron geometry.
文摘A new borate [Ni(dien)2][B5O6(OH)4]2(1,dien = diethylenetriamine) has been hydrothermally synthesized and structurally characterized.The crystal structure of compound 1 crystallizes is of monoclinic system,space group C2 with a= 14.498(3),b = 11.757(2),c= 8.5455(17),β= 90.93(3)o,V = 1456.4(5)3,Z= 2.Compound 1 consists of borate polyanion [B5O6(OH)4]-and complex cation [Ni(dien)2]2+.The anionic [B5O6(OH)4]-units are linked by O-H…O H-bonds to form a 3-D supramolecular network with 1-D large channels,where the [Ni(dien)2]2+ cation are located.The optical absorption spectrum indicates that compound 1 is wide-band-gap semiconductors.
