Optical reflection anisotropy microscopy mappings of micropipe defects on the surface of a 4H-SiC single crystal are studied by the scanning anisotropy microscopy(SAM)system.The reflection anisotropy(RA)image with a&#...Optical reflection anisotropy microscopy mappings of micropipe defects on the surface of a 4H-SiC single crystal are studied by the scanning anisotropy microscopy(SAM)system.The reflection anisotropy(RA)image with a'butterfly pattern'is obtained around the micropipes by SAM.The RA image of the edge dislocations is theoretically simulated based on dislocation theory and the photoelastic principle.By comparing with the Raman spectrum,it is verified that the micropipes consist of edge dislocations.The different patterns of the RA images are due to the different orientations of the Burgers vectors.Besides,the strain distribution of the micropipes is also deduced.One can identify the dislocation type,the direction of the Burgers vector and the optical anisotropy from the RA image by using SAM.Therefore,SAM is an ideal tool to measure the optical anisotropy induced by the strain field around a defect.展开更多
In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-co...In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-consistent model. The simulation results predicted a constricted arc column and obvious anode phenomena in Cu–Cr alloy contacts than in W–Cu alloy contacts.This observation could be the reason for the concentrated anode erosion in Cu–Cr alloys. For the contacts made by pure tungsten(W) and W–Cu alloy, the anode temperature increased rapidly because of the low specific heat of W. However, the maximum energy flux from the arc column to the anode surface was lower than in other cases. The simulation results were compared with experimental results.展开更多
Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characteriz...Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to cirrhosis.The compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are rare.Therefore,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.展开更多
Roll motion of ships can be distinguished in two parts:an unavoidable part due to their natural movement while turning and an unwanted and avoidable part that is due to encounter with waves and rough seas in general.F...Roll motion of ships can be distinguished in two parts:an unavoidable part due to their natural movement while turning and an unwanted and avoidable part that is due to encounter with waves and rough seas in general.For the attenuation of the unwanted part of roll motion,ways have been developed such as addition of controllable fins and changes in shape.This paper investigates the effectiveness of augmenting the rudder used for rejecting part of the unwanted roll,while maintaining steering and course changing ability.For this purpose,a controller is designed,which acts through intentional superposition of fast,compared with course change,movements of rudder,in order to attenuate the high-frequency roll effects from encountering rough seas.The results obtained by simulation to exogenous disturbance support the conclusion that the roll stabilization for displacement can be effective at least when displacement hull vessels are considered.Moreover,robust stability and performance is verified for the proposed control scheme over the entire operating range of interest.展开更多
Aptamers as a kind of biological recognition element have shown great potential in monitoring and the rapid quantification of organophosphorus pesticides(OPPs). However, molecules of OPPs are structurally similar and ...Aptamers as a kind of biological recognition element have shown great potential in monitoring and the rapid quantification of organophosphorus pesticides(OPPs). However, molecules of OPPs are structurally similar and original aptamers selected by systematic evolution of ligands by exponential enrichment are usually long-chain bases, which hamper the further application under OPPs-aptamer recognition. The aim of the research was to develop a new strategy to design oligonucleotide sequences for binding OPPs by combination of experimental and molecular modeling methods. 3D models of aptamers binding OPPs were constructed, and binding energy and the most probable binding site for the OPPs were then determined by molecular docking, and the binding sites were further confirmed by the results of 2-AP replaced experiments. Based on the docking results, a new aptamer for detection 4 representative OPPs with only 29 bases was designed by reasonable truncation and mutation of the reported aptamer(named S4-29). The interaction between this new aptamer and OPPs were analyzed by molecular docking, microscale thermophoresis, circular dichroism and fluorometric analysis. The results revealed that the new aptamer exhibit more superior recognition performance to OPPs, which can be promote the monitoring ability of OPPs contaminations in food.展开更多
This paper reviewed the development of optically pumped GaSb based semiconductor disk lasers （SDLs） emission at 2 μm wavelength region from the aspects of wavelength extending, power scaling, line-width narrowing a...This paper reviewed the development of optically pumped GaSb based semiconductor disk lasers （SDLs） emission at 2 μm wavelength region from the aspects of wavelength extending, power scaling, line-width narrowing and short-pulse generation. Most recently, the wavelength of GaSb based SDLs has been extended to 2.8 μm. The highest output power of the GaSb based SDLs has been reached to 17 W at the temperature of 20 ℃. By using active stabilization, the GaSb based SDL with line-width of 20 kHz and output power of 1 W was realized. Moreover, the shortest pulse obtained fromthe GaSb based SDLs was generated as short as 384 fs by incorporating semiconductor saturable absorber mirrors（SESAM） in the cavity.展开更多
For mode selection in a quantum cascade laser(QCL),we demonstrate an anti-symmetric sampled grating(ASG).The wavelength of the-1-th mode of this laser has been blue-shifted more than 75 nm(~10 cm^(-1))compared with th...For mode selection in a quantum cascade laser(QCL),we demonstrate an anti-symmetric sampled grating(ASG).The wavelength of the-1-th mode of this laser has been blue-shifted more than 75 nm(~10 cm^(-1))compared with that of an ordinary sampled grating laser with an emission wavelength of approximately 8.6μm,when the periodicities within both the base grating and the sample grating are kept constant.Under this condition,an improvement in the continuous tuning capability of the QCL array is ensured.The ASG structure is fabricated in holographic exposure and optical photolithography,thereby enhancing its flexibility,repeatability,and cost-effectiveness.The wavelength modulation capability of the two channels of the grating is insensitive to the variations in channel size,assuming that the overall waveguide width remains constant.The output wavelength can be tailored freely within a certain range by adjusting the width of the ridge and the material of the cladding layer.展开更多
As the main source of the vacuum arc plasma,cathode spots(CSs)play an important role on the behaviors of the vacuum arc.Their characteristics are affected by many factors,especially by the magnetic field.In this paper...As the main source of the vacuum arc plasma,cathode spots(CSs)play an important role on the behaviors of the vacuum arc.Their characteristics are affected by many factors,especially by the magnetic field.In this paper,the characteristics of the plasma jet from a single CS in vacuum arc under external axial magnetic field(AMF)are studied.A multi-species magneto-hydro-dynamic(MHD)model is established to describe the vacuum arc.The anode temperature is calculated by the anode activity model based on the energy flux obtained from the MHD model.The simulation results indicate that the external AMF has a significant effect on the characteristic of the plasma jet.When the external AMF is high enough,a bright spot appears on the anode surface.This is because with a higher AMF,the contraction of the diffused arc becomes more obvious,leading to a higher energy flux to the anode and thus a higher anode temperature.Then more secondary plasma can be generated near the anode,and the brightness of the‘anode spot’increases.During this process,the arc appearance gradually changes from a cone to a dumbbell shape.In this condition,the arc is in the diffuse mode.The appearance of the plasma jet calculated in the model is consistent with the experimental results.展开更多
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2018YFE0204001,2018YFA0209103,2016YFB0400101,and 2016YFB0402303)the National Natural Science Foundation of China(Grant Nos.61627822,61704121,61991430,and 62074036)Postdoctoral Research Program of Jiangsu Province(Grant No.2021K599C).
文摘Optical reflection anisotropy microscopy mappings of micropipe defects on the surface of a 4H-SiC single crystal are studied by the scanning anisotropy microscopy(SAM)system.The reflection anisotropy(RA)image with a'butterfly pattern'is obtained around the micropipes by SAM.The RA image of the edge dislocations is theoretically simulated based on dislocation theory and the photoelastic principle.By comparing with the Raman spectrum,it is verified that the micropipes consist of edge dislocations.The different patterns of the RA images are due to the different orientations of the Burgers vectors.Besides,the strain distribution of the micropipes is also deduced.One can identify the dislocation type,the direction of the Burgers vector and the optical anisotropy from the RA image by using SAM.Therefore,SAM is an ideal tool to measure the optical anisotropy induced by the strain field around a defect.
基金supported by the Sichuan Science and Technology Program (No. 2024NSFSC0867)National Natural Science Foundation of China (No. 52377157)。
文摘In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-consistent model. The simulation results predicted a constricted arc column and obvious anode phenomena in Cu–Cr alloy contacts than in W–Cu alloy contacts.This observation could be the reason for the concentrated anode erosion in Cu–Cr alloys. For the contacts made by pure tungsten(W) and W–Cu alloy, the anode temperature increased rapidly because of the low specific heat of W. However, the maximum energy flux from the arc column to the anode surface was lower than in other cases. The simulation results were compared with experimental results.
基金supported by the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-007A)the China International Medical Foundation Project(Grant No.Z-2021-15-18)Tianjin Health Technology Project(Grant No.20188).
文摘Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to cirrhosis.The compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are rare.Therefore,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.
文摘Roll motion of ships can be distinguished in two parts:an unavoidable part due to their natural movement while turning and an unwanted and avoidable part that is due to encounter with waves and rough seas in general.For the attenuation of the unwanted part of roll motion,ways have been developed such as addition of controllable fins and changes in shape.This paper investigates the effectiveness of augmenting the rudder used for rejecting part of the unwanted roll,while maintaining steering and course changing ability.For this purpose,a controller is designed,which acts through intentional superposition of fast,compared with course change,movements of rudder,in order to attenuate the high-frequency roll effects from encountering rough seas.The results obtained by simulation to exogenous disturbance support the conclusion that the roll stabilization for displacement can be effective at least when displacement hull vessels are considered.Moreover,robust stability and performance is verified for the proposed control scheme over the entire operating range of interest.
基金supported by the National Natural Science Foundation of China (31801647)Sichuan Science and Technology Program (2018JY0194,2020YFN0153,2020YFN0151)。
文摘Aptamers as a kind of biological recognition element have shown great potential in monitoring and the rapid quantification of organophosphorus pesticides(OPPs). However, molecules of OPPs are structurally similar and original aptamers selected by systematic evolution of ligands by exponential enrichment are usually long-chain bases, which hamper the further application under OPPs-aptamer recognition. The aim of the research was to develop a new strategy to design oligonucleotide sequences for binding OPPs by combination of experimental and molecular modeling methods. 3D models of aptamers binding OPPs were constructed, and binding energy and the most probable binding site for the OPPs were then determined by molecular docking, and the binding sites were further confirmed by the results of 2-AP replaced experiments. Based on the docking results, a new aptamer for detection 4 representative OPPs with only 29 bases was designed by reasonable truncation and mutation of the reported aptamer(named S4-29). The interaction between this new aptamer and OPPs were analyzed by molecular docking, microscale thermophoresis, circular dichroism and fluorometric analysis. The results revealed that the new aptamer exhibit more superior recognition performance to OPPs, which can be promote the monitoring ability of OPPs contaminations in food.
基金We are grateful for financial supports from the Major Program of National Natural Science Foundation of China （61790584）.
文摘This paper reviewed the development of optically pumped GaSb based semiconductor disk lasers （SDLs） emission at 2 μm wavelength region from the aspects of wavelength extending, power scaling, line-width narrowing and short-pulse generation. Most recently, the wavelength of GaSb based SDLs has been extended to 2.8 μm. The highest output power of the GaSb based SDLs has been reached to 17 W at the temperature of 20 ℃. By using active stabilization, the GaSb based SDL with line-width of 20 kHz and output power of 1 W was realized. Moreover, the shortest pulse obtained fromthe GaSb based SDLs was generated as short as 384 fs by incorporating semiconductor saturable absorber mirrors（SESAM） in the cavity.
基金Project supported by the National Basic Research Program of China (Grant No. 2021YFB3201900)in part by the National Natural Science Foundation of China (Grant Nos. 61991430, 61774146, 61790583,61627822, and 61774150)in part by the Key Projects of the Chinese Academy of Sciences (Grant Nos. 2018147, YJKYYQ20190002, QYZDJ-SSW-JSC027,XDB43000000)
文摘For mode selection in a quantum cascade laser(QCL),we demonstrate an anti-symmetric sampled grating(ASG).The wavelength of the-1-th mode of this laser has been blue-shifted more than 75 nm(~10 cm^(-1))compared with that of an ordinary sampled grating laser with an emission wavelength of approximately 8.6μm,when the periodicities within both the base grating and the sample grating are kept constant.Under this condition,an improvement in the continuous tuning capability of the QCL array is ensured.The ASG structure is fabricated in holographic exposure and optical photolithography,thereby enhancing its flexibility,repeatability,and cost-effectiveness.The wavelength modulation capability of the two channels of the grating is insensitive to the variations in channel size,assuming that the overall waveguide width remains constant.The output wavelength can be tailored freely within a certain range by adjusting the width of the ridge and the material of the cladding layer.
基金supported by National Natural Science Foundation of China(Nos.U1866202 and 51877164)State Key Laboratory of Electrical Insulation and Power Equipment Fund(No.EIPE19128)。
文摘As the main source of the vacuum arc plasma,cathode spots(CSs)play an important role on the behaviors of the vacuum arc.Their characteristics are affected by many factors,especially by the magnetic field.In this paper,the characteristics of the plasma jet from a single CS in vacuum arc under external axial magnetic field(AMF)are studied.A multi-species magneto-hydro-dynamic(MHD)model is established to describe the vacuum arc.The anode temperature is calculated by the anode activity model based on the energy flux obtained from the MHD model.The simulation results indicate that the external AMF has a significant effect on the characteristic of the plasma jet.When the external AMF is high enough,a bright spot appears on the anode surface.This is because with a higher AMF,the contraction of the diffused arc becomes more obvious,leading to a higher energy flux to the anode and thus a higher anode temperature.Then more secondary plasma can be generated near the anode,and the brightness of the‘anode spot’increases.During this process,the arc appearance gradually changes from a cone to a dumbbell shape.In this condition,the arc is in the diffuse mode.The appearance of the plasma jet calculated in the model is consistent with the experimental results.
