摘要
Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to cirrhosis.The compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are rare.Therefore,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.
基金
supported by the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-007A)
the China International Medical Foundation Project(Grant No.Z-2021-15-18)
Tianjin Health Technology Project(Grant No.20188).
作者简介
Corresponding Authors:Songtao Shou,Email:stshou@qq.com;Corresponding Authors:Lijun Wang,Email:wanglijun211022@tmu.edu.cn。
