随着糖尿病和肺结核两大疾病发病率的升高，糖尿病并发耐药肺结核的患者越来越多，耐多药结核病（multidrug-resistant tuberculosis，MDR-TB）和广泛耐药结核病（extensively drug resistant tuberculosis，XDR-TB）的暴发对全球结核...随着糖尿病和肺结核两大疾病发病率的升高，糖尿病并发耐药肺结核的患者越来越多，耐多药结核病（multidrug-resistant tuberculosis，MDR-TB）和广泛耐药结核病（extensively drug resistant tuberculosis，XDR-TB）的暴发对全球结核病的控制提出严峻挑战。作者主要从糖尿病对耐药肺结核的发病率、临床特点、诊断和治疗、预后转归的影响，以及耐药肺结核对糖尿病的影响、作用机制等方面阐述两者之间的关系，为合理治疗糖尿病并发结核病提供理论依据，以改善此类患者的预后。展开更多
A novel chiral stationary phase(CSP) for HPLC was prepared by synthesizing 3,5-dinitrobenzoyl-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid as chiral selector and bonding it with 3-aminopropylsilane modified si...A novel chiral stationary phase(CSP) for HPLC was prepared by synthesizing 3,5-dinitrobenzoyl-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid as chiral selector and bonding it with 3-aminopropylsilane modified silica.The resolutions of 8 enantiomers of binaphthol and its derivatives were achieved by using hexane-ethanol-acetic acid(98∶2∶0.5,volume ratio) as mobile phase with a column temperature 30 ℃ and detected at ultraviolet 254 nm.The effects of acetic acid and alcohol organic modifiers on retention and resolutions of the analytes were examined.The enantioselectivities α of the analytes on CSP could be improved by adding acetic acid to mobile phase due to masking effect of H^+ on the residing silanol and amino group.展开更多
文摘随着糖尿病和肺结核两大疾病发病率的升高，糖尿病并发耐药肺结核的患者越来越多，耐多药结核病（multidrug-resistant tuberculosis，MDR-TB）和广泛耐药结核病（extensively drug resistant tuberculosis，XDR-TB）的暴发对全球结核病的控制提出严峻挑战。作者主要从糖尿病对耐药肺结核的发病率、临床特点、诊断和治疗、预后转归的影响，以及耐药肺结核对糖尿病的影响、作用机制等方面阐述两者之间的关系，为合理治疗糖尿病并发结核病提供理论依据，以改善此类患者的预后。
文摘A novel chiral stationary phase(CSP) for HPLC was prepared by synthesizing 3,5-dinitrobenzoyl-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid as chiral selector and bonding it with 3-aminopropylsilane modified silica.The resolutions of 8 enantiomers of binaphthol and its derivatives were achieved by using hexane-ethanol-acetic acid(98∶2∶0.5,volume ratio) as mobile phase with a column temperature 30 ℃ and detected at ultraviolet 254 nm.The effects of acetic acid and alcohol organic modifiers on retention and resolutions of the analytes were examined.The enantioselectivities α of the analytes on CSP could be improved by adding acetic acid to mobile phase due to masking effect of H^+ on the residing silanol and amino group.
