The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemica...The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemical characteristics from that of Morin in the presence of DNA. The results suggest that Morin and its complexes can both bind to DNA, but the binding mode is different. The complexes bind to DNA mainly like EB by intercalation, while Morin binds in a non-intercalating mode.展开更多
The compounds of O-(thiaxanthon-2-yl)-oxyacetate,was synthesized from 2,2’-Dithiosalicylic acid.The compound was identified by elemental analysis,IR,1H NMR,13CNMR spectrum.The effect of ratio of starting materias,tem...The compounds of O-(thiaxanthon-2-yl)-oxyacetate,was synthesized from 2,2’-Dithiosalicylic acid.The compound was identified by elemental analysis,IR,1H NMR,13CNMR spectrum.The effect of ratio of starting materias,temperature,time on yield were explored,and the synthetic condition was optimized by high efficiency liquid chromatography.This method is more suitable for the industrial production.展开更多
Binding of Δ , Λ [Ni(phen) 3] 2+ to calf thymus DNA was studied by circular dichroism and electrochemical methods. The selectivity of Δ isomer in binding to a right handed duplex of DNA was found. Binding constants...Binding of Δ , Λ [Ni(phen) 3] 2+ to calf thymus DNA was studied by circular dichroism and electrochemical methods. The selectivity of Δ isomer in binding to a right handed duplex of DNA was found. Binding constants and binding site sizes for Δ and Λ [Ni(phen) 3] 2+ with DNA were determined from voltammetric data.展开更多
文摘The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemical characteristics from that of Morin in the presence of DNA. The results suggest that Morin and its complexes can both bind to DNA, but the binding mode is different. The complexes bind to DNA mainly like EB by intercalation, while Morin binds in a non-intercalating mode.
文摘The compounds of O-(thiaxanthon-2-yl)-oxyacetate,was synthesized from 2,2’-Dithiosalicylic acid.The compound was identified by elemental analysis,IR,1H NMR,13CNMR spectrum.The effect of ratio of starting materias,temperature,time on yield were explored,and the synthetic condition was optimized by high efficiency liquid chromatography.This method is more suitable for the industrial production.
文摘Binding of Δ , Λ [Ni(phen) 3] 2+ to calf thymus DNA was studied by circular dichroism and electrochemical methods. The selectivity of Δ isomer in binding to a right handed duplex of DNA was found. Binding constants and binding site sizes for Δ and Λ [Ni(phen) 3] 2+ with DNA were determined from voltammetric data.
