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The taxonomic status of the Late Cretaceous dromaeosaurid Linheraptor exquisitus and its implications for dromaeosaurid systematics 被引量:2
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作者 XU Xing Michael PITTMAN +5 位作者 Corwin SULLIVAN Jonah N. CHOINIERE TAN Qing-Wei James M. CLARK Mark A. NORELL WANG Shuo 《古脊椎动物学报》 CSCD 北大核心 2015年第1期29-62,共34页
关键词 动物学 古脊椎动物学 研究 发展
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Theoretical analysis of a row of piles as passive barriers and an equivalent in-filled trench model
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作者 高广运 宋健 杨峻 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期1919-1928,共10页
A theoretical study on the ground vibration isolation efficiency by a row of piles as passive barrier in a three-dimensional context was presented. The analysis was accomplished with the aid of integral equations gove... A theoretical study on the ground vibration isolation efficiency by a row of piles as passive barrier in a three-dimensional context was presented. The analysis was accomplished with the aid of integral equations governing Rayleigh wave scattering, used to predict the complicated Rayleigh wave field generated by a number of irregular scatters embedded in an elastic half-space. Then, the passive isolation effectiveness of a row of piles for screening Rayleigh wave was studied in detail. The effects of relevant parameters on the screening effectiveness were investigated and analyzed from the perspective of equivalence with in-filled trench. The results show that using a row of rigid piles as wave barrier is more effective than that of flexible ones, and an optimum reduction of vibration can be achieved either by increasing the size of piles or by decreasing the net spacing between the piles. Finally, based on the derived integral equation for Rayleigh wave scattering, the principle of equivalent modeling of the barrier of piles by an in-filled trench is put forward, which simplifies the analysis of vibration isolation by a row of piles. 展开更多
关键词 Rayleigh wave scattering integral equation PILES in-filled trench ground vibration PASSIVE isolation equivalence principle
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Quantitative X-Ray Diffraction Technique for Evaluating the Stabilization of Hazardous Metals in Ceramic Products
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作者 SHIH Kaimin TANG Yuanyuan +1 位作者 LU Xingwen LIAO Changzhong 《矿物学报》 CAS CSCD 北大核心 2013年第S1期81-81,共1页
A sustainable waste management system requires the beneficial uses of waste residues, such as sludge and incineration ashes, generated from environmental treatments. Among the use strategies, the practices of mixing h... A sustainable waste management system requires the beneficial uses of waste residues, such as sludge and incineration ashes, generated from environmental treatments. Among the use strategies, the practices of mixing hazardous metal-bearing solids with clay materials to produce ceramic products are often found with significant improvement in reducing the metal leach ability from products. However, relatively much fewer studies have clearly answered the questions of "What are the metal stabilization mechanisms other than simply the dilution effect and the encapsulation of metals?"; "What are the mineral phases of metals and how much are they in the products?"; and "How thermal conditions can effetely promote the transformations of metal-hosting mineral phases?". As many sustainability movements have increasingly promoted the adoption of those products generated from the beneficial use of waste materials, quantitative understandings of the metal incorporation efficiencies are important to facilitate the design of safe and reliable waste-to-resource strategies. Current findings on the metal incorporation mechanisms between common alumino silicates and hazardous metals (nickel, copper, and zinc) under different thermal conditions will be presented, and the results show the important role of forming aluminates and ferrites to significantly reduce the metal leach ability from the products. In the study, the technique of quantitative X-ray diffraction (QXRD) was applied to report the metal incorporation efficiencies through a 3-hour sintering process, aiming to stabilize the hazardous metals and also to turn the waste residues for usable ceramic products. Prolonged leach tests for potential metal-containing phases were carried out in acidic environments to evaluate the durability of thermally treated products. Both aluminate and ferrite spinels proved superior for thermomobilization of hazardous metals. With the information reported, this study has identified the key mechanisms of stabilizing the hazardous metals when thermally treated with common ceramic raw materials, and also demonstrates the importance of quantitative understanding in the development of a safe waste-to-resource strategy. 展开更多
关键词 QXRD hazardous metal SPINEL LEACH ABILITY environmental
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As An“Unfinished Scheme”-- Detective Fiction and the Sinicization of Modernity,1896-1949
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作者 Yang Yi 《学术界》 CSSCI 北大核心 2016年第11期263-271,共9页
This paper,analyses how the Chinese writers borrowed the literary genre of detective fiction from the West,but also points out the"indigenous"features of the Chinese detective fiction during the late Qing an... This paper,analyses how the Chinese writers borrowed the literary genre of detective fiction from the West,but also points out the"indigenous"features of the Chinese detective fiction during the late Qing and early republic periods.Further,it examines why a few Chinese writers chose to reshape detective fiction-an imported literary genre-with these indigenous features.While earlier studies argue that the"old htterateurs"in modem China represented the conservative forces,I believe that these writers were in fact well aware of the impact of Western ideologies and intellectual trends on the Chinese society.Their preference of the indigenous,therefore,was not a bhnd choice but a conscious act of resistance.Unlike the"New Literature"writers'positive responses to Westem ideas,this group of writers treated Western ideas not as the way-to save the motherland.Rather,they viewed the"hegemony"of the empires with alarm,and resorted to a set of traditional Chinese cultural values for ways of precluding such hegemony.Their efforts of reshaping detective fiction by this means,I argue,sheds a new light on the cultural transformation of the Chinese society-and,more broadly,of the Asian societies-during this time.That is,such transformation figured not simply as the great triumph of the West over the Asian societies,but rather suggested a dynamic process of cultural collisions and re-creation. 展开更多
关键词 中国 社会思潮 文学作品 历史
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将错就“措”还是改“谐”归正?谐音对消费者广告评价的影响
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作者 周寿江 赵一晨 +1 位作者 张瑾瑜 康琪 《心理学报》 北大核心 2025年第2期331-348,共18页
谐音早已成为一种广泛使用的重要广告语言工具,但尚未有研究考察谐音对广告效果的影响。基于失谐理论,本文通过7个实验(N=2456),考察了谐音对广告评价的影响,以及其作用机制和边界条件。结果发现,谐音能够促使消费者产生更为积极的广告... 谐音早已成为一种广泛使用的重要广告语言工具,但尚未有研究考察谐音对广告效果的影响。基于失谐理论,本文通过7个实验(N=2456),考察了谐音对广告评价的影响,以及其作用机制和边界条件。结果发现,谐音能够促使消费者产生更为积极的广告评价,且这一影响藉由新颖性、有趣性的链式中介而实现。然而,谐音对广告评价的这一积极效应会受到消费者新颖性寻求水平、产品消费风险、广告诉求的调节。具体而言,当消费者的新颖性寻求水平较低,或者产品消费风险很高、广告突出权威性时,谐音对广告评价的这一影响会受到削弱。本文结论不仅丰富了谐音启动和失谐理论方面的研究,也为企业广告实践和营销沟通提供了行之有效的管理洞察。 展开更多
关键词 谐音 失谐 新颖性寻求 感知风险 广告诉求
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Role of street patterns in zone-based traffic safety analysis 被引量:6
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作者 郭强 裴欣 +1 位作者 姚丹亚 黄仕进 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第6期2416-2422,共7页
Although extensive analyses of road segments and intersections located in urban road networks have examined the role of many factors that contribute to the frequency and severity of crashes, the explicit relationship ... Although extensive analyses of road segments and intersections located in urban road networks have examined the role of many factors that contribute to the frequency and severity of crashes, the explicit relationship between street pattern characteristics and traffic safety remains underexplored. Based on a zone-based Hong Kong database, the Space Syntax was used to quantify the topological characteristics of street patterns and investigate the role of street patterns and zone-related factors in zone-based traffic safety analysis. A joint probability model was adopted to analyze crash frequency and severity in an integrated modeling framework and the maximum likelihood estimation method was used to estimate the parameters. In addition to the characteristics of street patterns, speed, road geometry, land-use patterns, and temporal factors were considered. The vehicle hours was also included as an exposure proxy in the model to make crash frequency predictions. The results indicate that the joint probability model can reveal the relationship between zone-based traffic safety and various other factors, and that street pattern characteristics play an important role in crash frequency prediction. 展开更多
关键词 street pattern Space Syntax joint probability model crash frequency crash severity
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Laboratory investigation on relationship between degree of saturation, B-value and P-wave velocity 被引量:4
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作者 GU Xiao-qiang YANG Jun HUANG Mao-song 《Journal of Central South University》 SCIE EI CAS 2013年第7期2001-2007,共7页
Laboratory tests were performed on Toyoura sand specimens to investigate the relationship between degree of saturation Sr, B-value and P-wave velocity Vp. Different types of pore water (de-aired water or tap water) ... Laboratory tests were performed on Toyoura sand specimens to investigate the relationship between degree of saturation Sr, B-value and P-wave velocity Vp. Different types of pore water (de-aired water or tap water) and pore gas (air or CO2) as well as different magnitudes of back pressure were used to achieve different Sr (or B-value). The measured relationship between B-value and Vp was not consistent with the theoretical prediction. The measurement shows that the Vp value in the specimen flushed with de-aired water is independent of B-value (or St) and is always around the one in fully saturated condition. However, the Vp value in the specimen flushed with tap water increases with B-value, but the shape of the relationship between Vp and B-value is quite different from the theoretical prediction. The possible explanation for the discrepancy between laboratory measurement and theoretical prediction lies in that the air exists in the water as air bubbles and therefore the pore fluid (air-water mixture) is heterogeneous instead of homogenous assumed in the theoretical prediction. 展开更多
关键词 degree of saturation B-VALUE P-wave velocity bender element
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Discovery of a geomorphological analog to Martian araneiforms in the Qaidam Basin,Tibetan Plateau
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作者 Shengxing Zhang Yiliang Li Wei Leng 《中国科学技术大学学报》 CAS 2024年第5期1-9,I0006,共10页
Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2)ice was proposed as an explanation for their form... Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2)ice was proposed as an explanation for their formation,which cannot occur on Earth due to the high climatic temperature.In this study,we propose an alternative mechanism that attrib-utes the araneiform formation to the erosion of upwelling salt water from the subsurface,relying on the identification of the first terrestrial analog found in a playa of the Qaidam Basin on the northern Tibetan Plateau.Morphological analysis indicates that the structures in the Qaidam Basin have fractal features comparable to araneiforms on Mars.A numerical model is developed to investigate the araneiform formation driven by the water-diffusion mechanism.The simulation res-ults indicate that the water-diffusion process,under varying ground conditions,may be responsible for the diverse aranei-form morphologies observed on both Earth and Mars.Our numerical simulations also demonstrate that the orientations of the saltwater diffusion networks are controlled by pre-existing polygonal cracks,which is consistent with observations of araneiforms on Mars and Earth.Our study thus suggests that a saltwater-related origin of the araneiform is possible and has significant implications for water searches on Mars. 展开更多
关键词 araneiform landform subsurface water Qaidam Basin Mars analog fractal simulations
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On Eigen-Matrix Translation Method for Classification of Biological Data
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作者 JIANG Hao QIU Yushan +1 位作者 CHENG Xiaoqing CHING Waiki 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第5期1212-1230,共19页
Driven by the challenge of integrating large amount of experimental data, classification technique emerges as one of the major and popular tools in computational biology and bioinformatics research. Machine learning m... Driven by the challenge of integrating large amount of experimental data, classification technique emerges as one of the major and popular tools in computational biology and bioinformatics research. Machine learning methods, especially kernel methods with Support Vector Machines (SVMs) are very popular and effective tools. In the perspective of kernel matrix, a technique namely Eigen- matrix translation has been introduced for protein data classification. The Eigen-matrix translation strategy has a lot of nice properties which deserve more exploration. This paper investigates the major role of Eigen-matrix translation in classification. The authors propose that its importance lies in the dimension reduction of predictor attributes within the data set. This is very important when the dimension of features is huge. The authors show by numerical experiments on real biological data sets that the proposed framework is crucial and effective in improving classification accuracy. This can therefore serve as a novel perspective for future research in dimension reduction problems. 展开更多
关键词 CLASSIFICATION dimension reduction eigen-matrix translation glycan data kernel method(KM) support vector machine (SVM)
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Transforming Role of Rehabilitation Psychologists: New Paradigm Challenges, and Directions
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作者 June LY Tang Tatia MC Lee 《中国康复医学杂志》 CAS CSCD 北大核心 2010年第4期293-300,共8页
Rehabilitation is an integrated program of interventions that support individuals with disabilities and chronic health conditions to attain 'personally fulfilling, socially meaningful,
关键词 《中国康复医学杂志》 期刊 编辑部 读者
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Vibration Analysis of Beams by Spline Finite Element
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作者 杨浩 《沈阳建筑大学学报(自然科学版)》 CAS 北大核心 2011年第6期1005-1012,共8页
In this paper,the spline finite element method is developed to investigate free vibration problems of beams.The cubic B-spline functions are used to construct the displacement field.The assembly of elements and the in... In this paper,the spline finite element method is developed to investigate free vibration problems of beams.The cubic B-spline functions are used to construct the displacement field.The assembly of elements and the introduction of boundary conditions follow the standard finite element procedure.The results under various boundary conditions are compared with those obtained by the exact method and the finite difference method.It shows that the results are in excellent agreement with the analytical results and much more accurate than the results obtained by the finite difference method,especially for higher order modes. 展开更多
关键词 vibration analysis BEAM SPLINE finite element method
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Review on the Methods for the Ground Improvement
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作者 ZHANG Lizhou DENG Xiangbo +1 位作者 XIE Yuxia WANG Kun 《机床与液压》 北大核心 2013年第18期1-6,共6页
Due to the extensive development in urban areas,the problematic ground has to be utilized for construction and activities. Thus,the methodologies for the ground improvement are extremely significant for the recycling ... Due to the extensive development in urban areas,the problematic ground has to be utilized for construction and activities. Thus,the methodologies for the ground improvement are extremely significant for the recycling of the problematic land. The appropriate methods can not only provide the effectiveness of ground treatment but also reduce the extra cost and labor for the future. In this paper,the common methods for the ground improvement will be presented and the ideas for the selection of such methods will be discussed as well. 展开更多
关键词 金属 压力加工 机床 液压技术
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基于多参数成像AFM的细胞及分子力学特性探测研究进展 被引量:8
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作者 李密 席宁 +1 位作者 王越超 刘连庆 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2018年第11期1106-1114,共9页
原子力显微镜(AFM)的发明为微纳尺度下高分辨率探测天然状态生物样本的物理特性提供了强大工具,是对传统生化特性检测方法的有力补充.近年来,多参数成像模式AFM的出现使得人们不仅可以获取生物样本表面形貌特征,还能同时获取生物样本多... 原子力显微镜(AFM)的发明为微纳尺度下高分辨率探测天然状态生物样本的物理特性提供了强大工具,是对传统生化特性检测方法的有力补充.近年来,多参数成像模式AFM的出现使得人们不仅可以获取生物样本表面形貌特征,还能同时获取生物样本多种力学特性图(如杨氏模量、黏附力、形变等),为研究生物结构、力学特性及其生理功能之间的关联提供了新的技术手段.多参数成像AFM的生物医学应用研究为细胞/分子生理活动及相关疾病内在机理带来了大量新的认识.本文结合作者在AFM细胞探测方面的研究工作,介绍了多参数成像AFM工作原理,总结了多参数成像AFM在细胞及分子力学特性探测方面的研究进展,并对其存在的问题进行了讨论和展望. 展开更多
关键词 原子力显微镜 多参数成像 力学特性 细胞 分子
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大别造山带碧溪岭橄榄岩中锆石U-Pb年龄和Hf同位素研究 被引量:4
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作者 郑建平 孙敏 +3 位作者 Griffin WL 钟增球 汤华云 张志海 《岩石学报》 SCIE EI CAS CSCD 北大核心 2007年第2期343-350,共8页
在详细形态和内部结构研究基础上,对碧溪岭橄榄岩锆石进行了配套的U-Pb年龄和Hf同位素分析。碧溪岭橄榄岩锆石主体是变质成因的,但有少量岩浆锆石残留。这些锆石主体给出了220~210Ma的变质生长/重结晶作用年龄;一颗具较高Th/U比值的锆... 在详细形态和内部结构研究基础上,对碧溪岭橄榄岩锆石进行了配套的U-Pb年龄和Hf同位素分析。碧溪岭橄榄岩锆石主体是变质成因的,但有少量岩浆锆石残留。这些锆石主体给出了220~210Ma的变质生长/重结晶作用年龄;一颗具较高Th/U比值的锆石给出646Ma的近协和年龄,限定了早期岩浆结晶作用的最小年龄。真正的侵位年龄可以由745Ma的上交点年龄来限定;210~222Ma则记录着深俯冲陆壳折返过程中的锆石生长。除少数颗粒的ε_(Hf)为负值外(-2.9),大部分锆石的ε_(Hf)是正的(高达+8.1)并具新元古代的亏损地幔模式年龄(0.6~1.0Ga,平均0.8Ga)。这些结果说明碧溪岭橄榄岩的初始物质是扬子大陆岩石圈内新元古代岩浆堆积作用产物。这样的岩浆堆积物来源于亏损的软流圈地幔,侵入于扬子的深部地壳之中(如底侵)并部分混染了古老地壳组分。它们随扬子向华北之下深俯冲碰撞和造山带折返过程中经历着复杂的变质改造作用。 展开更多
关键词 橄榄岩锆石 年龄和Hf同位素 新元古代底侵 扬子地块 早中生代折返 大别造山带 碧溪岭
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病人满意度的调查与评价 被引量:64
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作者 陈平雁 黄浙明 《中国医院管理》 1999年第7期19-22,共4页
对病人满意度调查与评价过程中研究对象的选择、样本容量、问卷设计、调查的实施方法、问卷的评价等方面存在的常见问题进行了综述。
关键词 病人满意度 样本容量 医院管理 调查
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扫描电镜评价MTAD对根尖区管间峡部感染物的清除效果 被引量:5
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作者 包旭东 姚娜 +2 位作者 郭惠杰 张成飞 岳林 《北京大学学报(医学版)》 CAS CSCD 北大核心 2012年第1期34-38,共5页
目的:评价MTAD根管冲洗剂清除根尖区峡部感染物的效果。方法:收集有管间峡部结构的上颌第一前磨牙15颗,建立粪肠球菌感染根管模型,分为5组,每组3颗。第1组不做根管预备,作为粪肠球菌感染状态的基线对照,其余4组采用Protaper旋转镍钛锉... 目的:评价MTAD根管冲洗剂清除根尖区峡部感染物的效果。方法:收集有管间峡部结构的上颌第一前磨牙15颗,建立粪肠球菌感染根管模型,分为5组,每组3颗。第1组不做根管预备,作为粪肠球菌感染状态的基线对照,其余4组采用Protaper旋转镍钛锉进行根管机械预备,冲洗分别用生理盐水、MTAD、次氯酸钠和次氯酸钠+EDTA。根管预备后制备扫描电镜标本,观察管间峡部表面细菌群落和玷污层的状态。结果:生理盐水组峡部表面厚层玷污层中嵌有大量细菌,玷污层评分中位数为5;MTAD组峡部表面也铺有玷污层,但玷污层评分较小,中位数为3,嵌入其中的细菌有破壁现象;次氯酸钠组峡部表面铺满牙本质泥,中位数也为5,但不含细菌;次氯酸钠+EDTA组峡部表面干净,牙本质小管和管间结构清晰,玷污层评分的中位数最小为1。结论:MTAD可渗入根尖区管间峡部,部分去除玷污层,但杀菌效果较弱;次氯酸钠配合EDTA冲洗可有效清除管间峡部的感染。 展开更多
关键词 根尖周炎 根管冲洗剂 肠球菌 次氯酸钠
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综合医院住院病人满意度量表研制初报 被引量:156
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作者 陈平雁 Chit-Ming Wong +4 位作者 区燕萍 胡静 张超 梁丽萍 蔡湛宇 《中国医院管理》 1999年第2期15-18,共4页
为客观地以服务对象为主体评价综合医院的医疗服务质量,本研究初步研制了住院病人满意度量表(IPSO),通过预调查数据,对量表作为一种测量工具进行了较系统的科学评价,以广州市3所综合医院的900例出院病人为调查对象,采用信函调查方式,初... 为客观地以服务对象为主体评价综合医院的医疗服务质量,本研究初步研制了住院病人满意度量表(IPSO),通过预调查数据,对量表作为一种测量工具进行了较系统的科学评价,以广州市3所综合医院的900例出院病人为调查对象,采用信函调查方式,初测有效回收率为30%,再测有效回收率为47%,项目应答率为93.2%。内部一致性α信度系数颇高,为0.92;初测与再测之间无显著性差异(P=0.183),且密切相关(r=0.812,P<0.0001),重测信度满意。经因予分析,因予负荷和结构与量表内容基本吻合,支持内容效度。因素内相关性强于因素间相关性的结果,有力地支持聚集和区分效度,可以初步认为,IPSO是可信的和有效的。 展开更多
关键词 病人满意度 量表 医院管理 服务质量
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GIS支持下的黄河河源区降水径流要素变化分析 被引量:17
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作者 李道峰 田英 刘昌明 《水土保持研究》 CSCD 2004年第1期144-147,155,共5页
对黄河河源区多年平均和雨季降水量、年际径流量进行分析。流域西北部玛多站多年平均降水量变化不大,而流域东南部降水丰沛的久治站则呈现大幅下降的趋势,这对黄河河源区的产流量带来不利的影响。年内降水量以雨季变化较大,且表现出下... 对黄河河源区多年平均和雨季降水量、年际径流量进行分析。流域西北部玛多站多年平均降水量变化不大,而流域东南部降水丰沛的久治站则呈现大幅下降的趋势,这对黄河河源区的产流量带来不利的影响。年内降水量以雨季变化较大,且表现出下降的趋势。计算得到径流量的变差系数、年际变化绝对比率和不均匀系数,表明径流量年际波动较大。认为降水强度和降水量是影响黄河河源区径流系数变化的主要原因。 展开更多
关键词 黄河河源区 降水量 径流 径流系数 GIS
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基于NDVI数据的黄河流域地表植被覆盖综合分类研究 被引量:17
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作者 李道峰 田英 郝芳华 《水土保持研究》 CSCD 2003年第4期88-91,共4页
在地理信息系统支持下,文章以时间分辨率为植物一个完整生长周期、空间分辨率1km×1km的NOAA/AVHRR遥感影像的NDVI指标为数据源,采用目前较为流行的主成分变换法,结合气象资料和数字高程模型(DEM),参考相关的地理基础图件,对黄河流... 在地理信息系统支持下,文章以时间分辨率为植物一个完整生长周期、空间分辨率1km×1km的NOAA/AVHRR遥感影像的NDVI指标为数据源,采用目前较为流行的主成分变换法,结合气象资料和数字高程模型(DEM),参考相关的地理基础图件,对黄河流域地表植被覆盖的进行综合分类。与传统对单一NOAA/AVHRR图像NDVI数据进行分类的方法相比,综合分类方法获得了较高的分类精度,取得了较好的效果。 展开更多
关键词 黄河流域 地表植被覆盖 NDVI 主成分变换
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EGFR突变与非小细胞肺癌酪氨酸激酶抑制剂靶向治疗 被引量:11
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作者 朱红 Tam Yee San Issan Maria Wong 《中国肿瘤生物治疗杂志》 CAS CSCD 2007年第2期105-109,共5页
肺癌的高发病率和高病死率,以及化疗对晚期肺癌疗效的十分有限,使之成为世界性医学难题。最近发现,表皮生长因子受体(epidermal growth factor receptor,EGFR)酪氨酸激酶抑制剂(tyrosine kinases inhibitors,TKIs)的分子靶向治疗可以使... 肺癌的高发病率和高病死率,以及化疗对晚期肺癌疗效的十分有限,使之成为世界性医学难题。最近发现,表皮生长因子受体(epidermal growth factor receptor,EGFR)酪氨酸激酶抑制剂(tyrosine kinases inhibitors,TKIs)的分子靶向治疗可以使晚期非小细胞肺癌瘤体缩小;然而,以Gefitinib和Erlotinib为代表的TKIs治疗敏感性与EGFR基因突变显著相关。研究证实,EGFR最常见发生的19区缺失突变和21区点突变导致相应氨基酸序列和EGFR结构的改变,是其增加药物敏感性的主要机制。此外,EGFR基因扩增和CA重复序列的多态性、EGFR通路下游信号(如p-AKT等)激活、HER2和(或)HER3表达的增加、K-RAS基因突变等因素皆影响其对TKIs的治疗敏感性。鉴于此,进一步研究EGFR基因不同突变的功能,寻找能预测TKIs治疗敏感性的因素,并作为TKIs敏感患者的筛选指标,对于提高晚期肺癌患者TKIs靶向治疗疗效具有重要意义。 展开更多
关键词 表皮生长因子受体 非小细胞肺癌 靶向治疗 酪氨酸激酶抑制剂
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