摘要
目的评价托拉塞米联合人血白蛋白治疗肝硬化腹水的临床疗效。方法选择2014年8月至2016年3月怀集县人民医院收治的70例肝硬化腹水患者作为研究对象,进行回顾性病例对照研究。按接受治疗方法不同分成观察组和对照组,每组35例。在常规治疗的基础上,观察组患者予托拉塞米联合人血白蛋白治疗,对照组患者仅予托拉塞米治疗,两组患者疗程均为1周。对比观察两组患者治疗中腹胀缓解时间、腹水减退时间和每日尿量,以及治疗后血清Na+和K+浓度的差异。结果观察组患者腹胀缓解时间[(3.1±1.5)d]及腹水减退时间[(4.2±1.8)d]均少于对照组患者[(4.5±1.3)d,(6.1±2.3)d],差异有统计学意义(P均<0.05)。观察组患者每日平均尿量[(2 137.4±252.6)m L]多于对照组患者[(1 529.6±217.3)m L],差异有统计学意义(P<0.05)。两组患者间比较,治疗后血清Na+和K+浓度差异无统计学意义(P均>0.05)。结论托拉塞米和人血白蛋白联合应用治疗肝硬化腹水能够起到协同增效的作用,提高临床治疗效果,可在临床进一步推广。
Objective To evaluate the clinical curative effect of torasemide plus human blood albumin for the treatment of cirrhosis ascites.Methods Atotal of 70 cases of patients with liver cirrhosis ascites were selected as the research objects that were treated between August 2014 and March 2014 in Huaiji County People’s Hospital,and a retrospective case-control study was carried out.Cases were chosen according to the single and double number methods and divided into observation group and control group, each group of 35 cases.On the basis of routine therapy,observation group of patients were treated with torasemide joint human blood albumin,and control group patients with torasemide only,for 1 week. Abdominal distension relief time,ascites and daily urine output,and serum Na + and K + concentration difference after treatment were observed in the patients between the two groups.Results The abdominal distension relief time [d](3.1 -1.5)and ascites decreased time [(4.2 +1.8)d]in the observation group were less than the control group patients [(4.5 +1.3)d,(6.1 +2.3)d],with statistically significant difference (all P <0.05).Observation group of patients had more average daily urine output [(2137.4 +252.6)mL]than the control group patients [(1 529.6 +217.3 )mL],with statistically significant difference (P <0.05 ).After comparison between the two groups of patients,serum Na + and K +concentration had no statistically significant difference (P >0.05).Conclusion Joint use of torasemide and blood albumin for treatment of liver cirrhosis ascites can have the effect of synergies and improve the efficacy of clinical treatment,but further popularization and clinical application are needed.
出处
《中华卫生应急电子杂志》
2016年第5期-,共3页
Chinese Journal of Hygiene Rescue(Electronic Edition)
关键词
肝硬化腹水
托拉塞米
人血白蛋白
Liver cirrhosis ascites
Torasemide
Human blood albumin
