摘要
目的 :评价硫酸镁联合硝苯地平治疗妊娠期高血压疾病的临床疗效。方法 :将我院于2014年2月~2016年4月收治的240例妊娠期高血压患者纳入研究,按照随机数表法分组。单用组120例,行静脉滴注硫酸镁治疗;联合组120例,行静脉滴注硫酸镁+口服硝苯地平治疗。观察两组患者治疗前、治疗7d后血压[收缩压(SBP)、舒张压(DBP)]水平变化,比较两组临床检测指标及分娩方式、妊娠结局,并评价其临床疗效。结果 :联合组治疗总有效率较单用组高[95.00%(114/120)vs 81.67%(98/120)],差异有统计学意义;两组治疗后SBP、DBP水平较治疗前均降低,且联合组降低幅度较大,差异有统计学意义;联合组治疗后尿酸、血尿素氮及血肌酐水平较单用组降低,差异有统计学意义;联合组自然分娩率较单用组高[60.83%(73/120)VS 46.67%(56/120)],异常妊娠结局率较单用组低[2.50%(3/120)vs 15.00%(18/120)],差异有统计学意义。结论 :给予妊娠期高血压患者硫酸镁联合硝苯地平治疗疗效确切,有助于降低血压水平,保护肾功能,减轻临床症状、体征,保障安全分娩,降低剖宫产率。
Objective To evaluate the clinical efficacy of magnesium sulfate combined with nifedipine in the treatment of hypertensive disorder complicating pregnancy. Methods 240 cases of hypertensive patients admitted to our hospital from February 2014 to April 2016 were included in the study and grouped according to the random number table method.120 cases of single group, intravenous infusion of magnesium sulfate treatment; combined group of 120 cases, intravenous infusion of magnesium sulfate + oral nifedipine treatment. The levels of systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured before and after treatment for 7 days. The clinical outcome of the two groups was compared with those of the two groups. Results The total effective rate of combined group was significantly higher than that of single group(95.00%(114/120) vs 81.67%(98/120) ], the difference was statistically significant; The levels of SBP and DBP in the two groups were lower than those before treatment, and the difference was statistically significant. The levels of uric acid, blood urea nitrogen and serum creatinine in the combined group were significantly lower than those in the control group. The rate of natural delivery was higher than that of single group [60.83%(73/120) vs 46.67%(56/120) ], and the outcome of abnormal pregnancy was lower than that of single group [2.50%(3/120) vs 15.00%(18/120) ], the difference was statistically significant. Conclusion The treatment effect of magnesium sulfate combined with nifedipine in pregnant women with hypertensive disorder is helpful to reduce blood pressure, protect renal function, reduce clinical symptoms and signs, and ensure safe delivery and reduce cesarean section rate.
出处
《湖南师范大学学报（医学版）》
2018年第4期135-137,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
妊娠期高血压
硫酸镁
硝苯地平
临床疗效
分娩结局
hypertension of pregnancy
magnesium sulfate
nifedipine
clinical efficacy
delivery outcome
