摘要
The heavy use of chemicals, pesticides, cosmetics and plastic packaging coincides with a resurgence of cardiovascular disease, in particular hypertension, which is affecting younger and younger populations. The aim of this study was to analyze the cardiovascular risk factors in hypertensive farmers compared with hypertensive non farmers. This was a prospective case-control study that included 239 hypertensive farmers and non farmers aged 25 to 65 with blood pressure ≥ 140 mmHg and 90 mmHg. Hypertensive farmers (101) represented 42.25% of the population versus hypertensive non farmers (138) 57.74%. The median ages were 47 ± 11.3 years for farmers and 51.45 ± 9.77 years for non farmers. Biochemical analysisand screening for major cardiovascular disease risk factors such as metabolic syndrome were performed. Metabolic syndrome was defined according to the new definition of the International Diabetes Federation. Our results revealed higher blood glucose levels in farmers (47.77%) than in non farmers (27.20%) (p = 0.0132). Dyslipidemia was more frequent in non farmerswith high level of LDL cholesterol and total cholesterol. Farmers presented a high level of tryglycerides. The prevalence of obesity was higher in non farmers 51 (36.96%) than farmers 18 (17.82%). The prevalence of metabolic syndrome was 106 (44.35%) in our study population. There was not an important difference between farmers (39.60%) and non farmers (47.82%). However, the variation of metabolic syndrome according to age and sex showed a higher prevalence in young male farmers aged 25 to 45 whereas non farmers presented an increasing prevalence of metabolic syndrome according to age and the absence of metabolic syndrome between age 25 and 35. Our results showed that the cardiovascular risk appeared early in young farmers compared with non farmers suggesting a possible role of pesticides in the onset of this risk.
The heavy use of chemicals, pesticides, cosmetics and plastic packaging coincides with a resurgence of cardiovascular disease, in particular hypertension, which is affecting younger and younger populations. The aim of this study was to analyze the cardiovascular risk factors in hypertensive farmers compared with hypertensive non farmers. This was a prospective case-control study that included 239 hypertensive farmers and non farmers aged 25 to 65 with blood pressure ≥ 140 mmHg and 90 mmHg. Hypertensive farmers (101) represented 42.25% of the population versus hypertensive non farmers (138) 57.74%. The median ages were 47 ± 11.3 years for farmers and 51.45 ± 9.77 years for non farmers. Biochemical analysisand screening for major cardiovascular disease risk factors such as metabolic syndrome were performed. Metabolic syndrome was defined according to the new definition of the International Diabetes Federation. Our results revealed higher blood glucose levels in farmers (47.77%) than in non farmers (27.20%) (p = 0.0132). Dyslipidemia was more frequent in non farmerswith high level of LDL cholesterol and total cholesterol. Farmers presented a high level of tryglycerides. The prevalence of obesity was higher in non farmers 51 (36.96%) than farmers 18 (17.82%). The prevalence of metabolic syndrome was 106 (44.35%) in our study population. There was not an important difference between farmers (39.60%) and non farmers (47.82%). However, the variation of metabolic syndrome according to age and sex showed a higher prevalence in young male farmers aged 25 to 45 whereas non farmers presented an increasing prevalence of metabolic syndrome according to age and the absence of metabolic syndrome between age 25 and 35. Our results showed that the cardiovascular risk appeared early in young farmers compared with non farmers suggesting a possible role of pesticides in the onset of this risk.
作者
Fidele Sonounameto
Marcelin Agbo
Colette Azandjeme
Santorin Seton
Mansouratou Betira
Jean-Baptiste Amagbegnon
Fresnel Cachon
Maximin Senou
Casmir Akpovi
Alphonse Sezan
Camille Dossou
Lamine Baba-Moussa
Joachim Gbenou
Omedine Koukoui
Fidele Sonounameto;Marcelin Agbo;Colette Azandjeme;Santorin Seton;Mansouratou Betira;Jean-Baptiste Amagbegnon;Fresnel Cachon;Maximin Senou;Casmir Akpovi;Alphonse Sezan;Camille Dossou;Lamine Baba-Moussa;Joachim Gbenou;Omedine Koukoui(Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP), Research Unit of Animal Physiology, Cell Signaling and Pharmacology (U-PASCPharm), ENSBBA/UNSTIM, Dassa-Zoumé, Benin;Department of Health Promotion, IRSP/UAC, Ouidah, Benin;Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP), Unit of Experimental and Clinical Biology (U-BEC), ENSBBA/UNSTIM, Dassa-Zoumé, Benin;Laboratory of Applied Biology Research, Research Unit on Non-Communicable Diseases and Cancer, EPAC/UAC, Cotonou, Benin;Laboratory of Pharmacology and Improved Traditional Medicines, Department of Animal Physiology, FAST/UAC, Cotonou, Benin;Laboratory of Molecular Biology and Typing in Microbiology, Department of Biochemistry and Cell Biology, FAST/UAC, Abomey Calavi, Benin;Laboratory of Pharmacognosy and Essential Oils, FAST/UAC, Cotonou, Benin)
