摘要
EBV相关胃癌(EBV-associated gastric carcinoma, EBVaGC)是常见的 EBV相关肿瘤之一,是胃癌(Gastric carcinoma, GC)独特亚型之一,约占GC的10%。EBVaGC的分子特征主要为DNA高甲基化、PIK3CA基因突变、PD-L1高表达及其他分子特征,这些分子特征不仅有助于EBVaGC的诊断和分类,而且为针对性的治疗提供了重要信息。由于这些分子特征,越来越多的研究开始关注靶向治疗在EBVaGC中的作用。本文就EBVaGC潜在治疗靶点的研究进展进行综述。EBV-associated gastric carcinoma (EBVaGC) is one of the common EBV-associated tumours and is one of the unique subtypes of gastric carcinoma (GC), accounting for about 10% of GC. The molecular features of EBVaGC are mainly DNA hypermethylation, PIK3CA gene mutation, high PD-L1 expression and other molecular features, which not only help to diagnose and classify EBVaGC, but also provide important information for targeted treatment. Due to these molecular features, more and more studies have begun to focus on the role of targeted therapy in EBVaGC. In this article, we review the research progress on potential therapeutic targets of EBVaGC.
出处
《临床个性化医学》
2024年第4期1697-1706,共10页
Journal of Clinical Personalized Medicine
