摘要
神经退行性疾病(Neurodegenerative disease)是一类以神经元变性病变为基础的缓慢进展性疾病的总称,主要包括阿尔茨海默病(Alzheimer’s disease, AD)、帕金森病(Parkinson’s disease, PD)及肌萎缩侧索硬化症(amyotrophic lateral sclerosis, ALS)等。最近的研究发现内源性大麻素系统(endocannabinoid system, eCBs)可能是一种保护神经元免受伤害性刺激的内源性系统,对神经退行性疾病的病程有预防治疗作用。本文综述了eCBs对AD、PD及ALS的保护作用的几个方面,旨在为神经退行性疾病的治疗开辟新的策略和思路。
Neurodegenerative diseases are characterized by slowly progressive degeneration and/or death of nerve cells. Examples of neurodegenerative diseases contain Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Recent studies reveal that endocannabinoid system may be an endogenous system that protects neurons from harmful stimuli and may have a preventive and therapeutic effect on the neurodegenerative diseases. Here we summarized several aspects of the eCBs protective effect of the AD, PD and ALS, aiming at providing promising thera-peutic targets and new strategy for neurodegenerative diseases.
出处
《国际神经精神科学杂志》
2020年第2期20-25,共6页
International Journal of Psychiatry and Neurology
