摘要
变应性鼻炎(AR)是耳鼻喉科的常见疾病,其发病机制是以IgE介导的I型变态反应为主,主要与Th1/Th2免疫炎症因子失衡有关。近年研究发现微小核糖核酸microRNA (miRNA)在AR的发病过程中起着重要的调控作用。目前大量研究证实miRNA与变应性疾病有密切的关系,该文就miRNA在变应性鼻炎发病过程中的研究进行广泛整理作一综述,以期为临床变应性鼻炎治疗及预防提供借鉴与参考,希望为后续探索miRNA在AR中的研究提供参考。Allergic rhinitis (AR) is a common disease in otorhinolaryngology. Its pathogenesis is mainly IgE-mediated type I allergic reaction, which is mainly related to the imbalance of Th1/Th2 immune inflammatory factors. Recent studies have found that microRNA (miRNA) plays an important regulatory role in the pathogenesis of AR. At present, a large number of studies have confirmed that miRNA is closely related to allergic diseases. This article reviews the research on miRNA in the pathogenesis of allergic rhinitis, in order to provide reference for the treatment and prevention of clinical allergic rhinitis, hoping to provide reference for the follow-up study of miRNA in AR.
出处
《临床医学进展》
2024年第11期554-560,共7页
Advances in Clinical Medicine
