摘要
急性髓系白血病(AML)是一种细胞遗传学和分子异质性疾病,其特征是克隆性髓系前体细胞的分化停滞和恶性增殖。尽管治疗选择越来越多,但大多数患者在缓解后仍会复发和死亡,预后仍然不理想。因此,有必要探索新的治疗方法。研究发现非编码RNA (ncRNA),特别是微RNA (miRNA)、长链非编码RNA (lncRNA)和环状RNA (circRNA)被发现与AML的发生发展、预后及耐药有关。本文重点介绍ncRNA与AML的相关性的最新研究结果,为未来AML开发高度特异性的诊断工具和更强大的治疗策略奠定基础。
Acute myeloid leukemia (AML) is a cytogenetic and molecular heterogeneous disease characterized by the arrest of differentiation and malignant proliferation of clonal myeloid precursors. Despite the increasing number of treatment options, most patients continue to relapse and die after remission, and the prognosis remains unsatisfactory. Therefore, it is necessary to explore new therapeutic approaches. Studies have found that non-coding RNA (ncRNA), especially microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), have been found to be related to the development, prognosis and drug resistance of AML. This article highlights recent findings on the association of ncRNA with AML, laying the foundation for the development of highly specific diagnostic tools and more robust treatment strategies for future AML.
出处
《临床医学进展》
2024年第4期2964-2970,共7页
Advances in Clinical Medicine
