摘要
SCF (SKP1-Cullin 1-F-box protein) E3泛素连接酶作为E3泛素连接酶中最重要的家族,负责人类机体内多种蛋白的降解。其中,F-box蛋白作为SCF E3泛素连接酶的底物受体,其功能失调在包括原发性肝癌在内的多种人类癌症中发挥着重要的作用。本文将根据国内外文献报道FBXW7在原发性肝癌发生发展中发挥的重要角色,为未来针对FBXW7及其信号通路的分子靶向药物的开发在原发性肝癌中的运用提供方向。
As the most important family of E3 ubiquitin ligases, SCF (SKP1-Cullin1-F-box protein) E3 ubiquitin ligases are responsible for the degradation of a variety of proteins in the human body. Among all the components of SCF E3 ubiquitin ligases, aberrant regulation of the F-box protein plays an important role in a variety of human cancers, including primary liver cancer. In this paper, we will report the important role of FBXW7 in the occurrence and development of primary liver cancer according to domestic and foreign literatures. It also provides a direction for the exploitation of molecular targeting drugs of FBXW7 and its signaling pathway in the application of primary liver cancer in the future.
出处
《临床医学进展》
2021年第3期1362-1366,共5页
Advances in Clinical Medicine
