摘要
小鼠口饲苦参液或将氧化苦参碱直接作用于脾细胞均不影响IgE抗体形成。氧化苦参碱明显抑制变应原诱导的肥大细胞脱颗粒作用,其抑制效应与药物浓度呈正相关。氧化苦参碱不阻断抗原与特异性抗体结合,亦不改变细胞内cAMP水平,但能降低细胞膜的流动性,稳定细胞膜。后者可能是苦参抑制肥大细胞释放组织胺治疗Ⅰ型变态反应的药理学基础。
Studies in mice, we have demonstrated that (1) Neither SFA product nor OXY has any influenceon IgE antibody response in vivo. (2) OXY i?ibited the histamine release from peritoneal mast cellsinduced by anti-DNP IgE and TNP-KLH in a dose dependent manner. Further studies have shownthat the inhibitory effects are probably neither due to the blocking. of specific binding of antigen andantibody, nor due to the changing of cellular lever of cAMP. However, when P815 cells were incuba-ted with the effective concentration of OXY, the fluidity of cellular membrane was decreased, sugges-ting that the histamine release inhibitory effects of OXY might result from the stabilizing activity ofcellular membrane and this characteristic of OXY might be the pharmacologic basis that made it asuccessful therapy of allergic diseases.
出处
《北京医科大学学报》
CSCD
1993年第2期84-86,共3页
Journal of Peking University(Health Sciences)
基金
自然科学基金
