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不动杆菌微生物学耐药研究新进展 被引量:58

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摘要 不动杆菌无处不在 ,医院环境的污染在不动杆菌爆发流行中有重要意义。不动杆菌耐药呈出现早、耐药谱广的特点 ,并易造成院内感染的爆发。其中 ,对 β -内酰胺类抗生素的耐药机制包括灭活酶的产生 ,青霉素结合蛋白的改变以及细胞膜通透性的改变。对不动杆菌院内感染可通过脉冲场凝胶电泳进行同源性检测。合理使用抗生素可以延缓不动杆菌耐药株的出现 ,治疗上目前主张使用酶抑制剂舒巴坦 /氨苄西林或某些非传统的抗生素。
出处 《国外医药(抗生素分册)》 CAS 2004年第3期134-137,共4页 World Notes on Antibiotics
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