1Schmidt A,Schwind B,Gillich M,et al.Simultaneous determination of leflunomide and its active metabolite,A771726,in human plasma by high-performance liquid chromatograpb.Biomed Chromatogr,2003,17:276
2Bartlett RR,Vrendel S,Zielinski T,et al.Leflunomide,an immunorestoring drug for the therapy of autoimmune disorders,especially rheumatoid arthritis.Transplantation Proc,1996,28:3074
3Lucien J,Dias VC,Le Gatt,et al.Blood distribution and single-dose pharmacokinetics of leflunomide.Ther Drag Monit,1995,17:454
4Davis JP,Cain GA,Pitts WJ,et al.The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase.Biochemistry,1996,35:1270
5Fairbanks LD,Bogil M,Ruekemann K,et al.Importance of ribonucleotide available to proliferating T-lymphocyte from healthy humans:disproportion expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.J BioChem,1995,270:29682
6Siemasko KF,Chong ASF,Williams JW,et al.Regulation of B cell function by the immunosuppressive agents leflunomide.Transplantation,1996,Feb 27;61(4) :635
7Fox RL,Mukhopadhyay A,Aggarwal BB.Mechanism of action of leflunomide in rheumatoid arthritis.J Rheumatol,1998(Suppl),53:20
8Morris RE,Huang X,Cao W,et al.Leflunomide (HWA 486) and its analog suppress T- and B-cell proliferation in vitro,acute rejection,ongoing rejection,and antidonor antibody synthesis in mouse,rat,and cynomolgus monkey transplant recipients as well as arterial intimal thickening after ballon catheter injury.Transplant Proc,1995,27:445
9Siemasko KF,Chong AS,Williams JW,et al.Regulation of B cell function by the immunosuppressive agent leflunomide.Transplantation,1996,61:635
10Williamson RA,Yea CM,Robson PA,et al.Dihydroorotate dehydrogenase is a high affinity binding protein for A771726 and mediator of a range of biological effects of the immunomodulatory compound.J Biol Chem,1995,270:22467
