摘要
目的 通过检测龈沟液(GCF)中Ⅱ型胶厚酶(COL-Ⅱ)的水平,探讨COL-Ⅱ作为早期牙周病诊断指标的可行性。方法 用滤纸条的袋口取样法取180例患者的GCF样本.采用ELISA法测定COL-Ⅱ水平。结果 COL-Ⅱ水平在牙周炎组、牙龈炎组、牙周健康组之间均有显著差异(P<0.001),酶水平与龈沟液体积、探诊深度、附着丧失、龈沟出血指数呈正相关关系。结论 龈沟液中的COL-Ⅱ水平对早期牙周病的辅助诊断有较大参考价值。
(Abstract] Objective To determine the possibility of Ⅱ type collagenase (COL- Ⅱ) in gingival crevicular fluid (GCF) as the diagnostic parameter for early periodontal disease through determining their levels in GCF. Methods GCF was sampled with filter strips by entrance-pocket method from one hundred and eighty patients. The levels of COL- Ⅱ were determined by ELISA. Results The levels of COL- Ⅱ were significantly different among periodontitis, gingivitis and healthy group (P<0.001) .The GCF volume, probing depth, attachment loss and sulcus bleeding index were positively related with the levels of enzyme. Conclusions COL- Ⅱ could be helpful in early diagnosis for periodontal disease.
出处
《福建医药杂志》
CAS
2004年第2期18-19,共2页
Fujian Medical Journal
关键词
龈沟液
胶原酶
检测
牙周病
诊断
Gingival crevicular fluid
Periodontal disease
Collagenase
