摘要
由对硝基甲苯为原料合成对氨基苯甲酸乙酯(即苯佐卡因)时,在酯化反应过程中,一般都是用浓硫酸作为催化剂,苯佐卡因的收率比较低。本文研究常用路易斯酸作为催化剂,发现苯佐卡因的收率可提高到67%。
Using p-Nitrotoluene to synthesize ethyl p-aminobengoate needs three steps, i.e. oxidizing,reducing and esterifying. During esterifying, we generally use concerntrated sulphuric acid as catalyst and the yield is low. The author used lewis acid as the catalyst and found the yield was raised as high as 67%.
出处
《浙江工业大学学报》
CAS
2004年第2期143-145,共3页
Journal of Zhejiang University of Technology
