摘要
观察苦豆碱(Aloperine)对前列腺素环加氧酶活性的影响。通过放免测定酶促反应的生成物PGE_2和PGF_(2a)来评价环加氧酶的活力。小鼠腹腔注射苦豆碱(50mg·kg^(-1)·d^(-1)),连续7d,观察肺、肾等组织匀浆对外源性底物花生四稀酸的反应,结果表明给药组的PGE_2和PGF_(2a)合成量明显高于对照组,提示苦豆碱能够明显促进前列腺素环加氧酶的活力。
Experimental studies were made on enhancing effect of aloperine on PG-cyclooxyge-nase activity. Radioimmunoassay for determination of PGE2 and PGF2α contents was employed to evaluate PG-cyclooxygenase activity. Mice were given aloperine (50mg · kg · d-1) ip for 7d and the effects of lung and kidney homogenates on extrogenous arachidonic acid were studied. The results suggest that biosynthesis of PGE2, PGF2α be obviously increased in the experimental than that of control, suggesting of aloperine showing enhancing effect on PG-cyclooxygenase activity.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第4期259-261,共3页
Chinese Pharmacological Bulletin
关键词
苦豆碱
前列腺
放射免疫测定
Aloperine
Prostaglandin Cyclooxygenase
Radioimmunoassay
Prostaglandin E_2
Prostaglandin F_(2u)
