摘要
CD44是一种跨膜受体蛋白 ,属于黏附分子家族 ,可与透明质酸等配体结合 ,介导细胞与细胞、细胞与基质之间的黏附。近年来发现CD44及其变异体在许多肿瘤细胞中异常表达 ,且与肿瘤的发生发展及患者的预后存在着一定的关系 ,因此 。
CD44 is a transmembrane receptor protein, belonging to the family of adhesion molecules, which is involved in cell-cell and cell-matrix interactions by binding with ligands such as hyaluronan. Recently a lot of researches reported that CD44 and its variant isoforms, especially CD44v6, are usually aberrantly expressed in many kinds of tumor cells, which is correlated with the invasion and metastasis of tumors and the prognosis of the patients.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2004年第3期248-251,共4页
Chinese Pharmacological Bulletin
基金
山东省卫生厅资助项目 No 2 0 0 1CA 2CAA 2
关键词
CD44
肿瘤
侵袭
转移
预后
CD44
tumors
invasion
metastasis
prognosis
