摘要
本研究采用高效液相色谱法测定头孢呋辛血浓度。对单剂量及多剂量口服头孢呋辛酯后,该药在呼吸系统感染病人体内的药代动力学特性及血药浓度变化进行测定和讨论,并根据迭加原理预测多剂量给药后的药物浓度,将预测值与实测值进行比较,结果非常接近。将测定的时间药物浓度数据经3P87药物动力学程序处理,求出头孢呋辛酯在呼吸系统感染病人体内的药代动力学参数。其消除速率常数为0.38±0.04h^(-1);消除半衰期1.85±0.22h;达峰时间2.72±0.13h;峰浓度6.13±2.07mg/l;中央室分布容积23.89±4.79(l);血清总清除率14.66±3.34l/h;滞后时间1.88±0.07h。
The concentration of cefuroxime (CXM)was measured by HPLC in this studies. Re-search on pharmacokinetic characteristics of cefuroxime axetil (CAE)in the patients with respiratory infec-tions has been carried out after single and multi-dose oral CAE,CXM level after mult-dose oral CAE hasbeen predicted based on reiterating-plus method,measured results approach predicted results after compari-son. Pharmacokinetic parameters of 10 patients with respiratory infections were as follows: The eliminationhalf-life, elimination rate constant, distribution half-life, distribution rate constant, absorption rate constant,peak time,peak level,distribution volume,serum clearance,area under curve and lag time were 1.85±0.22h,0.38±0.04/h,0.82±0.21h, 0.94±0.40/h, 2.06±0.08/h, 2.72±0.13h, 6.13±2.07mg/l, 23.89±4.79 l,14.66±3.34 l/h, 18.01±4.94mg/l,h and 1.88±0.07h,respectively.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1992年第4期209-214,共6页
The Chinese Journal of Clinical Pharmacology
关键词
头孢呋辛酯
药代动力学
分析
cefuroxime axetil 1pharmacokinetics 1 reiterating--plus method
HPLC.
