1Parente L;Perretti M.Advances in the pathophysiology of consti tutive and inducible cyclooxygenases: two enzymes in the spotlight[J],2003(2).
2DuBois RN;Abramson SB;Crofford L.Cyclooxygenase in biology and disease[J],1998.
3Tanaka A;Araki H;Komoike Y.Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs,2000.
4Wallace JL;McKnight W;Reuter BK.NSAID-induced gas tric damage in rats:requirement for inhibition of both cyclooxygenase 1 and 2[J],2000(3).
5Abdel-salam OM;El Shenawy S;El Batran S.The effect of etodolac on bile salt and histamine-mediated gastric mucosal injuryin the rat,2001.
1Guth PH,Aures D,Paulsen G.Topical aspirin plus HCl gastric lesions in the rat.Cytoprotective effect of prostaglandin,cimetidine and probanthine.Gastroenterology,1979,76:88-93.
2Fosslien E.Adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal system.Ann Clin Lab Sci,1998,28:67-81.
3Goldstein JL,Silverstein FE,Agrawal NM,et al.Reduced risk of upper gastrointestinal ulcer complications with celecoxib,a novel COX-2 inhibitor.Am J Gastroenterol,2000,95:1681-1690.
4Singh G,Rosen-Ramey D.NSAID induced gastrointestinal complications: the ARAMIS perspective-1997.Arthritis,Rheumatism,and Aging Medical Information System.J Rheumatol Suppl,1998,516-518.
5Laudanno OM,Cesolari JA,Esnarriaga J,et al.Gastrointestinal damage induced by celecoxib and rofecoxib in rats.Acta Gastroenterol Latinoam,2000,30:27-33.
6Mizuno H,Sakamoto C,Matsuda K,et al.Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice.Gastroenterology,1997,112:387-397.
7Shigeta J,Takahashi S,Okabe S.Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.J Pharmacol Exp Ther,1998,286:1383-1390.
8Wiliams CS,Dubois RN. Prostaglandin endoperoxide synthase: Why two isoforms? Am J Physiol, 1996,270(3 Pt1):G393 - G400
9Dixon MF,Genta RM,Yardlry JH,et al. Classification and grading of gastritis. The updated sydney system. international wordshop on the Histopathology of Gastritis, Houston, 1994, Am J Suig Pathol, 1996,20( 10 ): 1161 - 1181
10Salim AS. The relationship between Helicobacter pylori and oxygen - derived free radicals in the mechanism of duodenal ulceration. Inter Med, 1993,32(5) :359 - 364