摘要
目的 探讨放射性粒子组织间植入治疗对患者末稍血像、肝功能、肾功能、T细胞亚群和NK细胞活性的影响。方法 病理证实为恶性肿瘤且不能手术根治的 2 5例患者 ,超声引导下或术中植入1 2 5I粒子。比较治疗前和治疗后 3个月内多个时间点末梢血像、肝功能、肾功能及T细胞亚群、NK细胞活性的变化。 结果 治疗前白细胞、血红蛋白、血小板为 (6 3±2 2 )× 10 9 L、(12 2 7± 17 3)g L、(2 19 9± 117 5 )× 10 9 L ,治疗后 1月及 3月分别为 (6 4± 1 8)× 10 9、(114 5± 30 9)g L、(191 5±5 9 6 )× 10 9 L和 (6 1± 1 2 )× 10 9、(116 3± 16 0 )g L、(191 7± 10 8 2 )× 10 9 L ,无显著性差异 (F分别为 1 893、0 6 16、0 5 96 ,P分别为 0 0 72、0 779和 0 76 2 )。ALT、AST、BUN、Cr、CK及CK -MB检测在各时间点亦无显著差异 (F值分别为 1 86 1、0 5 5 1、1 74 0、1 934,0 4 12 ,0 0 5 2 ,P值分别为 0 118、0 737、0 14 2、0 10 5、0 837、0 998)。胰腺癌患者总胆红素、直接胆红素在治疗后 1月有明显下降。粒子治疗对患者T淋巴细胞亚群 (CD3、CD4 和CD8)及NK细胞活性没有明显影响 (F值分别分 0 2 87、0 5 2 0、0 4 97、1 10 1,P值分别为 0 75 2、0 5 98、0 6 12、0
Objective To explore the effects of interstitial brachytherapy with permanent seed implants on peripheral blood cells, liver functions, renal functions, T cells subgroups and the activity of natural killer cells (NK). Methods Ultrsound-guided or intraoperative implants of radioactive seed 125I were used in 25 patients with pathologically diagnosed and ineradicable malignant tumors. Clinical data of peripheral blood cells, liver functions, renal functions, T cells subgroups and the activity of NK cells prior and after the treatment were compared. Results The white blood cells, hemoglobin and platelet prior the treatment were (6 3±2 2)×10 9/L, (122 7±17 3) g/L and (219 9±117 5)×10 9/L, respectively, while at the 1st and 3rd months after the treatment, these were (6 4±1 8)×10 9/L, (114 5±30 9)g/L, (191 5×59 6)×10 9/L, respectively and (6 1±1 2)×10 9/L, (116 3±16 0) g/L, (191 7±108 2)×10 9/L, respectively, without statistically significant differences ( F =1 893, 0 616, 0 596; P =0 072, 0 779, 0 762). In addition, no significant differences were found in values of ALT, AST, BUN, Cr, CK and CK-MB at different times ( F =1 861, 0 551, 1 740, 1 934, 0 412, 0 052; P =0 118, 0 737, 0 142, 0 105, 0 837, 0 998). The values of TB and DB in patients with pancreatic carcinoma obviously decreased within 1 month after the treatment. Interstitial brachytherapy had little effects on T-cell immunity (CD3, CD4 and CD8) and the activity of NK cells ( F =0 287, 0 520, 0 497, 1 101; P =0 752, 0 598, 0 612, 0 342). Conclusions Interstitial brachytherapy with permanent seed implants has no effects on vital organs and immunologic functions, being a safe and minimally invasive technique for cancer.
出处
《中国微创外科杂志》
CSCD
2003年第3期219-221,共3页
Chinese Journal of Minimally Invasive Surgery
关键词
125I粒子
组织间植入
毒性
Radioactive seed 125I
Interstitial brachytherapy
Toxicity
