摘要
目的 :研究多发性骨髓瘤 (MM )患者血浆中脑源性神经营养因子 (BDNF)、血管内皮细胞生长因子(VEGF)的表达情况及与相应临床检测指标的关系 ,初步探讨BDNF在多发性骨髓瘤的发生与发展中的潜在作用。方法 :用酶联免疫吸附试验 (ELISA)测定MM患者与健康体检者血浆BDNF、VEGF的浓度 ,同时观察MM患者血常规、肾功能、电解质、影像学等指标。结果 :患者血浆BDNF浓度为 (4 .2 2± 0 .6 4 ) μg/L ,与健康体检者(2 .0 3± 0 .38) μg/L比较 ,差异有统计学意义 (P <0 .0 5 ) ;患者血浆VEGF浓度为 (79.35± 13.2 5 )ng/L ,与健康体检者 (34.4 1± 1.78)ng/L比较 ,差异有统计学意义 (P <0 .0 1)。BDNF与VEGF水平间存在着相关性 (r =0 .4 30 ,P =0 .0 2 5 )。结论 :MM患者血浆BDNF和VEGF显著增高 。
Objective:To investigate the expression of brain derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in multiple myeloma patients and analyze the correlation of two cytokine levels to clinical parameters.Method:The plasma concentration of BDNF and VEGF in MM patients and control group were determined by ELISA . The results of patients' clinical examinations were recorded at the same time. Result: The concentration of BDNF were ( 4.22± 0.64)μg/L and ( 2.03± 0.38)μg/L in MM group and control group, respectively(P< 0.05). There was also a significant difference between VEGF levels of two groups [ ( 79.35± 13.25) ng/L∶ ( 34.41± 1.78) ng/L, P< 0.01].The levels of BDNF and VEGF correlated significantly (r= 0.430,P= 0.025 ).Conclusion: The concentrations of BDNF and VEGF in MM patients' peripheral blood were at high level. BDNF is likely to be a novel angiogenic protein.
出处
《临床血液学杂志》
CAS
2004年第2期82-83,86,共3页
Journal of Clinical Hematology
