摘要
在机体内 ,血细胞间或血细胞与血管内皮间的相互作用主要由粘附分子介导来实现。粘附分子的作用广泛 ,涉及细胞的粘附、迁移、分化和信号传导等 ,它们维持血细胞的正常结构并协助血细胞发挥其各种生理功能。但是 ,粘附分子功能的异常或缺陷则会影响正常生理功能导致疾病发生。本文介绍了多种粘附分子 ,包括整合蛋白、选择蛋白、免疫球蛋白超家族等 ,并探讨了一些与粘附分子相关的病理生理过程 ,如炎症、止血、动脉粥样硬化、血栓形成和干细胞归巢等。因此了解血细胞粘附分子的结构与功能有助于人们深入认识疾病的发病机理 ,寻找疾病诊断和治疗的新的靶点。
The interactions between blood cells and blood cells or blood cells and endothelium of blood vessel are mainly mediated by adhesion molecules. The role of adhesion molecules is diverse in vivo , which involved in adhesion, migration, differentiation and signal transduction of blood cells. The function of adhesion molecules is necessary to maintain the normal structure and fulfill many physiological processes of these cells. Therefore, the abnormal or deficiency of their expression and function will disrupts normal physiological processes and results in clinical disease. In this paper, several generic classes of adhesion molecules, including the integrins, the selectins, the immunoglobulin superfamily and others are introduced, and a lot of related physiopathological status, such as inflammation, hemostasis, arteriosclerosis, thrombosis and stem cell homing are discussed. The studies on the adhesion molecules of blood cells will contribute not only to understand the pathogenesis of some disorders, but also to search new targets in diagnosis and treatment of these diseases.
出处
《中国实验血液学杂志》
CAS
CSCD
2004年第1期1-5,共5页
Journal of Experimental Hematology
