摘要
目的:研究替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移癌的疗效及对白细胞介素(IL)-4、IL-10、肿瘤坏死因子(TNF)-α水平的影响。方法:选取2014年3月-2015年5月于我院行胃癌根治术后发现腹腔淋巴结转移癌患者84例,按随机数字表法分为观察组与对照组,各42例。对照组给予放疗(46~53 Gy)治疗,观察组在对照组基础上给予替吉奥(40 mg,bid,po)序贯化疗治疗。比较两组临床近期疗效,治疗前后IL-4、IL-10、TNF-α水平变化情况,不良反应发生情况以及生活质量。结果:观察组治疗总有效率为76.19%(32/42),显著高于对照组的54.76%(23/42),差异有统计学意义(P<0.05)。治疗后,观察组IL-4、IL-10水平显著低于对照组,TNF-α水平显著高于对照组,差异有统计学意义(P<0.05)。观察组肾功能损害、消化道反应以及血小板减少发生率分别为2.38%(1/42),4.76%(2/42),2.38%(1/42),均显著低于对照组的16.67%(7/42),19.05%(8/42),13.29%(6/42),差异均有统计学意义(P<0.05)。观察组各项生活质量评分均显著高于对照组,差异有统计学意义(P<0.05)。结论:替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移癌疗效显著,降低不良反应发生率,同时提高生活质量。
Objective:To study the efficacy of tegafur gimeracil oteracil potassium combined with radiation sequential chemotherapy in the treatment of abdominal lymph node metastatic cancer after radical resection of gastric cancer and effect on the levels of interleukin(IL)-4, IL-10 and tumor necrosis factor(TNF)-α. Methods:84 patients with lymph node metastatic cancer after radical resection of gastric cancer in our hospital from March 2014 to May 2015 were selected and divided into observation group and control group according to the random number table method, 42 cases in each group. The patients in the control group were treated by radiotherapy(46~53 Gy), and the patients in the observation group were given tegafur gimeracil oteracil potassium sequential chemotherapy(40 mg, bid, po) on the basis of the control group. The clinical short-term efficacy, the changes of IL-4, IL-10, and TNF-α levels before and after treatment, the incidence of adverse reactions and the quality of life were compared between the two groups. Results:The total effective rate of the observation group was 76.19%(32/42), which was significantly higher than 54.76%(23/42) of the control group, and the difference was statistically significant(P<0.05). After treatment, the levels of IL-4, IL-10 in the observation group were significantly lower than those in the control group, while the level of TNF-α in the observation group was significantly higher than that in the control group(P<0.05). The incidences of renal impairment, digestive tract reaction and thrombocytopenia in the observation group were 2.38%(1/42), 4.76%(2/42) and 2.38%(1/42), respectively, which were significantly lower than 16.67%(7/42), 19.05%(8/42) and 13.29%(6/42) in the control group(P<0.05). The scores of the quality of life in the observation group were significantly higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion:Tegafur gimeracil oteracil potassium combined with radiation sequential chemotherapy has significant therapeutic effect on abdominal lymph node metastatic cancer after radical resection of gastric cancer, and reduces the incidence of adverse reactions and improves the quality of life.
出处
《中国执业药师》
CAS
2018年第6期18-21,共4页
China Licensed Pharmacist
关键词
转移癌
胃癌根治术
替吉奥
化疗
放疗
Metastatic Cancer
Radical Resection
Tegafur Gimeracil Oteracil Potassium
Chemotherapy
Radiotherapy
