摘要
目的 :观察培美曲塞(PEM)联合顺铂方案对乳腺癌无症状脑转移的疗效及不良反应。方法 :选取入住我院乳腺癌无症状脑转移患者35例,给予培美曲塞联合顺铂治疗:培美曲塞500 mg/m2 d1,顺铂25 mg/m2 d1~d3,21 d为1个周期。两个周期后进行疗效评价,并统计不良反应发生情况。结果 :颅内转移灶的疗效:部分缓解8例(22.9%),疾病稳定16例(45.7%),疾病进展11例(31.4%),有效率为22.9%,疾病控制率为68.6%,全身病灶的总体疗效:部分缓解9例(25.7%),疾病稳定14例(40.0%),疾病进展12例(34.3%),有效率为25.7%,疾病控制率为65.7%。主要不良反应为骨髓抑制、胃肠道反应等。结论 :培美曲塞联合顺铂治疗乳腺癌无症状脑转移疗效较好,不良反应可耐受,值得临床进一步研究应用。
Objective:To observe the effects and side-effects of pemetrexed(PEM) and cisplatin in the treatment of breast cancer with asymptomatic brain metastasis.Methods:35 patients of breast cancer with asymptomatic brain metastasis in our hospital were all received pemetrexed plus cisplatin treatment for 21 days per cycle,and each cycle followed by intervention using PEM 500 mg/m^2 on the first day and cisplatin 25 mg/m^2 from day 1 to day 3,for two cycles.The efficacy and adverse reaction after two cycles were assessed.Results:Local cerebral response assessment showed that 8 patients(22.9%) got a partial response(PR),16(45.7%) had a stable disease(SD) and 11(31.4%) had a progressive disease(PD).The objective response rate was 22.9%,and the disease control rate was 68.6%.General lesion assessment presented that 9(25.7%),14(40.0%) and 12(34.3%) patients got PR,SD and PD,respectively.The objective response rate was 25.7%,and the disease control rate was 65.7%.The main adverse reactions were bone marrow suppression,gastrointestinal reaction and so on.Conclusion:The treatment of the patients with asymptomatic brain metastasis in breast cancer after pemetrexed(PEM) and cisplatin is efficacious,with minor adverse effects,providing broad prospects in clinic application.
出处
《中国执业药师》
CAS
2017年第12期7-9,共3页
China Licensed Pharmacist
关键词
培美曲塞
顺铂
脑转移
乳腺癌
Pemetrexed
Cisplatin
Brain Metastasis
Breast Cancer
