摘要
目的 :探讨奥美拉唑联合阿莫西林、甲硝唑在幽门螺杆菌感染免疫性血小板减少症治疗中的应用价值。方法 :选取我院2012年1月-2015年12月收治的幽门螺杆菌感染相关免疫性血小板减少症患者100例作为研究对象。按随机数字表法分为观察组与对照组,各50例。对照组采用常规综合疗法治疗,观察组则在常规疗法基础上联合奥美拉唑(0.6~0.8 kg/d)+阿莫西林[50 mg/(kg·d)]+甲硝唑[20 mg/(kg·d)]进行治疗,比较两组患者治疗效果及复发情况。结果 :观察组治疗后总有效率明显高于对照组(P<0.05);两组治疗前血小板数量比较无统计学差异(P>0.05),治疗后观察组血小板数量明显高于对照组(P<0.05);治疗后1年随访结果显示观察组总复发率明显低于对照组(P<0.05)。结论 :在常规综合治疗基础上联合应用奥美拉唑、阿莫西林、甲硝唑进行幽门螺杆菌根除治疗,可有效提升幽门螺杆菌感染免疫性血小板减少症患者的临床治疗效果,具有一定的临床价值。
Objective:To explore the application value of omeprazole combined with amoxicillin and metronidazole in the treatment of immune thrombocytopenia with helicobacter pylori infection. Methods:100 cases of patients with immune thrombocytopenia with helicobacter pylori infection treated in our hospital from January 2012 to December 2015 were selected as the research object. The patients were divided into observation group and control group according to the random number table method, 50 cases in each group. The control group was received routine comprehensive treatment, the observation group was treated with omeprazole(0.6~0.8 kg/d) combined with amoxicillin [50 mg/(kg·d)] and metronidazole [20 mg/(kg·d)] on the basis of routine treatment. Therapeutic effect and recurrence was compared between the two groups. Results:After treatment, the total efficiency of the observation group was significantly higher than that of the control group(P<0.05), there was no significant difference in platelet count between the two groups before treatment(P>0.05). After treatment, platelet count in observation group was significantly higher than that in the control group(P<0.05). The 1 year follow-up results showed that the total recurrence rate of the observation group was significantly lower than that of the control group(P<0.05). Conclusion:The combined application of omeprazole, amoxicillin and metronidazole based on routine treatment in the treatment of helicobacter pylori eradication, can effectively improve the clinical treatment effect of patients with immune thrombocytopenia with helicobacter pylori infection, and has certain clinical value.
出处
《中国执业药师》
CAS
2017年第10期51-53,共3页
China Licensed Pharmacist
