摘要
目的探讨不良孕产史与染色体异常之间的关系,并分析异常染色体的检出率和类型,为优生优育提供临床参考依据。方法取患者的外周血进行培养、制片及G显带技术进行染色体核型分析。结果 1292例不良孕产史患者中,染色体异常检出307例,检出率为23.76%(307/1292)。307例染色体异常患者中,习惯性流产、胚胎停育183例(59.61%,183/307);死胎、死产31例(10.10%,31/307);畸胎史18例(5.86%,18/307);产先天性疾病患儿13例(4.23%,13/307);胎儿染色体异常62例(20.20%,62/307)。结论染色体异常是导致不良孕产史的重要遗传因素,染色体检查可以对不良孕产史患者进行优生优育指导。
Objective:To explore the relationship between adverse pregnancy history and chromosomal abnormalities,analyze the detection rates and types of chromosomal abnormalities,provide the clinical reference basis for the eugenics.Methods:Cultivate lymphocyte in peripheral blood in nutritive medium,analyze the karyotype using G banding.Results:Through the karyotype analysis of 1292 cases,found that chromosome abnormality 307,the detection rate was 23.76%(307/1292).Among 307 cases with chromosomal abnormalities,183 cases were found with habitual aborition or embryo damage history,accounting for 59.61%(183/307).31 cases were found with stillbirth,accounting for 10.10%(31/307).18 cases were found with fetal deformities history,accounting for 5.86%(18/307).13 cases were found with history of children with congenital diseases,accounting for 4.23%(13/307).62 cases were found with history of fetal chromosomal abnormalities,accounting for20.20%(62/307).Conclusion:Chromosome abnormality is an important genetic factor that leads to poor pregnancy and birth history.
作者
杨文霞
覃磊
高瑞宏
王德堂
陈必良
张建芳
YANG Wen-xia;TAN Lei;GAO Rui-hong;WANG De-tang;CHEN Bi-liang;ZHANG Jian-fang(The First Affiliated Hospital of Air Force Medical University,Xian 710032)
出处
《中国优生与遗传杂志》
2019年第9期1070-1071,共2页
Chinese Journal of Birth Health & Heredity
关键词
不良孕产史
染色体异常
Adverse pregnancy history
Chromosomal abnormality
