摘要
目的:探讨前列消癥汤治疗ⅢA型(湿热挟瘀型)慢性前列腺炎的临床效果。方法:选择符合纳入标准的136例ⅢA型慢性前列腺炎(湿热挟瘀型)患者按照就诊顺序,随机分成两组,每组68例。对照组给予基础治疗,观察组在对照组基础上口服前列消癥汤,观察两组患者治疗前后NIH-CPSI评分(疼痛、排尿、生活质量)、尿流率、WBC计数、炎性因子的变化情况及临床疗效。结果:治疗后观察组总有效率为91. 18%(62/68),对照组总有效率70. 59%(48/68),差异有统计学意义(P <0. 05);与治疗前比较,治疗后两组患者最大尿流率、平均尿流率相对于治疗前均有显著改善(P <0. 05),观察组增加更明显(P <0. 05);治疗后两组NIH-CPSI评分系统中疼痛、排尿、生活质量、总评分均显著低于治疗前(P <0. 05);与对照组比较,观察组治疗后NIH-CPSI评分系统各项评分显著低于对照组(P <0. 05);治疗后两组前列腺液(EPS)中白细胞(WBC)计数较治疗前显著减少(P <0. 05),观察组改善更明显(P <0. 05);治疗后两组EPS中白介素-6(IL-6)、白介素-8(IL-8)以及肿瘤坏死因子α(TNF-α)水平均显著低于治疗前,差异有统计学意义(P <0. 05);治疗后,观察组EPS各项炎性因子水平均显著低于对照组(P <0. 01)。结论:前列消癥汤能有效改善ⅢA型(湿热挟瘀型)慢性前列腺炎临床症状,减轻前列腺组织炎症损伤,提高患者生活质量。
Objective: To explore the clinical efficacy of Qianlie Xiaozheng Decoction in the treatment of chronic prostatitis Ⅲ A(pattern of damp-heat and stasis). Methods: 136 cases of chronic prostatitis Ⅲ A were randomly divided into the control group(n = 68) and the observation group(n = 68) according to the order of seeing doctors. The control group was given basic treatment;on which basis,the observation group was treated with Qianlie Xiaozheng Decoction. NIH-CPSI scores(pain,urination,urine flow rate,quality of life),urine flow rate,the count of WBC,inflammatory factors,and clinical curative effect were observed before and after the treatment in the two groups. Results: After the treatment,the total effective rate of the observation group was 91. 18%(62/68),which was significantly higher than 70. 59%(48/68) of the control group(P < 0. 05). The maximum urine flow rate and the average urine flow rate were significantly improved in the two groups after the treatment(P < 0. 05);of which the observation group improved more significantly(P < 0. 05). NIH-CPSI scores in pain,urination and quality of life,as well as the total scores were significantly lowered in the two groups after the treatment(P < 0. 05);of which the observation was significantly lower than the control group(P < 0. 05). WBC counts in the expressed prostatic secretions(EPS) was significantly lower after the treatment in the two groups(P < 0. 05);of which the observation group improved more significantly(P < 0. 05). The levels of IL-6,IL-8,and TNF-α in EPS were significantly lower after the treatment in the two groups(P < 0. 05);of which the observation group was significantly lower than the control group(P < 0. 01). Conclusion: Qianlie Xiaozheng Decoction can effectively improve the clinical symptoms of chronic prostatitis ⅢA(pattern of damp-heat and stasis),it can reduce the inflammation of prostate tissue and improve the life quality of the patients.
作者
杨帅平
杨俊伟
YANG Shuaiping;YANG Junwei(The Seventh People's Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《中医药信息》
2019年第2期31-35,共5页
Information on Traditional Chinese Medicine
关键词
前列消癥汤
ⅢA型慢性前列腺炎
湿热挟瘀型
生活质量
Qianlie Xiaozheng Decoction
Chronic prostatitis ⅢA
Pattern of damp-heat and stasis
Quality of life
作者简介
杨帅平(1979-),女,主治医师,主要研究方向:肾移植术后免疫抑制剂的合理应用。
