摘要
目的系统评价艾尔巴韦/格拉瑞韦(EBR/GZR)韦治疗慢性丙型病毒性肝炎(CHC)的经济学。方法计算机检索PubMed、Embase、中国期刊全文数据库、中文期刊全文数据库和万方数据知识服务平台等数据库,检索时限为2014年1月1日至2019年4月22日,根据纳入以及排标标准筛选文献,并使用卫生经济研究质量评估量表(QHES)评价纳入文献的质量,对研究结果进行系统性评价。结果最终纳入8篇文献,7篇英文文献,1篇中文文献。基于中国人群的药物经济学研究结果表明,与聚乙二醇干扰素联合利巴韦林(PR)、达拉他韦联合阿舒瑞韦(DCV+ASV)方案比较,EBR/GZR治疗基因1 b型患者具有经济学优势。基于国外人群的药物经学研究结果显示,与PR、DCV+ASV、奥比帕利联合达塞布韦(3D)联合或不联合利巴韦林(RBV)、索磷布韦联合RBV、索磷布韦联合PR、来迪派韦/索磷布韦和索磷布韦/维帕他韦方案比较,EBR/GZR治疗HCV基因1(1a,1b)型,以及合并慢性肾脏病(chronic kidney disease, CKD)患者,均具有经济学优势。结论现有药物经济学研究显示,对于基因1型CHC患者,EBR/GZR的经济学更高。
Objective To conduct a systematic review of the economics of Elbasvir/Grazoprevir in the treatment of chronic hepatitis C.Methods The computer retrieves databases such as PubMed,Embase,Chinese Journal Full-text Database,Chinese Journal Full-text Database and Wanfang Data Knowledge Service Platform.The search time is from January 1,2014 to April 22,2019.All literatures were selected according to the inclusion and exclusion criteria,and the Quality of Health Economic Studies(QHES)was applied to gauge their quality.And a systematic review of results was conducted.Results A total of 8 studies were included,7 for English manuscripts and 1 for Chinese manuscripts.Results from domestic pharmacoeconomic evaluation indicate that,compared with PR and Daclatasvir+Asunaprevir,Elbasvir/Grazoprevir has economic advantages in the treatment of HCV genotype 1b patients.The results of economic evaluation conducted in other countries show that compare with PR,Daclatasvir+Asunaprevir,3D or 3D+RBV,Sofosbuvir+RBV,Sofosbuvir+PR,Ledipasvir/Sofosbuvir and Sofosbuvir/Velpatasvir regimens,Elbasvir/Grazoprevir has economic advantages in the treatment of HCV genotype 1(1a,1b)and patients with CKD.Conclusion Existing pharmacoeconomic studies have shown that EBR/GZR has higher economics for patients with genotype 1 CHC.
作者
肖敦明
宣建伟
XIAO Dun-Ming;XUAN Jian-Wei(Shanghai Centennial Scientific Co,Ltd,Shanghai 200030,China;Sun Yat-Sen University,Guangzhou 510006,China)
出处
《中国药物经济学》
2019年第9期24-30,41,共8页
China Journal of Pharmaceutical Economics
作者简介
通信作者:宣建伟,E-mail:jwx02467@gmail.com
