摘要
目的:探讨ST2在非小细胞肺癌组织中的表达及临床意义。方法:2014年1月～2015年10月期间在本院就诊经病理组织学、细胞学检查确诊为非小细胞肺癌的45例患者,选择癌旁正常肺组织标本(距离癌组织至少10 cm)作为对照(正常肺组织组)。HE染色检测组织中免疫细胞,RT-PCR检测NSCLC及癌旁正常肺组织标本中ST2、IL-4、IFN-γ的表达。结果:(1)NSCLC患者肺癌组织中ST2表达量明显高于癌旁正常肺组织(P<0. 05);(2)与癌旁正常肺组织相比,NSCLC患者肺癌组织标本中IL-4/IFN-γ比值增大,有统计学意义。结论:非小细胞肺癌患者肺癌组织高表达ST2,ST2介导的Th1/Th2细胞因子漂移可能参与了肺癌过程。
Objective: To analyze the clinical significance of ST2 in patients with non-small cell lung cancer. Methods: HE and IHC were applied to investigate the expressions of ST2 and RT-PCR was used to detect the concentrations of ST2,IL-4 and IFN-γ in non-small cell lung cancer tissue,tissues ranging cancer at least 10 cm as the contrast. Results:(1)The levels of ST2 in NSCLC patients were significantly higher than those in benign lung tissues paracancer( P<0. 05).(2)Contrasted with benign lung tissues paracancer,the ratio of the concentration of IL-4 versus IFN-γ was bigger in the tumor tissues. Conclusion: ST2 expressions were significant in tumor tissues,accompanying with skewing Th1/Th2. The disequilibrium of Th1/Th2 probably mediated by ST2 may exist in the development of NSCLC.
作者
凌夏君
许姣
李献文
周燕娟
庄志方
LING Xia-Jun;XU Jiao;LI Xian-Wen;ZHOU Yan-Juan;ZHUANG Zhi-Fang(Department of Respiratory Medicine,Changzhou Wujin People's Hospital,Changzhou 213017,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第6期726-728,734,共4页
Chinese Journal of Immunology
基金
江苏大学临床科技发展基金(JLY20140040
JLY20140044)
作者简介
凌夏君,男,硕士,主治医师,主要从事肺部疾病的相关研究,E-mail:1391401467@qq.com;通讯作者及指导教师:许姣,女,硕士,主治医师,主要从事肺部疾病的相关研究,E-mail:xujiaoweiyi@163.com。
