期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

结肠腺癌患者术后组织中NQO-1、Cath-D和Ki-67的表达及意义 被引量：2

在线阅读 下载PDF
导出
摘要 目的应用免疫组化方法检测结肠腺癌中NADPH:醌氧化还原酶(NQO)-1、组织蛋白酶(Cath)-D和Ki-67增殖指数(Ki-67)的表达,分析其关系及临床意义。方法经病理确诊的124例结肠腺癌术后组织及临床资料作为观察组,80例上皮内瘤变的结肠黏膜组织作为对照组,80例正常结肠黏膜组织作为正常对照组,应用免疫组化方法检测三组中NQO-1、Cath-D和Ki-67的表达。结果三组中NQO-1、Cath-D和Ki-67表达的阳性率差别有统计学意义,观察组中NQO-1、Cath-D和Ki-67的表达与肿瘤的分化程度、浸润深度、TNM分期、脉管浸润、淋巴结转移密切相关。相关性分析显示NQO-1和Ki-67、Cath-D和Ki-67的表达均具有正相关性。结论结肠腺癌术后组织中NQO-1、Cath-D和Ki-67均高表达,NQO-1和Cath-D均与Ki-67的表达具有协同作用,对促进肿瘤的发生、进展和增殖有一定作用。
作者 屈中玉
机构地区 南阳市中心医院肿瘤内科一病区
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第9期2435-2437,共3页 Chinese Journal of Gerontology
关键词 结肠腺癌 NQO-1 CATH-D KI-67 免疫组化
分类号 R735.35 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Awadallah N.S.,Shah R.J.,Chen Y.K.,Dehn D.,Ross D.,Russell Nash S.,Shroyer K.R.,Bentz J.S.NQO1 expression in pancreatic cancer and its potential use as a biomarker. Applied Immunohistochemistry and Molecular Morphology . 2008
  • 2Chiu Mei-Miao,Ko Ying-Ju,Tsou Ann-Ping,Chau Gar-Yang,Chau Yat-Pang.Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. Histology and Histopathology . 2009
  • 3Szajda Slawomir Dariusz,Snarska Jadwiga,Jankowska Anna,Roszkowska-Jakimiec Wieslawa,Puchalski Zbigniew,Zwierz Krzysztof.Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients. Hepato Gastroenterology . 2008
  • 4Waszkiewicz Napoleon,Zalewska-Szajda Beata,Szajda S?awomir D,K?pka Alina,Waszkiewicz Magdalena,Roszkowska-Jakimiec Wies?awa,Wojewódzka-?ele?niakowicz Marzena,Milewska Anna J,Dadan Jacek,Szulc Agata,Zwierz Krzysztof,Ladny Jerzy R.Lysosomal exoglycosidases and cathepsin D in colon adenocarcinoma. Polskie Archiwum Medycyny Wewn?trznej . 2012
  • 5Dian D,Heublein S,Wiest I,et al.Significance of the tumor protease cathepsin D for the biology of breast cancer. Histology and Histopathology . 2014
  • 6Zhu C L,Huang Q,Liu C H,et al.NAD (P)H:quinone oxidoreductase 1 (NQO1)C609T gene polymorphism association with digestive tract cancer:a meta-analysis. Asian Pacific Journal of Cancer Prevention . 2013
  • 7Yongbing Wang,Genfu Zhang,Yunbao Luo.Association between NQO1 C609T polymorphism and colorectal cancer risk[J]. Tumor Biology . 2013 (6)
  • 8Milan Markić,ević,Ksenija Kanjer,Vesna Mandu?,ić,Marko Buta,Zora Ne?,ković,-Konstantinović,Dragica Nikolić,-Vukosavljevi&cacute.;Cathepsin D as an indicator of clinical outcome in early breast carcinoma during the first 3 years of follow-up[J]. Biomarkers Med. . 2013 (5)
  • 9Giuseppina Nicotra,Roberta Castino,Carlo Follo,Claudia Peracchio,Guido Valente,Ciro Isidoro.The dilemma: Does tissue expression of cathepsin D reflect tumor malignancy? The question: Does the assay truly mirror cathepsin D mis-function in the tumor?[J]. Cancer Biomarkers . 2010 (1)
  • 10Jing Chen,Yuan Lin,Ru Zhang,Zhi-jie Huang,Xing-guo Pan.Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risk of Colorectal Adenoma and Colorectal Cancer in Caucasians: A Meta-analysis[J]. Archives of Medical Research . 2012 (1)

二级参考文献52

共引文献25

同被引文献25

  • 1韩杰,吕炳蓉,檀碧波,何春年,吕柏楠,赵建辉.消化道肿瘤淋巴结转移灶多药耐药性的变化及其意义[J].中华实验外科杂志,2006,23(12):1495-1496. 被引量：28
  • 2檀碧波,韩杰,吕炳蓉,吕柏楠,何春年,赵建辉,耿玮.消化道肿瘤原发灶、淋巴结转移灶中p53、P-糖蛋白的表达及意义[J].山东医药,2007,47(21):83-83. 被引量：7
  • 3Kuratomi K,Yaon H, Tsuneoka M, et al. Immunohisto-chemical expression of mina53and Ki-67proteins in humanprimary gingival squamous cell carcinoma[ J].Kurume Med,2006,53(3-4) :71 -78.
  • 4Parenti A, Leo G,Porzionato A, et al. Exprssion of survi-ving, p5 3 ,and caspase 3 in Barrett,S esophagus carcinogen-esis [J]. Hum Pathol, 2006,37(1) : 16-22.
  • 5Genies J,Li L,Schluter C, et al. Immunobiochemical andmolecular biologic characterization of the cell roliferation-as-sociated nuclear antigen that is defined by monoclonal anti-body Ki-67[J].Am Pathol, 1991,138(4) :867-873.
  • 6Lim MS, Lee HW,Im H,et al. Predictable factors forlymph node metastasis in early gastric cancer - analysis ofsingle institutional experience [ J ]. Gastrointest Surg, 2011,15(10):1783 -1788.
  • 7Melling,Kowitz,Simon,et al. High Ki67 expression is an in-dependent good prognostic marker in colorectal cancer [ J ].Clin Pathol. 2015,8(17) :202985.
  • 8Andrade NR, Oshima CT, Gomes TS,et al. Imunoexpres-sion of Ki-67 and p53 in rectal cancer tissue after treat-ment with neoadjuvant chemoradiation [ J ]. GastrointestCancer,2011,42(1) :34-39.
  • 9Padilla D,Cubo T, Villarejo P. Molecular profile of node-negative colorectal cancer of poor prognosis using immuno-histochemical determ ination of p53, Ki - 67, VEGF,andmetalloproteinase-9 [ J ] .R^ev Esp Enfem Dig, 2Q07,99 ( 7):424.
  • 10Martin, Amorim, Mota, et al. Ki-67 Expression in CRCLymph Node Metastasis Does Not Predict Survival[ J].Bi-omed Res Int,2015,9( 13) : 131685.

引证文献2

二级引证文献8

中国老年学杂志
2015年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
关于我们 | 版权声明 | 联系我们 | 帮助中心| 意见反馈
主办单位：上海市教育委员会
技术支持：重庆维普资讯有限公司
渝公网安备 50019002500403号
使用帮助 返回顶部