摘要
目的探讨根治性放疗食管癌患者选择性淋巴引流区预防照射(ENI)与累及野照射(IFI)的疗效。方法选取2011年3月至2015年3月间福建省龙岩市第二医院收治的行根治性放疗的96例食管癌患者为观察对象进行回顾性分析。其中,采用选择性淋巴引流区预防照射的48例患者纳入ENI组,采用累及野照射的48例患者纳入IFI组。比较分析两组患者放疗后临床总有效率、治疗后3年内局部控制率、生存率和放疗后不良反应发生率。结果 ENI组患者放疗后临床总有效率与IFI组患者比较,差异无统计学意义(P> 0. 05)。ENI组患者治疗3年内局部控制率和生存率与IFI组患者比较,差异无统计学意义(P> 0. 05)。ENI组患者术后并发症发生率明显高于IFI组患者,差异有统计学意义(P <0. 05)。结论给予食管癌患者根治性放疗时,累及野照射的临床总有效率、生存率和局部控制率方面与选择性淋巴引流区预防照射疗效相当,但累及野照射可降低放疗后患者的不良反应发生率,具有较高的临床价值。
Objective To explore the efficacy of elective node irradiation( ENI) and involved-field irradiation( IFI) in radical radiotherapy for esophageal cancer. Methods A total of 96 patients with esophageal cancer who received radical radiotherapy at The Second Hospital of Longyan from March 2011 to March 2015 were randomly selected for retrospective analysis. The patients were divided into ENI group and IFI group with 48 patients in each group. The clinical overall efficacy rate,3-year local control rate,survival rate and adverse reactions after radiotherapy were compared and analyzed between the two groups.Results The overall efficacy rate in the ENI was equivalent to that in the IFI group( P > 0. 05). The 3-year local control rate and survival rate in the ENI were comparable with that in the IFI group( all P >0. 05). The postoperative adverse reactions in ENI group was higher than in the IFI group( P < 0. 05).Conclusion When radiotherapy is given to patients with esophageal cancer,the clinical overall efficacy rate,survival rate and local control rate for the elective node irradiation were comparable with involved-field irradiation. However,the incidence of adverse reactions after radiotherapy can be effectively reduced if involved-field irradiation is performed. It has high clinical value.
作者
林萍
王纪煌
肖纪南
LIN ping;WANG Ji-huang;XIAO Ji-nan(Department of Radiotherapy,The Second Hospital of Longyan,Longyan 364000,China)
出处
《中国肿瘤临床与康复》
2019年第3期300-303,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
食管肿瘤
根治性放疗
选择性淋巴引流区预防照射
累及野照射
局部控制率
生存率
Esophageal neoplasms
Radical radiotherapy
Elective node irradiation
Involved-field irradiation
Local control rate
Survival rate
作者简介
林萍,女,主治医师,主要从事肿瘤放射治疗专业。
