摘要
少突胶质细胞是中枢神经系统中一群高度特化的神经胶质细胞,由少突胶质前体细胞分化形成,其主要功能是提供髓鞘,维持轴突的完整性.早期对少突胶质细胞的研究主要集中在少突胶质前体细胞的形成机制及其分化为少突胶质细胞的过程;最近的研究侧重于对少突胶质前体细胞/少突胶质细胞参与神经退行性疾病的发病过程以及神经系统损伤修复过程.文章综述了少突胶质细胞的功能和分化发育,及其在肌萎缩侧索硬化、阿尔茨海默病、亨廷顿舞蹈病和多发性硬化中的作用.
Oligodendrocytes are a group of highly specialized glial cells in the central nervous system. They are differentiated from oligodendrocyte precursor cells. Their main functions are to provide myelin and maintain the integrity of the axons. Early studies of oligodendrocyte cells mainly focused on the origin of oligodendrocyte precursor cells and the mechanism of their differentiation into oligodendrocyte. Currently, more attention about the oligodendrocyte cells are paid on the roles of oligodendrocyte precursor cells/oligodendrocyte in the pathogenesis of neurodegenerative diseases and the repair of neurological damage. This article discussed the function and differentiation of oligodendrocytes, as well as their role in amyotrophic lateral sclerosis, Alzheimer’s disease,Huntington’s disease and multiple sclerosis.
作者
张臻
陈文利
ZHANG Zhen;CHEN Wen-li(Medical School,Kunming University of Science and Technology,Kunming 650500,China;Neurology Department,The First People's Hospital of Yunnan Province,Kunming 650032,China;The Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China)
出处
《云南大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第2期404-410,共7页
Journal of Yunnan University(Natural Sciences Edition)
基金
国家自然科学基金(81660278)
云南省卫计委高层次卫生技术人才培养项目--云南省医学学科带头人(D-201624)
作者简介
张臻(1992-),男,河南人,硕士生,主要从事神经退行性疾病发病机制的研究;通信作者:陈文利(1972-),女,云南人,主任医师,博士,主要从事神经退行性疾病发病机制的研究.E-mail:drchenwl@126.com.
